Publications by authors named "Hongfeng Gu"

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Discovery of PKMYT1 Inhibitors with a Novel Scaffold for the Treatment of Triple-Negative Breast Cancer.
Jingling Huang, Peixuan Li, Feihuang Qiu, Yingming Fu, Wenxin Yan, Hongfeng Gu

J Med Chem· December 2025

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Discovery of Novel and Highly Potent Wee1 and HDAC Dual-Target Inhibitors for the Treatment of Acute Myeloid Leukemia.
Wenhui Zhang, Wenxin Yan, Tianyi Wei, Sai Che, Yangqian Sun, Hongfeng Gu

J Med Chem· November 2025

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PARP7: an Emerging Therapeutic Target-Insights into Biological Functions and Advances in Small-Molecule Inhibitor Development.
Feihuang Qiu, Jianqiao Wang, Kehan Huang, Tianxiang Shang, Chenghao Wang, Hongfeng Gu

J Med Chem· October 2025

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Engineered mesenchymal stem cell-derived extracellular vesicles overexpressing miR-146a alleviate neuroinflammation in Alzheimer's disease.
Jia Zhang, Siqi He, Qiguo Xiao, Weijie Jiang, Bo Wang, Hongfeng Gu

Neural Regen Res· September 2025

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Discovery of Orally Potent Small-Molecule CD73 Inhibitor for Cancer Immunotherapy.
Lifang Cen, Weijie Ren, Jiajie Yu, Ming Cheng, Xiangying Kong, Hongfeng Gu

J Med Chem· June 2025

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Xiong's Shiwei Wendan decoction attenuates plaque lesions and balances gut microbiota dysbiosis in ApoE-/- mice with high-fat diet.
Liu Qian, Xiao Liuchen, Yuan Yue, Dang Xiaopeng, Wen Jie

J Tradit Chin Med· June 2025

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Discovery and Optimization of Potent and Highly Selective PARP14 Inhibitors for the Treatment of Atopic Dermatitis.
Shiqi Wu, Xiaorong Zeng, Jing Liu, Kaiyuan Cong, Shaoxue Lou, Hongfeng Gu, Guangwei He

J Med Chem· May 2025

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Discovery and Optimization of Novel Apo-IDO1 Inhibitors by a Pharmacophore-Based Structural Simplification Strategy.
Lifang Cen, Yunze Wu, Mingchao He, Jingling Huang, Weijie Ren, Hongfeng Gu

J Med Chem· March 2025

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Acidosis induces autophagic cell death through ASIC1-mediated Akt/mTOR signaling in HT22 neurons.
Miao Guo, Ming-Yue Qiu, Lin Zeng, Ya-Xiong Nie, Ya-Ling Tang, Hong-Feng Gu

Toxicology· February 2025

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Gut Microbiota Metabolites Mediate Bax to Reduce Neuronal Apoptosis via cGAS/STING Axis in Epilepsy.
Jinxia Zhai, Chao Wang, Liang Jin, Fangtao Liu, Yinzhu Xiao, Hongfeng Gu

Mol Neurobiol· December 2024

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New TIPARP inhibitor rescues mitochondrial function and brain injury in ischemic stroke.
Yang Cai, Hongfeng Gu, Lu Li, Xue Liu, Ying Bai

Pharmacol Res· December 2024

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Discovery of cyanoguanidine derivatives as biased μ-opioid receptor agonists.
Liang-Han Zhu, Hui-Huan Mao, Mingchao He, Zhi-Ying Cui, Qi-Hua Zhu, Hong-Feng Gu

Bioorg Med Chem· November 2024

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ASIC1/RIP1 accelerates atherosclerosis via disrupting lipophagy.
Yuan-Mei Wang, Huang Tang, Ya-Jie Tang, Juan Liu, Yu-Fang Yin, Yao-Guang Feng, Hong-Feng Gu

J Adv Res· September 2024

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Discovery of highly potent PARP7 inhibitors for cancer immunotherapy.
Jieping Yang, Beibei Liu, Wenxin Yan, Xiaolin Zhao, Chenghao Wang, Hongfeng Gu

Bioorg Chem· July 2024

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Discovery of the first ataxia telangiectasia and Rad3-related (ATR) degraders for cancer treatment.
Lei Huang, Jialu Shao, Wenwen Lai, Hongfeng Gu, Jieping Yang

Eur J Med Chem· March 2024

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Discovery of Highly Potent Small-Molecule PD-1/PD-L1 Inhibitors with a Novel Scaffold for Cancer Immunotherapy.
Yongling Xu, Huijie Du, Weibo Guo, Beibei Liu, Wenxin Yan, Hongfeng Gu

J Med Chem· March 2024

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Artemisinin ameliorates cognitive decline by inhibiting hippocampal neuronal ferroptosis via Nrf2 activation in T2DM mice.
Bo Wang, Sheng Zhu, Miao Guo, Run-Dong Ma, Ya-Ling Tang, Hong-Feng Gu

Mol Med· March 2024

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Discovery of Highly Selective PARP7 Inhibitors with a Novel Scaffold for Cancer Immunotherapy.
Hongfeng Gu, Wenxin Yan, Jieping Yang, Beibei Liu, Xiaolin Zhao

J Med Chem· February 2024

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Discovery of the Potent and Highly Selective PARP7 Inhibitor as a Novel Immunotherapeutic Agent for Tumors.
Hongfeng Gu, Wenxin Yan, Yong Wang, Wenbo Xu, Lei Huang

J Med Chem· January 2023

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Acid-Sensing Ion Channel 1/Calpain1 Activation Impedes Macrophage ATP-Binding Cassette Protein A1-Mediated Cholesterol Efflux Induced by Extracellular Acidification.
Yuan-Mei Wang, Mo-Ye Tan, Rong-Jie Zhang, Ming-Yue Qiu, You-Sheng Fu, Hong-Feng Gu

Front Physiol· January 2022

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Critical role of dysfunctional mitochondria and defective mitophagy in autism spectrum disorders.
Yuan-Mei Wang, Ming-Yue Qiu, Qing Liu, Huang Tang, Hong-Feng Gu

Brain Res Bull· March 2021

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Lipophagy in atherosclerosis.
Qing Liu, Yuan-Mei Wang, Hong-Feng Gu

Clin Chim Acta· December 2020

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Hydrogen Sulfide Ameliorates Cognitive Dysfunction in Formaldehyde-Exposed Rats: Involvement in the Upregulation of Brain-Derived Neurotrophic Factor.
Xiang Li, Yuan-Yuan Zhuang, Lei Wu, Ming Xie, Hong-Feng Gu

Neuropsychobiology· November 2020

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Autophagy in chronic stress induced atherosclerosis.
Na Li, Ru-Xin Zhang, Xue-Jiao Xie, Hong-Feng Gu

Clin Chim Acta· April 2020

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Acid-sensing ion channels: Linking extracellular acidification with atherosclerosis.
Rong-Jie Zhang, Yu-Fang Yin, Xue-Jiao Xie, Hong-Feng Gu

Clin Chim Acta· March 2020

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