Publications by authors named "Hubert Thole"

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Lysine 268 adjacent to transmembrane helix 5 of hamster P-glycoprotein is the major photobinding site of iodomycin in CHO B30 cells.
Annette Demmer, Hubert Thole, Manfred Raida, Burkhard Tümmler

FEBS Open Bio· April 2021

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Synthesis and investigation of the anticancer effects of estrone-16-oxime ethers in vitro.
Ágnes Berényi, Renáta Minorics, Zoltán Iványi, Imre Ocsovszki, Eszter Ducza, Hubert Thole

Steroids· January 2013

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Novel estrogen-related genes and potential biomarkers of ovarian endometriosis identified by differential expression analysis.
Katja Vouk, Tina Smuc, Christina Guggenberger, Martina Ribič-Pucelj, Jasna Sinkovec, Hubert Thole

J Steroid Biochem Mol Biol· July 2011

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Species used for drug testing reveal different inhibition susceptibility for 17beta-hydroxysteroid dehydrogenase type 1.
Gabriele Möller, Bettina Husen, Dorota Kowalik, Leena Hirvelä, Dariusz Plewczynski, Hubert Thole

PLoS One· June 2010

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Ligand-based NMR spectra demonstrate an additional phytoestrogen binding site for 17beta-hydroxysteroid dehydrogenase type 1.
Paul J A Michiels, Christian Ludwig, Michel Stephan, Christina Fischer, Gabriele Möller, Hubert Thole

J Steroid Biochem Mol Biol· November 2009

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Disturbed estrogen and progesterone action in ovarian endometriosis.
Tina Smuc, Neli Hevir, Martina Ribic-Pucelj, Bettina Husen, Hubert Thole

Mol Cell Endocrinol· March 2009

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Structure-activity study in the class of 6-(3'-hydroxyphenyl)naphthalenes leading to an optimization of a pharmacophore model for 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitors.
Sandrine Marchais-Oberwinkler, Martin Frotscher, Erika Ziegler, Ruth Werth, Patricia Kruchten, Hubert Thole

Mol Cell Endocrinol· March 2009

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Estrone C15 derivatives--a new class of 17beta-hydroxysteroid dehydrogenase type 1 inhibitors.
Josef Messinger, Bettina Husen, Pasi Koskimies, Leena Hirvelä, Lila Kallio, Hubert Thole

Mol Cell Endocrinol· March 2009

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In vivo mouse model for analysis of hydroxysteroid (17beta) dehydrogenase 1 inhibitors.
Tarja Lamminen, Taija Saloniemi, Kaisa Huhtinen, Pasi Koskimies, Josef Messinger, Hubert Thole

Mol Cell Endocrinol· March 2009

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Substituted 6-phenyl-2-naphthols. Potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1): design, synthesis, biological evaluation, and pharmacokinetics.
Sandrine Marchais-Oberwinkler, Patricia Kruchten, Martin Frotscher, Erika Ziegler, Alexander Neugebauer, Hubert Thole

J Med Chem· August 2008

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Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases.
Martin Frotscher, Erika Ziegler, Sandrine Marchais-Oberwinkler, Patricia Kruchten, Alexander Neugebauer, Hubert Thole

J Med Chem· April 2008

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Expression and regulation of estrogen-converting enzymes in ectopic human endometrial tissue.
Sabine Fechner, Bettina Husen, Hubert Thole, Markus Schmidt, Isabella Gashaw

Fertil Steril· October 2007

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Purification and characterisation of a jacalin-related, coleoptile specific lectin from Hordeum vulgare.
Ingo Grunwald, Ines Heinig, Hubert H Thole, Dieter Neumann, Uwe Kahmann

Planta· June 2007

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Expression analysis of the genes involved in estradiol and progesterone action in human ovarian endometriosis.
Tina Smuc, Martina Ribic Pucelj, Jasna Sinkovec, Bettina Husen, Hubert Thole

Gynecol Endocrinol· February 2007

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Human hydroxysteroid (17-beta) dehydrogenase 1 expression enhances estrogen sensitivity of MCF-7 breast cancer cell xenografts.
Bettina Husen, Kaisa Huhtinen, Taija Saloniemi, Josef Messinger, Hubert H Thole

Endocrinology· November 2006

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New inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.
Josef Messinger, Leena Hirvelä, Bettina Husen, Lauri Kangas, Pasi Koskimies, Hubert Thole

Mol Cell Endocrinol· March 2006

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Caspase-dependent regulation and subcellular redistribution of the transcriptional modulator YY1 during apoptosis.
Anja Krippner-Heidenreich, Gesa Walsemann, Maroun J Beyrouthy, Stefanie Speckgens, Regine Kraft, Hubert Thole

Mol Cell Biol· May 2005

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Dydrogesterone (Duphaston) and its 20-dihydro-derivative as selective estrogen enzyme modulators in human breast cancer cell lines. Effect on sulfatase and on 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activity.
Gérard Samuel Chetrite, Hubert H Thole, Jean-Claude Philippe, Jorge Raul Pasqualini

Anticancer Res· September 2004

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Phosphatidylcholine metabolism of rat trachea in relation to lung parenchyma and surfactant.
Gunnar A Rau, Heike Dombrowsky, Andreas Gebert, Hubert H Thole, Horst von der Hardt

J Appl Physiol (1985)· September 2003

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Occurrence of estrogen receptor alpha in bovine placentomes throughout mid and late gestation and at parturition.
Gerhard Schuler, Christina Wirth, Ursula Teichmann, Klaus Failing, Rudolf Leiser, Hubert Thole

Biol Reprod· April 2002

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Purification and characterization of the thyrotropin-releasing hormone (TRH)-degrading serum enzyme and its identification as a product of liver origin.
Stephanie Schmitmeier, Hubert Thole, Augustinus Bader, Karl Bauer

Eur J Biochem· February 2002

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