Publications by authors named "Hitoshi Ohki"

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Acceleration of Protein Degradation by 20S Proteasome-Binding Peptides Generated by In Vitro Artificial Evolution.
Yunhao Zhu, Kaishin Shigeyoshi, Yumiko Hayakawa, Sae Fujiwara, Masamichi Kishida, Hitoshi Ohki

Int J Mol Sci· December 2023

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Development of Gilteritinib-Based Chimeric Small Molecules that Potently Induce Degradation of FLT3-ITD Protein.
Nobumichi Ohoka, Masanori Suzuki, Takuya Uchida, Genichiro Tsuji, Yoshinori Tsukumo, Hitoshi Ohki

ACS Med Chem Lett· December 2022

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Development of a potent small-molecule degrader against oncogenic BRAF protein that evades paradoxical MAPK activation.
Nobumichi Ohoka, Masanori Suzuki, Takuya Uchida, Yoshinori Tsukumo, Masayuki Yoshida, Hitoshi Ohki

Cancer Sci· August 2022

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Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with in Vivo Antitumor Activity.
Junya Kawai, Tadashi Toki, Masahiro Ota, Hidekazu Inoue, Yoshimi Takata, Hitoshi Ohki

J Med Chem· November 2019

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Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold.
Junya Kawai, Masahiro Ota, Hitoshi Ohki, Tadashi Toki, Makoto Suzuki

ACS Med Chem Lett· June 2019

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Discovery of DF-461, a Potent Squalene Synthase Inhibitor.
Masanori Ichikawa, Masami Ohtsuka, Hitoshi Ohki, Masahiro Ota, Noriyasu Haginoya

ACS Med Chem Lett· October 2013

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Discovery of novel tricyclic compounds as squalene synthase inhibitors.
Masanori Ichikawa, Masami Ohtsuka, Hitoshi Ohki, Noriyasu Haginoya, Masao Itoh

Bioorg Med Chem· May 2012

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Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria.
Rie Miyauchi, Katsuhiro Kawakami, Masao Ito, Norikazu Matsuhashi, Hitoshi Ohki

Bioorg Med Chem· October 2009

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Systematic research of peptide spacers controlling drug release from macromolecular prodrug system, carboxymethyldextran polyalcohol-peptide-drug conjugates.
Yoshinobu Shiose, Hiroshi Kuga, Hitoshi Ohki, Masahiro Ikeda, Fumiyoshi Yamashita

Bioconjug Chem· January 2009

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Synthesis and structure-activity relationships of 5-amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolonecarboxylic acid antibacterials having fluorinated 7-[(3R)-3-(1-aminocyclopropan-1-yl)pyrrolidin-1-yl] substituents.
Hiroaki Inagaki, Satoru Miyauchi, Rie N Miyauchi, Haruko C Kawato, Hitoshi Ohki

J Med Chem· March 2003

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Synthesis and mechanism of action of novel pyrimidinyl pyrazole derivatives possessing antiproliferative activity.
Hitoshi Ohki, Kenji Hirotani, Hiroyuki Naito, Satoru Ohsuki, Megumi Minami

Bioorg Med Chem Lett· November 2002

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