Publications by authors named "Hongkui Deng"

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β-galactosidase-targeted senolytic prodrug ameliorates preclinical models of post-traumatic osteoarthritis.
Qi Li, Tong Wu, Yifei Fan, Jin Cheng, Junyan Wang, Hongkui Deng

EBioMedicine· December 2025

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IL-12 and GM-CSF engineered dendritic cells enhance the enrichment and selection of tumor-reactive T cells for cancer immunotherapy.
Zhen Liu, Haoyun Li, Zhaoya Gao, Ruoqi Cheng, Jiahua Lu, Hongkui Deng

Front Immunol· December 2025

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A continuous totipotent-like cell-based embryo model recapitulates mouse embryogenesis from zygotic genome activation to gastrulation.
Yixuan Ren, Xuyang Wang, Haiyin Liu, Yaxing Xu, Ruoqi Cheng, Hongkui Deng

Nat Cell Biol· November 2025

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A patient-derived organoid model captures fetal-like plasticity in colorectal cancer.
Liang Xiong, Ying Xu, Zhaoya Gao, Jingyi Shi, Yunfan Wang, Hongkui Deng

Cell Res· September 2025

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Reconstruction of endocrine subtype-complete human pluripotent stem cell-derived islets with capacity for hypoglycemia protection in vivo.
Gaofan Meng, Jiabin Gu, Soon Yi Liew, Jingxiao Cao, Zhihui Wang, Hongkui Deng

Cell Stem Cell· September 2025

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Improved identification of tumor-specific TCRs from circulating lymphocytes using autologous colorectal tumor organoids.
Lisha Ma, Xiya Wang, Qianjing Zhang, Zhaoya Gao, Xiangwen Ji, Hongkui Deng

Cancer Lett· September 2025

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CRISPR-based screening identifies the role of KRAB-containing transcription factors ZIM3 and ZNF394 in human major zygotic genome activation.
Jiayu Li, Liangfu Xie, Cheng Shi, Tiantian Zhang, Xiwen Lin, Hongkui Deng

Cell Rep· August 2025

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Chemical reprogramming of human blood cells to pluripotent stem cells.
Fangqi Peng, Yanglu Wang, Lin Cheng, Ruyi Cai, Xiaodi Fu, Hongkui Deng

Cell Stem Cell· August 2025

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Trophectoderm-like cells from EPS cells enable generating EPS cell-derived post-implantation embryoids that complete gastrulation.
Xuyang Wang, Ruoqi Cheng, Chenyang Wu, Haiyin Liu, Zining Li, Hongkui Deng

Protein Cell· August 2025

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A rapid chemical reprogramming system to generate human pluripotent stem cells.
Yanglu Wang, Fangqi Peng, Zhihan Yang, Lin Cheng, Jingxiao Cao, Hongkui Deng

Nat Chem Biol· July 2025

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Human embryo research: how to move towards a 28-day limit.
Alejandro De Los Angeles, Nissim Benvenisty, Hongkui Deng, Jacob H Hanna, Julian Koplin

Nature· July 2025

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Bioprinting functional hepatocyte organoids derived from human chemically induced pluripotent stem cells to treat liver failure.
Guangya Li, Jianyu He, Jihang Shi, Xinyi Li, Lulu Liu, Hongkui Deng

Gut· June 2025

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Decoding human chemical reprogramming: mechanisms and principles.
Lin Cheng, Yanglu Wang, Jingyang Guan, Hongkui Deng

Trends Biochem Sci· June 2025

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Transient chemical-mediated epigenetic modulation confers unrestricted lineage potential on human primed pluripotent stem cells.
Shi Chen, Yuanyuan He, Lejun Lv, Bei Liu, Cheng Li, Hongkui Deng

Sci China Life Sci· April 2025

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Single-cell transcriptomics reveals liver developmental trajectory during lineage reprogramming of human induced hepatocyte-like cells.
Nan Jiang, Guangya Li, Sen Luo, Xi Kong, Shigang Yin, Hongkui Deng

Cell Mol Life Sci· April 2025

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TLR7/8 signaling activation enhances the potency of human pluripotent stem cell-derived eosinophils in cancer immunotherapy for solid tumors.
Sheng Zhu, Zhengyang Zhou, Ruixin Gu, Zixin Zhao, Yingfeng Zhang, Hongkui Deng

Exp Hematol Oncol· March 2025

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Potentiating CAR-T cell function in the immunosuppressive tumor microenvironment by inverting the TGF-β signal.
Shen Zheng, Xuan Che, Kai Zhang, Yun Bai, Hongkui Deng

Mol Ther· February 2025

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Pluripotent stem cell-based immunotherapy: advances in translational research, cell differentiation, and gene modifications.
Qi Lei, Hongkui Deng, Shicheng Sun

Life Med· February 2025

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Generation of human expandable limb-bud-like progenitors via chemically induced dedifferentiation.
Jialiang Zhu, Xinxing Zhong, Huanjing He, Jingxiao Cao, Zhengyang Zhou, Hongkui Deng

Cell Stem Cell· December 2024

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Generation of dual-attribute iTNK cells from hPSCs for cancer immunotherapy.
Yingfeng Zhang, Yuanyuan He, Chenyi Dai, Zhengyang Zhou, Yudi Miao, Hongkui Deng

Cell Rep Methods· September 2024

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A two-step strategy to expand primary human hepatocytes in vitro with efficient metabolic and regenerative capacities.
Huangfan Xie, Guangya Li, Yunxi Fu, Nan Jiang, Simeng Yi, Hongkui Deng

Stem Cell Res Ther· September 2024

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Identification and validation of tumor-specific T cell receptors from tumor infiltrating lymphocytes using tumor organoid co-cultures.
Zhilang Li, Lisha Ma, Zhaoya Gao, Xiya Wang, Xuan Che, Hongkui Deng

Cancer Immunol Immunother· July 2024

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Remodeling ceramide homeostasis promotes functional maturation of human pluripotent stem cell-derived β cells.
Huijuan Hua, Yaqi Wang, Xiaofeng Wang, Shusen Wang, Yunlu Zhou, Hongkui Deng

Cell Stem Cell· June 2024

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An effective pharmacological hydrogel induces optic nerve repair and improves visual function.
Lipeng Wang, Shan Zhang, Yawen Han, Shuo Tang, Jiarui Li, Hongkui Deng

Sci China Life Sci· March 2024

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