Publications by authors named "Hubert Maehr"

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Analysis of the Transcriptome: Regulation of Cancer Stemness in Breast Ductal Carcinoma by Vitamin D Compounds.
Naing Lin Shan, Audrey Minden, Philip Furmanski, Min Ji Bak, Li Cai, Hubert Maehr

Cancer Prev Res (Phila)· August 2020

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Structural analysis and biological activities of BXL0124, a gemini analog of vitamin D.
Anna Y Belorusova, Nanjoo Suh, Hong Jin Lee, Jae Young So, Hubert Maehr

J Steroid Biochem Mol Biol· October 2017

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Vitamin D compounds inhibit cancer stem-like cells and induce differentiation in triple negative breast cancer.
Naing Lin Shan, Joseph Wahler, Hong Jin Lee, Min Ji Bak, Soumyasri Das Gupta, Hubert Maehr

J Steroid Biochem Mol Biol· October 2017

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Vitamin D compounds reduce mammosphere formation and decrease expression of putative stem cell markers in breast cancer.
Joseph Wahler, Jae Young So, Larry C Cheng, Hubert Maehr, Milan Uskokovic

J Steroid Biochem Mol Biol· April 2015

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HES1-mediated inhibition of Notch1 signaling by a Gemini vitamin D analog leads to decreased CD44(+)/CD24(-/low) tumor-initiating subpopulation in basal-like breast cancer.
Jae Young So, Joseph Wahler, Soumyasri Das Gupta, David M Salerno, Hubert Maehr

J Steroid Biochem Mol Biol· April 2015

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Inhibition of the transition of ductal carcinoma in situ to invasive ductal carcinoma by a Gemini vitamin D analog.
Joseph Wahler, Jae Young So, Yeoun Chan Kim, Fang Liu, Hubert Maehr

Cancer Prev Res (Phila)· June 2014

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Oral administration of a gemini vitamin D analog, a synthetic triterpenoid and the combination prevents mammary tumorigenesis driven by ErbB2 overexpression.
Jae Young So, Joseph E Wahler, Taesook Yoon, Amanda K Smolarek, Yong Lin, Hubert Maehr

Cancer Prev Res (Phila)· September 2013

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Targeting CD44-STAT3 signaling by Gemini vitamin D analog leads to inhibition of invasion in basal-like breast cancer.
Jae Young So, Amanda K Smolarek, David M Salerno, Hubert Maehr, Milan Uskokovic

PLoS One· July 2013

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Diastereotopic and deuterium effects in gemini.
Hubert Maehr, Natacha Rochel, Hong Jin Lee, Nanjoo Suh, Milan R Uskokovic

J Med Chem· May 2013

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A novel Gemini vitamin D analog represses the expression of a stem cell marker CD44 in breast cancer.
Jae Young So, Hong Jin Lee, Amanda K Smolarek, Shiby Paul, Chung-Xiou Wang, Hubert Maehr

Mol Pharmacol· March 2011

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Structure-function study of gemini derivatives with two different side chains at C-20, Gemini-0072 and Gemini-0097.
Tiphaine Huet, Hubert Maehr, Hong Jin Lee, Milan R Uskokovic, Nanjoo Suh

Medchemcomm· January 2011

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Gemini vitamin D analog suppresses ErbB2-positive mammary tumor growth via inhibition of ErbB2/AKT/ERK signaling.
Hong Jin Lee, Jae-Young So, Andrew DeCastro, Amanda Smolarek, Shiby Paul, Hubert Maehr

J Steroid Biochem Mol Biol· July 2010

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Calcitriol derivatives with two different side chains at C-20. V. Potent inhibitors of mammary carcinogenesis and inducers of leukemia differentiation.
Hubert Maehr, Hong Jin Lee, Bradford Perry, Nanjoo Suh, Milan R Uskokovic

J Med Chem· September 2009

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Synthesis and anti-inflammatory properties of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-24-oxo-vitamin D3, a hypocalcemic, stable metabolite of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-vitamin D3.
Gilles Laverny, Giuseppe Penna, Milan Uskokovic, Stanislaw Marczak, Hubert Maehr

J Med Chem· April 2009

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Novel Gemini vitamin D(3) analogs have potent antitumor activity.
Tsuyako Saito, Ryoko Okamoto, Talin Haritunians, James O'Kelly, Milan Uskokovic, Hubert Maehr

J Steroid Biochem Mol Biol· November 2008

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Gemini vitamin D analogues inhibit estrogen receptor-positive and estrogen receptor-negative mammary tumorigenesis without hypercalcemic toxicity.
Hong Jin Lee, Shiby Paul, Nadi Atalla, Paul E Thomas, Xinjie Lin, Hubert Maehr

Cancer Prev Res (Phila)· November 2008

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Activation of bone morphogenetic protein signaling by a Gemini vitamin D3 analogue is mediated by Ras/protein kinase C alpha.
Hong Jin Lee, Yan Ji, Shiby Paul, Hubert Maehr, Milan Uskokovic

Cancer Res· December 2007

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Calcitriol derivatives with two different side-chains at C-20. Part 4: further chain modifications that alter VDR-dependent monocytic differentiation potency in human leukemia cells.
Edward Garay, Pawel Jankowski, Paulo Lizano, Stanislaw Marczak, Hubert Maehr

Bioorg Med Chem· July 2007

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Calcitriol derivatives with two different side chains at C-20 III. An epimeric pair of the gemini family with unprecedented antiproliferative effects on tumor cells and renin mRNA expression inhibition.
Hubert Maehr, Milan Uskokovic, Luciano Adorini, Giuseppe Penna, Roberto Mariani

J Steroid Biochem Mol Biol· March 2007

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Vitamin D and its binding protein: challenges and opportunities for drug research.
Hubert Maehr

Curr Top Med Chem· February 2007

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C-20 cyclopropyl vitamin D3 analogs.
Milan R Uskokovic, Percy Manchand, Stanislaw Marczak, Hubert Maehr, Pawel Jankowski

Curr Top Med Chem· February 2007

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Gene expression profiling changes induced by a novel Gemini Vitamin D derivative during the progression of breast cancer.
Hong Jin Lee, Hao Liu, Catherine Goodman, Yan Ji, Hubert Maehr

Biochem Pharmacol· July 2006

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A novel vitamin D derivative activates bone morphogenetic protein signaling in MCF10 breast epithelial cells.
Hong Jin Lee, Andrew Wislocki, Catherine Goodman, Yan Ji, Rongrong Ge, Hubert Maehr

Mol Pharmacol· June 2006

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Calcitriol derivatives with two different side chains at C-20. II. Diastereoselective syntheses of the metabolically produced 24(R)-hydroxygemini.
Hubert Maehr, Milan R Uskokovic, Luciano Adorini, G Satyanarayana Reddy

J Med Chem· December 2004

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Calcitriol derivatives with two different side chains at C-20. 24-hydroxy derivatives as metabolic products and molecular probes for VDR exploration.
Hubert Maehr, Milan R Uskokovic, G Satyanarayana Reddy, Luciano Adorini

J Steroid Biochem Mol Biol· May 2004

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