Publications by authors named "Holger Flechsig"

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Simple mechanics of protein machines.
Holger Flechsig, Alexander S Mikhailov

J R Soc Interface· June 2019

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Ligand Binding to the Membrane-Distal Domain of the Met Receptor Induces Dimerization at the Membrane-Proximal Domain.
Neval Yilmaz, Hiroki Tanino, Shun Sakuraba, Romain Amyot, Holger Flechsig

ACS Nano· December 2025

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MET Enhances Amivantamab Binding to EGFR and Antibody-Dependent Cellular Toxicity.
Shigeki Sato, Neval Yilmaz, Sachiko Arai, Katsuya Sakai, Hiroki Sato, Holger Flechsig

Cancer Sci· November 2025

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Flexible Fitting to Infer Atomistic-Precision Models of Large-Amplitude Conformational Dynamics in Biomolecules from High-Speed Atomic Force Microscopy Imaging.
Romain Amyot, Osamu Miyashita, Xuan Wu, Kazusa Takeda, Noriyuki Kodera, Holger Flechsig

ACS Nano· September 2025

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High-Speed Atomic Force Microscopy Reveals Fluctuations and Dimer Splitting of the N-Terminal Domain of GluA2 Ionotropic Glutamate Receptor-Auxiliary Subunit Complex.
Ayumi Sumino, Takashi Sumikama, Yimeng Zhao, Holger Flechsig, Kenichi Umeda

ACS Nano· September 2024

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High-Speed Atomic Force Microscopy for Filming Protein Molecules in Dynamic Action.
Toshio Ando, Shingo Fukuda, Kien X Ngo, Holger Flechsig

Annu Rev Biophys· July 2024

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Observing Dynamic Conformational Changes within the Coiled-Coil Domain of Different Laminin Isoforms Using High-Speed Atomic Force Microscopy.
Lucky Akter, Holger Flechsig, Arin Marchesi, Clemens M Franz

Int J Mol Sci· February 2024

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Structural heterogeneity of the ion and lipid channel TMEM16F.
Zhongjie Ye, Nicola Galvanetto, Leonardo Puppulin, Simone Pifferi, Holger Flechsig

Nat Commun· January 2024

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Structural Dynamics of E6AP E3 Ligase HECT Domain and Involvement of a Flexible Hinge Loop in the Ubiquitin Chain Synthesis Mechanism.
Kazusa Takeda, Holger Flechsig, Ikumi Muro, Romain Amyot, Fuminori Kobayashi

Nano Lett· December 2023

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Computational biophysics of atomic force microscopy-an IUPAB-sponsored workshop.
Damien Hall, Holger Flechsig, Takashi Sumikama

Biophys Rev· December 2023

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Predicting the placement of biomolecular structures on AFM substrates based on electrostatic interactions.
Romain Amyot, Kaho Nakamoto, Noriyuki Kodera, Holger Flechsig

Front Mol Biosci· November 2023

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Protein dynamics by the combination of high-speed AFM and computational modeling.
Holger Flechsig, Toshio Ando

Curr Opin Struct Biol· June 2023

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Imaging single CaMKII holoenzymes at work by high-speed atomic force microscopy.
Shotaro Tsujioka, Ayumi Sumino, Yutaro Nagasawa, Takashi Sumikama, Holger Flechsig

Sci Adv· June 2023

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Dynamics of Target DNA Binding and Cleavage by Cas9 as Revealed by High-Speed Atomic Force Microscopy.
Leonardo Puppulin, Junichiro Ishikawa, Ayumi Sumino, Arin Marchesi, Holger Flechsig

ACS Nano· March 2023

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BioAFMviewer software for simulation atomic force microscopy of molecular structures and conformational dynamics.
Romain Amyot, Noriyuki Kodera, Holger Flechsig

J Struct Biol X· February 2023

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Issue Focus call: Computational biophysics of atomic force microscopy.
Takashi Sumikama, Damien Hall, Holger Flechsig

Biophys Rev· February 2023

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Importance of annexin V N-terminus for 2D crystal formation and quick purification protocol of recombinant annexin V.
Ryusei Yamada, Tran Ngoc Trang, Holger Flechsig, Toshiki Takeda, Noriyuki Kodera

PLoS One· December 2022

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Novel DNA Aptamer for CYP24A1 Inhibition with Enhanced Antiproliferative Activity in Cancer Cells.
Madhu Biyani, Kaori Yasuda, Yasuhiro Isogai, Yuki Okamoto, Wei Weilin, Holger Flechsig

ACS Appl Mater Interfaces· April 2022

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Simulation atomic force microscopy for atomic reconstruction of biomolecular structures from resolution-limited experimental images.
Romain Amyot, Arin Marchesi, Clemens M Franz, Ignacio Casuso, Holger Flechsig

PLoS Comput Biol· March 2022

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An ultra-wide scanner for large-area high-speed atomic force microscopy with megapixel resolution.
Arin Marchesi, Kenichi Umeda, Takumi Komekawa, Takeru Matsubara, Holger Flechsig

Sci Rep· June 2021

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BioAFMviewer: An interactive interface for simulated AFM scanning of biomolecular structures and dynamics.
Romain Amyot, Holger Flechsig

PLoS Comput Biol· November 2020

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Allosteric communication in molecular machines via information exchange: what can be learned from dynamical modeling.
Dimitri Loutchko, Holger Flechsig

Biophys Rev· April 2020

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Analyzing Fluctuation Properties in Protein Elastic Networks with Sequence-Specific and Distance-Dependent Interactions.
Romain Amyot, Yuichi Togashi, Holger Flechsig

Biomolecules· September 2019

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Coarse-Grained Protein Dynamics Studies Using Elastic Network Models.
Yuichi Togashi, Holger Flechsig

Int J Mol Sci· December 2018

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Designed Elastic Networks: Models of Complex Protein Machinery.
Holger Flechsig, Yuichi Togashi

Int J Mol Sci· October 2018

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