Publications by authors named "Huawei Qiu"

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The Efficacy and Safety of Hypoglycemic Agents in the Middle-Aged and Elderly Patients with Diabetes Mellitus: A Systematic Review and Meta-Analysis.
Jiayan Huang, Huawei Qiu, Kaishun Meng

Iran J Public Health· July 2025

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Role of P-glycoprotein in Regulating the Efficacy, Toxicity and Pharmacokinetics of Yunaconitine.
Xiaocui Li, Qi Liang, Caiyan Wang, Huawei Qiu, Tingting Lin, Zhongqiu Liu

Curr Drug Metab· November 2024

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Salvianolic acid F suppresses KRAS-dependent lung cancer cell growth through the PI3K/AKT signaling pathway.
Xuenan Hou, Chishun Zhou, Zuhui Liang, Huawei Qiu, Zhuming Zhou

Phytomedicine· December 2023

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XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody, demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer.
Kurt A Jenkins, Miso Park, Magali Pederzoli-Ribeil, Ugur Eskiocak, Parker Johnson, Huawei Qiu

J Immunother Cancer· December 2023

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Insight into the mechanism of Xiao-Chai-Hu-Tang alleviates irinotecan-induced diarrhea based on regulating the gut microbiota and inhibiting Gut β-GUS.
Caiyan Wang, Xiaojun Teng, Chuang Wang, Binjie Liu, Runze Zhou, Huawei Qiu, Zhongqiu Liu

Phytomedicine· November 2023

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Clinical poisoning events involving yunaconitine may be highly correlated with metabolism-based interactions: A critical role of CYP3A4.
Xiaocui Li, Yu Fu, Huawei Qiu, Xueyu Xu, Tingting Lin, Zhongqiu Liu

Food Chem Toxicol· September 2023

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Neoline, fuziline, songorine and 10-OH mesaconitine are potential quality markers of Fuzi: In vitro and in vivo explorations as well as pharmacokinetics, efficacy and toxicity evaluations.
Xiaocui Li, Weiqing Hou, Tingting Lin, Jiadong Ni, Huawei Qiu, Zhongqiu Liu

J Ethnopharmacol· March 2023

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Publisher Correction: A trispecific antibody targeting HER2 and T cells inhibits breast cancer growth via CD4 cells.
Edward Seung, Zhen Xing, Lan Wu, Ercole Rao, Virna Cortez-Retamozo, Huawei Qiu

Nature· April 2022

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A trispecific antibody targeting HER2 and T cells inhibits breast cancer growth via CD4 cells.
Edward Seung, Zhen Xing, Lan Wu, Ercole Rao, Virna Cortez-Retamozo, Huawei Qiu

Nature· March 2022

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Pharmacokinetics of novel Fc-engineered monoclonal and multispecific antibodies in cynomolgus monkeys and humanized FcRn transgenic mouse models.
Delphine Valente, Christine Mauriac, Thorsten Schmidt, Ingo Focken, Jochen Beninga, Huawei Qiu

MAbs· August 2021

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Engineered Fc-glycosylation switch to eliminate antibody effector function.
Qun Zhou, Julie Jaworski, Yanfeng Zhou, Delphine Valente, Joanne Cotton, Huawei Qiu

MAbs· July 2021

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Site-Specific Antibody Conjugation to Engineered Double Cysteine Residues.
Qun Zhou, Josephine Kyazike, Ekaterina Boudanova, Michael Drzyzga, Denise Honey, Huawei Qiu

Pharmaceuticals (Basel)· July 2021

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Combined inhibition of ACK1 and AKT shows potential toward targeted therapy against KRAS-mutant non-small-cell lung cancer.
Xiangjing Yu, Jie Liu, Huawei Qiu, Huiting Hao, Jinhong Zhu

Bosn J Basic Med Sci· April 2021

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A highly potent CD73 biparatopic antibody blocks organization of the enzyme active site through dual mechanisms.
James E Stefano, Dana M Lord, Yanfeng Zhou, Julie Jaworski, Joern Hopke, Huawei Qiu

J Biol Chem· December 2020

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Mapping of a Novel H3-Specific Broadly Neutralizing Monoclonal Antibody Targeting the Hemagglutinin Globular Head Isolated from an Elite Influenza Virus-Immunized Donor Exhibiting Serological Breadth.
Yu Qiu, Svetlana Stegalkina, Jianxin Zhang, Ekaterina Boudanova, Anna Park, Huawei Qiu

J Virol· February 2020

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biAb Mediated Restoration of the Linkage between Dystroglycan and Laminin-211 as a Therapeutic Approach for α-Dystroglycanopathies.
Nathan Gumlaw, Leila M Sevigny, Hongmei Zhao, Zhengyu Luo, Dinesh S Bangari, Huawei Qiu

Mol Ther· February 2020

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Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation.
Lan Wu, Edward Seung, Ling Xu, Ercole Rao, Dana M Lord, Huawei Qiu

Nat Cancer· January 2020

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Engineering an anti-CD52 antibody for enhanced deamidation stability.
Huawei Qiu, Ronnie Wei, Julie Jaworski, Ekaterina Boudanova, Heather Hughes

MAbs· October 2019

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Antibody Fc engineering for enhanced neonatal Fc receptor binding and prolonged circulation half-life.
Brian C Mackness, Julie A Jaworski, Ekaterina Boudanova, Anna Park, Delphine Valente, Huawei Qiu

MAbs· October 2019

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The Mechanistic Impact of N-Glycosylation on Stability, Pharmacokinetics, and Immunogenicity of Therapeutic Proteins.
Qun Zhou, Huawei Qiu

J Pharm Sci· April 2019

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Structure-based engineering to restore high affinity binding of an isoform-selective anti-TGFβ1 antibody.
Dana M Lord, Julie J Bird, Denise M Honey, Annie Best, Anna Park, Huawei Qiu

MAbs· April 2018

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Engineering Aglycosylated IgG Variants with Wild-Type or Improved Binding Affinity to Human Fc Gamma RIIA and Fc Gamma RIIIAs.
Tiffany F Chen, Stephen L Sazinsky, Damian Houde, David J DiLillo, Julie Bird, Huawei Qiu

J Mol Biol· August 2017

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Human acid sphingomyelinase structures provide insight to molecular basis of Niemann-Pick disease.
Yan-Feng Zhou, Matthew C Metcalf, Scott C Garman, Tim Edmunds, Huawei Qiu

Nat Commun· October 2016

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Impact of cysteine variants on the structure, activity, and stability of recombinant human α-galactosidase A.
Huawei Qiu, Denise M Honey, Jonathan S Kingsbury, Anna Park, Ekaterina Boudanova

Protein Sci· September 2015

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Structures of a pan-specific antagonist antibody complexed to different isoforms of TGFβ reveal structural plasticity of antibody-antigen interactions.
Aaron Moulin, Magali Mathieu, Catherine Lawrence, Russell Bigelow, Mark Levine, Huawei Qiu

Protein Sci· December 2014

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