Publications by authors named "Hiroyuki Motoshima"

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Hematopoietic dipeptidyl peptidase-4 deficiency promotes M2 macrophage polarization and attenuates atherosclerosis.
Yuqi Zhou, Takeshi Matsumura, Sho Saito, Yoshitaka Yagi, Tomoaki Yoshinaga, Hiroyuki Motoshima

Biochem Biophys Res Commun· January 2026

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Autoimmune Polyglandular Syndrome Type 3 Complicated with IgG4-related Disease.
Yusuke Murata, Masaki Haneda, Nobukazu Miyakawa, Saiko Nishida, Nobuhiro Kajihara, Hiroyuki Motoshima

Intern Med· February 2024

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Hypoglycemia Induces Mitochondrial Reactive Oxygen Species Production Through Increased Fatty Acid Oxidation and Promotes Retinal Vascular Permeability in Diabetic Mice.
Ayaka Yoshinaga, Nobuhiro Kajihara, Daisuke Kukidome, Hiroyuki Motoshima, Takeshi Matsumura

Antioxid Redox Signal· June 2021

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Activation of heat shock response improves biomarkers of NAFLD in patients with metabolic diseases.
Tatsuya Kondo, Nobukazu Miyakawa, Sayaka Kitano, Takuro Watanabe, Rieko Goto, Hiroyuki Motoshima

Endocr Connect· May 2021

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The Amount of Residual Incretin Regulates the Pancreatic β-cell Function and Glucose Homeostasis.
Tatsuya Kondo, Sayaka Kitano, Nobukazu Miyakawa, Takuro Watanabe, Rieko Goto, Hiroyuki Motoshima

Intern Med· May 2021

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Rapid and dramatic glucose-lowering effect of bromocriptine in an inadequately controlled type 2 diabetes patient with prolactinoma.
Motoyuki Igata, Yoshitaka Yagi, Satoko Hanatani, Masaji Sakaguchi, Norio Ishii, Hiroyuki Motoshima

J Diabetes Investig· April 2021

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Impact of tissue macrophage proliferation on peripheral and systemic insulin resistance in obese mice with diabetes.
Yutaro Morita, Takafumi Senokuchi, Sarie Yamada, Toshiaki Wada, Tatsuya Furusho, Hiroyuki Motoshima

BMJ Open Diabetes Res Care· October 2020

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New perspectives on insulin therapy.
Eiichi Araki, Hirotaka Araki, Takafumi Senokuchi, Hiroyuki Motoshima

J Diabetes Investig· July 2020

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Inhibition of inflammation-mediated DPP-4 expression by linagliptin increases M2 macrophages in atherosclerotic lesions.
Shuhei Nishida, Takeshi Matsumura, Takafumi Senokuchi, Saiko Murakami-Nishida, Norio Ishii, Hiroyuki Motoshima

Biochem Biophys Res Commun· March 2020

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Pioglitazone suppresses macrophage proliferation in apolipoprotein-E deficient mice by activating PPARγ.
Saiko Murakami-Nishida, Takeshi Matsumura, Takafumi Senokuchi, Norio Ishii, Hiroyuki Kinoshita, Hiroyuki Motoshima

Atherosclerosis· July 2019

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Mineralocorticoid Receptor May Regulate Glucose Homeostasis through the Induction of Interleukin-6 and Glucagon-Like peptide-1 in Pancreatic Islets.
Rieko Goto, Tatsuya Kondo, Kaoru Ono, Sayaka Kitano, Nobukazu Miyakawa, Hiroyuki Motoshima

J Clin Med· May 2019

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Impacts of the 2016 Kumamoto Earthquake on glycemic control in patients with diabetes.
Tatsuya Kondo, Nobukazu Miyakawa, Hiroyuki Motoshima, Satoko Hanatani, Norio Ishii

J Diabetes Investig· March 2019

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Impact of hepatic HSP72 on insulin signaling.
Sayaka Kitano, Tatsuya Kondo, Rina Matsuyama, Kaoru Ono, Rieko Goto, Hiroyuki Motoshima

Am J Physiol Endocrinol Metab· February 2019

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Inhibition of Local Macrophage Growth Ameliorates Focal Inflammation and Suppresses Atherosclerosis.
Sarie Yamada, Takafumi Senokuchi, Takeshi Matsumura, Yutaro Morita, Norio Ishii, Hiroyuki Motoshima

Arterioscler Thromb Vasc Biol· May 2018

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Identification of microRNA that represses IRS-1 expression in liver.
Kaoru Ono, Motoyuki Igata, Tatsuya Kondo, Sayaka Kitano, Yuki Takaki, Hiroyuki Motoshima

PLoS One· March 2018

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Low glucose induces mitochondrial reactive oxygen species via fatty acid oxidation in bovine aortic endothelial cells.
Nobuhiro Kajihara, Daisuke Kukidome, Kiminori Sada, Hiroyuki Motoshima, Noboru Furukawa

J Diabetes Investig· November 2017

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Hyperglycemia Induces Cellular Hypoxia through Production of Mitochondrial ROS Followed by Suppression of Aquaporin-1.
Kiminori Sada, Takeshi Nishikawa, Daisuke Kukidome, Tomoaki Yoshinaga, Nobuhiro Kajihara, Hiroyuki Motoshima

PLoS One· July 2017

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Acetate alters expression of genes involved in beige adipogenesis in 3T3-L1 cells and obese KK-Ay mice.
Satoko Hanatani, Hiroyuki Motoshima, Yuki Takaki, Shuji Kawasaki, Motoyuki Igata

J Clin Biochem Nutr· November 2016

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Activation of heat shock response to treat obese subjects with type 2 diabetes: a prospective, frequency-escalating, randomized, open-label, triple-arm trial.
Tatsuya Kondo, Rieko Goto, Kaoru Ono, Sayaka Kitano, Mary Ann Suico, Hiroyuki Motoshima

Sci Rep· October 2016

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A 1-year, prospective, observational study of Japanese outpatients with type 1 and type 2 diabetes switching from insulin glargine or detemir to insulin degludec in basal-bolus insulin therapy (Kumamoto Insulin Degludec Observational study).
Seiya Shimoda, Miki Sato, Taiji Sekigami, Hiroyuki Motoshima, Ryohei Yoshimura

J Diabetes Investig· September 2016

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Insulin requirement profiles in Japanese hospitalized subjects with type 2 diabetes treated with basal-bolus insulin therapy.
Seiya Shimoda, Mina Okubo, Kotaro Koga, Taiji Sekigami, Junji Kawashima, Hiroyuki Motoshima

Endocr J· May 2016

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Coexistence of resistance to thyroid hormone and papillary thyroid carcinoma.
Motoyuki Igata, Kaku Tsuruzoe, Junji Kawashima, Daisuke Kukidome, Tatsuya Kondo, Hiroyuki Motoshima

Endocrinol Diabetes Metab Case Rep· May 2016

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Statins meditate anti-atherosclerotic action in smooth muscle cells by peroxisome proliferator-activated receptor-γ activation.
Kazuki Fukuda, Takeshi Matsumura, Takafumi Senokuchi, Norio Ishii, Hiroyuki Kinoshita, Hiroyuki Motoshima

Biochem Biophys Res Commun· January 2015

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Mild Electrical Stimulation with Heat Shock Reduces Visceral Adiposity and Improves Metabolic Abnormalities in Subjects with Metabolic Syndrome or Type 2 Diabetes: Randomized Crossover Trials.
Tatsuya Kondo, Kaoru Ono, Sayaka Kitano, Rina Matsuyama, Rieko Goto, Hiroyuki Motoshima

EBioMedicine· November 2014

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The role of heat shock response in insulin resistance and diabetes.
Tatsuya Kondo, Hiroyuki Motoshima, Motoyuki Igata, Junji Kawashima, Takeshi Matsumura

Diabetes Metab J· April 2014

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