Publications by authors named "Hillary P Handler"

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Validation of a comprehensive long-read sequencing platform for broad clinical genetic diagnosis.
Siddhartha Sen, Hillary P Handler, Alec Victorsen, Zach Flaten, Aidan Ellison

Front Genet· May 2025

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Increased intrinsic membrane excitability is associated with olivary hypertrophy in spinocerebellar ataxia type 1.
Logan M Morrison, Haoran Huang, Hillary P Handler, Min Fu, Deborah M Jones

Hum Mol Genet· December 2024

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Mapping SCA1 regional vulnerabilities reveals neural and skeletal muscle contributions to disease.
Lisa Duvick, W Michael Southern, Kellie A Benzow, Zoe N Burch, Hillary P Handler

JCI Insight· March 2024

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Increased intrinsic membrane excitability is associated with hypertrophic olivary degeneration in spinocerebellar ataxia type 1.
Logan M Morrison, Haoran Huang, Hillary P Handler, Min Fu, David D Bushart

bioRxiv· October 2023

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Delineating regional vulnerability in the neurodegenerative disease SCA1 using a conditional mutant ATXN1 mouse.
Lisa Duvick, W Michael Southern, Kellie Benzow, Zoe N Burch, Hillary P Handler

bioRxiv· June 2023

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BDNF is altered in a brain-region specific manner and rescues deficits in Spinocerebellar Ataxia Type 1.
Juao-Guilherme Rosa, Katherine Hamel, Alyssa Soles, Carrie Sheeler, Ella Borgenheimer, Hillary P Handler

Neurobiol Dis· March 2023

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Disruption of the ATXN1-CIC complex reveals the role of additional nuclear ATXN1 interactors in spinocerebellar ataxia type 1.
Stephanie L Coffin, Mark A Durham, Larissa Nitschke, Eder Xhako, Amanda M Brown, Hillary P Handler

Neuron· March 2023

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Disruption of the ATXN1-CIC complex reveals the role of additional nuclear ATXN1 interactors in spinocerebellar ataxia type 1.
Stephanie L Coffin, Mark A Durham, Larissa Nitschke, Eder Xhako, Amanda M Brown, Hillary P Handler

Neuron· February 2023

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Decreasing mutant ATXN1 nuclear localization improves a spectrum of SCA1-like phenotypes and brain region transcriptomic profiles.
Hillary P Handler, Lisa Duvick, Jason S Mitchell, Marija Cvetanovic, Molly Reighard

Neuron· February 2023

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Spatial and Temporal Diversity of Astrocyte Phenotypes in Spinocerebellar Ataxia Type 1 Mice.
Juao-Guilherme Rosa, Katherine Hamel, Carrie Sheeler, Ella Borgenheimer, Stephen Gilliat, Hillary P Handler

Cells· October 2022

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Altered Capicua expression drives regional Purkinje neuron vulnerability through ion channel gene dysregulation in spinocerebellar ataxia type 1.
Ravi Chopra, David D Bushart, John P Cooper, Dhananjay Yellajoshyula, Logan M Morrison, Hillary P Handler

Hum Mol Genet· November 2020

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Antisense Oligonucleotide Therapeutic Approach for Suppression of Ataxin-1 Expression: A Safety Assessment.
Brennon O'Callaghan, Bente Hofstra, Hillary P Handler, Holly B Kordasiewicz, Tracy Cole

Mol Ther Nucleic Acids· September 2020

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Antisense oligonucleotide-mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles.
Jillian Friedrich, Holly B Kordasiewicz, Brennon O'Callaghan, Hillary P Handler, Carmen Wagener

JCI Insight· November 2018

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