Publications by authors named "Hitoshi Endou"

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Benzbromarone Analog SAR: Potent hURAT1 (SLC22A12) Inhibitors and Drug Transporter Interaction Studies.
Promsuk Jutabha, Vijay Kumar, Naohiko Anzai, Peter J Rice, Janet W Lightner, Hitoshi Endou

Drug Des Devel Ther· May 2025

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Upregulation of ATF4 mediates the cellular adaptation to pharmacologic inhibition of amino acid transporter LAT1 in pancreatic ductal adenocarcinoma cells.
Yu Ma, Suguru Okuda, Hiroki Okanishi, Minhui Xu, Chunhuan Jin, Hitoshi Endou

J Pharmacol Sci· May 2024

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Inhibition of amino acid transporter LAT1 in cancer cells suppresses G0/G1-S transition by downregulating cyclin D1 via p38 MAPK activation.
Xinyu Zhou, Ryuichi Ohgaki, Chunhuan Jin, Minhui Xu, Hiroki Okanishi, Hitoshi Endou

J Pharmacol Sci· March 2024

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JPH203, a LAT1 inhibitor, alleviates steroid-resistant murine airway inflammation mediated by Th17 cells.
Keitaro Hayashi, Mayumi Saeki, Kento Miura, Norimasa Yamasaki, Masaya Matsuda, Hitoshi Endou

Allergy· October 2023

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Retraction: Nuclear Morphometric Analysis of Leydig Cells of Male Pubertal Rats Exposed to Di(-butyl) Phthalate.
Shin Wakui, Masaya Motohashi, Takemi Satoh, Masaru Shirai, Tomoko Mutou, Hitoshi Endou

J Toxicol Pathol· October 2023

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Inhibition of cancer-type amino acid transporter LAT1 suppresses B16-F10 melanoma metastasis in mouse models.
Zitong Shi, Kazuko Kaneda-Nakashima, Ryuichi Ohgaki, Minhui Xu, Hiroki Okanishi, Hitoshi Endou

Sci Rep· August 2023

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LAT1 enables T cell activation under inflammatory conditions.
Joy Ogbechi, Helen L Wright, Stefan Balint, Louise M Topping, Zec Kristina, Hitoshi Endou

J Autoimmun· July 2023

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Combination effects of amino acid transporter LAT1 inhibitor nanvuranlat and cytotoxic anticancer drug gemcitabine on pancreatic and biliary tract cancer cells.
Kou Nishikubo, Ryuichi Ohgaki, Xingming Liu, Hiroki Okanishi, Minhui Xu, Hitoshi Endou

Cancer Cell Int· June 2023

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Engineering amino acid uptake or catabolism promotes CAR T-cell adaption to the tumor environment.
Silvia Panetti, Nicola McJannett, Livingstone Fultang, Sarah Booth, Luciana Gneo, Hitoshi Endou

Blood Adv· May 2023

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Invariant NKT cells metabolically adapt to the acute myeloid leukaemia environment.
Victoria Stavrou, Livingstone Fultang, Sarah Booth, Daniele De Simone, Arekdiusz Bartnik, Hitoshi Endou

Cancer Immunol Immunother· March 2023

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Phosphoproteomics revealed cellular signals immediately responding to disruption of cancer amino acid homeostasis induced by inhibition of L-type amino acid transporter 1.
Hiroki Okanishi, Ryuichi Ohgaki, Minhui Xu, Hitoshi Endou, Yoshikatsu Kanai

Cancer Metab· November 2022

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Pharmacologic inhibition of LAT1 predominantly suppresses transport of large neutral amino acids and downregulates global translation in cancer cells.
Kou Nishikubo, Ryuichi Ohgaki, Hiroki Okanishi, Suguru Okuda, Minhui Xu, Hitoshi Endou

J Cell Mol Med· October 2022

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LAT1-specific inhibitor ameliorates severe autoimmune arthritis in SKG mouse.
Takayoshi Owada, Kazuhiro Kurasawa, Hitoshi Endou, Tomoe Fujita, Naohiko Anzai

Int Immunopharmacol· August 2022

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Expression of L-type amino acid transporter 1 is a poor prognostic factor for Non-Hodgkin's lymphoma.
Narangerel Jigjidkhorloo, Kohsuke Kanekura, Jun Matsubayashi, Daigo Akahane, Koji Fujita, Hitoshi Endou

Sci Rep· November 2021

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Antitumor effect of dimethyl itaconate on thymic carcinoma by targeting LDHA-mTOR axis.
Keitaro Hayashi, Yoshimasa Nakazato, Motoshi Ouchi, Tomoe Fujita, Hitoshi Endou

Life Sci· October 2021

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Prognostic values of L-type amino acid transporter 1 and CD98hc expression in breast cancer.
Masaaki Ichinoe, Tetuo Mikami, Nobuyuki Yanagisawa, Tsutomu Yoshida, Kiyomi Hana, Hitoshi Endou

J Clin Pathol· September 2021

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L-type amino acid transporter 1 inhibitor suppresses murine Th2 cell-mediated bronchial hyperresponsiveness independently of eosinophil accumulation.
Daiki Ito, Kento Miura, Mayumi Saeki, Norimasa Yamasaki, Sawako Ogata, Hitoshi Endou

Asia Pac Allergy· July 2021

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Biomarker Analyses in Patients With Advanced Solid Tumors Treated With the LAT1 Inhibitor JPH203.
Naohiro Okano, Kiyomi Hana, Daisuke Naruge, Kirio Kawai, Takaaki Kobayashi, Hitoshi Endou

In Vivo· June 2021

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Proteomics and phosphoproteomics reveal key regulators associated with cytostatic effect of amino acid transporter LAT1 inhibitor.
Hiroki Okanishi, Ryuichi Ohgaki, Suguru Okuda, Hitoshi Endou, Yoshikatsu Kanai

Cancer Sci· February 2021

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Metabolic Acidosis Alters Expression of Slc22 Transporters in Mouse Kidney.
Janine Gottier Nwafor, Marta Nowik, Naohiko Anzai, Hitoshi Endou, Carsten A Wagner

Kidney Blood Press Res· November 2020

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Amino acid transporter LAT1 in tumor-associated vascular endothelium promotes angiogenesis by regulating cell proliferation and VEGF-A-dependent mTORC1 activation.
Lili Quan, Ryuichi Ohgaki, Saori Hara, Suguru Okuda, Ling Wei, Hitoshi Endou

J Exp Clin Cancer Res· November 2020

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First-in-human phase I study of JPH203, an L-type amino acid transporter 1 inhibitor, in patients with advanced solid tumors.
Naohiro Okano, Daisuke Naruge, Kirio Kawai, Takaaki Kobayashi, Fumio Nagashima, Hitoshi Endou

Invest New Drugs· October 2020

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L-type amino acid transporter 1 (LAT1)-specific inhibitor is effective against T cell-mediated nasal hyperresponsiveness.
Osamu Kaminuma, Tomoe Nishimura, Mayumi Saeki, Norimasa Yamasaki, Sawako Ogata, Hitoshi Endou

Allergol Int· July 2020

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Positive correlation of expression of L-type amino-acid transporter 1 with colorectal tumor progression and prognosis: Higher expression in sporadic colorectal tumors compared with ulcerative colitis-associated neoplasia.
Takeshi Sakata, Kiyomi Hana, Tetuo Mikami, Tutomu Yoshida, Hitoshi Endou

Pathol Res Pract· June 2020

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LAT1-specific inhibitor is effective against T cell-mediated allergic skin inflammation.
Keitaro Hayashi, Osamu Kaminuma, Tomoe Nishimura, Mayumi Saeki, Kunie Matsuoka, Hitoshi Endou

Allergy· February 2020

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