Publications by authors named "Hong-can Ren"

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Assessing DDI risks in drug discovery and development: approaches, challenges, and trends.
Hong-Can Ren, Chunyong He, Hong Wan

Expert Opin Drug Metab Toxicol· December 2025

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Editorial: Application of PKPD modeling in drug discovery and development.
Hong-Can Ren, Xiao Zhu, Kun Hao, Si-Yuan Le

Front Pharmacol· June 2025

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High-performance PBPK model for predicting CYP3A4 induction-mediated drug interactions: a refined and validated approach.
Cheng-Guang Yang, Tao Chen, Wen-Teng Si, An-Hai Wang, Hong-Can Ren

Front Pharmacol· February 2025

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Preclinical metabolism and disposition of [C]GFH009, a novel selective CDK9 inhibitor.
Li Wang, Jin-Zhu Zhao, Fu-Sheng Zhou, Jiong Lan, Qiang Lu, Hong-Can Ren

Xenobiotica· October 2024

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Development and validation of a sensitive UPLC-MS/MS analytical method for GFH009 in rat plasma and its application to toxicokinetics studies.
Qiang Liu, Jin-Zhu Zhao, Fu-Sheng Zhou, Jiong Lan, Qiang Lu, Hong-Can Ren

Biomed Chromatogr· February 2024

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Enhancing drug-drug Interaction Prediction by Integrating Physiologically-Based Pharmacokinetic Model with Fraction Metabolized by CYP3A4.
Pin Jiang, Tao Chen, Lin-Feng Chu, Ren-Peng Xu, Jin-Ting Gao, Hong-Can Ren

Expert Opin Drug Metab Toxicol· November 2023

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Mechanism-Based Pharmacokinetic Model for the Deglycosylation Kinetics of 20(S)-Ginsenosides Rh2.
Hong-Can Ren, Jian-Guo Sun, Ji-Ye A, Sheng-Hua Gu, Jian Shi

Front Pharmacol· May 2022

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Predicting the Drug-Drug Interaction Mediated by CYP3A4 Inhibition: Method Development and Performance Evaluation.
Hong-Can Ren, Yang Sai, Tao Chen, Chun Zhang, Lily Tang

AAPS J· December 2021

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Evaluation of Generic Methods to Predict Human Pharmacokinetics Using Physiologically Based Pharmacokinetic Model for Early Drug Discovery of Tyrosine Kinase Inhibitors.
Hong-Can Ren, Yang Sai, Tao Chen

Eur J Drug Metab Pharmacokinet· February 2019

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Correction to: Evaluation of Generic Methods to Predict Human Pharmacokinetics Using Physiologically Based Pharmacokinetic Model for Early Drug Discovery of Tyrosine Kinase Inhibitors.
Hong-Can Ren, Yang Sai, Tao Chen

Eur J Drug Metab Pharmacokinet· February 2019

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Sensitive determination of 20(S)-protopanaxadiol in rat plasma using HPLC-APCI-MS: application of pharmacokinetic study in rats.
Hong-Can Ren, Jian-Guo Sun, Guang-Ji Wang, Ji-Ye A, Hai-Tang Xie

J Pharm Biomed Anal· December 2008

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Simultaneous determination of GFA and its active metabolites in human plasma by liquid chromatography electrospray ionization mass spectrometry and its application to pharmacokinetic studies.
Qing Huang, Guang-Ji Wang, Jian-Guo Sun, Ji-Ye A, Wei-Bin Zha, Hong-Can Ren

J Pharm Biomed Anal· March 2008

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Pharmacokinetic study with N-Ile1-Thr2-63-desulfato-r-hirudin in rabbits by means of bioassay.
Guo-zhu Han, Hong-can Ren, Yong Lu, Ying Li, Shu Xiao

J Zhejiang Univ Sci B· March 2006

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