Publications by authors named "Hugo De Jonge"

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Engineering anti-c-MET scFv-conjugated PLGA nanoparticles for precision verteporfin delivery in lung cancer cells: a formulation study.
Alessia Giglio, Enrica Chiesa, Luisa Iamele, Davide Rubes, Massimo Serra, Hugo de Jonge

Int J Pharm· October 2025

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Extrusion of BMP2+ surface colonocytes promotes stromal remodeling and tissue regeneration.
Julian Heuberger, Lichao Liu, Hilmar Berger, Joop van den Heuvel, Manqiang Lin, Hugo de Jonge

Nat Commun· May 2025

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Partially differentiated ileal and distal-colonic human F508del-cystic fibrosis-enteroids secrete fluid in response to forskolin and linaclotide.
Yan Rong, Zixin Zhang, Hugo R de Jonge, Ruxian Lin, Huimin Yu

iScience· May 2025

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Partially differentiated enterocytes in ileal and distal-colonic human F508del-CF-enteroids secrete fluid in response to forskolin and linaclotide.
Yan Rong, Zixin Zhang, Hugo R de Jonge, Ruxian Lin, Huimin Yu

bioRxiv· February 2025

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PD-L1 and IFN-γ modulate Non-Small Cell Lung Cancer (NSCLC) cell plasticity associated to immune checkpoint inhibitor (ICI)-mediated hyperprogressive disease (HPD).
Stefania Angelicola, Francesca Giunchi, Francesca Ruzzi, Mariateresa Frascino, Mary Pitzalis, Hugo De Jonge

J Transl Med· January 2025

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Clinical and Preclinical Activity of EGFR Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancer Harboring Class 3 Mutations.
Alessandro Di Federico, Stefania Angelicola, Mariateresa Frascino, Irene Siracusa, Beatrice Bisanti, Hugo De Jonge

JCO Precis Oncol· December 2024

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Single-molecule imaging and molecular dynamics simulations reveal early activation of the MET receptor in cells.
Yunqing Li, Serena M Arghittu, Marina S Dietz, Gabriel J Hella, Daniel Haße, Hugo de Jonge

Nat Commun· November 2024

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Peptides inhibiting the assembly of monomeric human l-lactate dehydrogenase into catalytically active homotetramer decrease the synthesis of lactate in cultured cells.
Alessandra Stefan, Luca Gentilucci, Francesca Ruffolo, Valentina Rossi, Sofia Sordi, Hugo de Jonge

Protein Sci· October 2024

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CFTR function is impaired in a subset of patients with pancreatitis carrying rare CFTR variants.
Dora Angyal, Karina Kleinfelder, Fabiana Ciciriello, Tessa A Groeneweg, Giulia De Marchi, Hugo R de Jonge

Pancreatology· May 2024

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Pro-inflammatory cytokines stimulate CFTR-dependent anion secretion in pancreatic ductal epithelium.
Dora Angyal, Tessa A Groeneweg, Anny Leung, Max Desain, Kalyan Dulla, Hugo R de Jonge

Cell Mol Biol Lett· January 2024

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Side-by-Side Comparison of uPAR-Targeting Optical Imaging Antibodies and Antibody Fragments for Fluorescence-Guided Surgery of Solid Tumors.
Victor M Baart, Labrinus van Manen, Shadhvi S Bhairosingh, Floris A Vuijk, Luisa Iamele, Hugo de Jonge

Mol Imaging Biol· February 2023

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Modeling bile duct ischemia and reoxygenation injury in human cholangiocyte organoids for screening of novel cholangio-protective agents.
Shaojun Shi, Henk P Roest, Thierry P P van den Bosch, Marcel J C Bijvelds, Markus U Boehnert, Jeroen de Jonge, Hugo R de Jonge

EBioMedicine· February 2023

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A novel agonist for the HGF receptor MET promotes differentiation of human pluripotent stem cells into hepatocyte-like cells.
Yannick Tauran, Myriam Lereau-Bernier, Bertrand David Segard, Mathieu Danoy, Keiichi Kimura, Hugo de Jonge

Dev Growth Differ· December 2022

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Dimerization of kringle 1 domain from hepatocyte growth factor/scatter factor provides a potent MET receptor agonist.
Giovanni de Nola, Bérénice Leclercq, Alexandra Mougel, Solenne Taront, Claire Simonneau, Hugo de Jonge

Life Sci Alliance· July 2022

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Rescue of chloride and bicarbonate transport by elexacaftor-ivacaftor-tezacaftor in organoid-derived CF intestinal and cholangiocyte monolayers.
Marcel J C Bijvelds, Floris J M Roos, Kelly F Meijsen, Henk P Roest, Monique M A Verstegen, Hugo R de Jonge

J Cyst Fibros· May 2022

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Alterations of mucosa-attached microbiome and epithelial cell numbers in the cystic fibrosis small intestine with implications for intestinal disease.
Jennifer Kelly, Miran Al-Rammahi, Kristian Daly, Paul K Flanagan, Arun Urs, Hugo R de Jonge

Sci Rep· April 2022

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Theratyping of the Rare CFTR Variants E193K and R334W in Rectal Organoid-Derived Epithelial Monolayers.
Fabiana Ciciriello, Marcel J C Bijvelds, Federico Alghisi, Kelly F Meijsen, Luca Cristiani, Hugo R De Jonge

J Pers Med· April 2022

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Bicarbonate Transport in Cystic Fibrosis and Pancreatitis.
Dora Angyal, Marcel J C Bijvelds, Marco J Bruno, Maikel P Peppelenbosch, Hugo R de Jonge

Cells· December 2021

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LANCL1 binds abscisic acid and stimulates glucose transport and mitochondrial respiration in muscle cells via the AMPK/PGC-1α/Sirt1 pathway.
Sonia Spinelli, Giulia Begani, Lucrezia Guida, Mirko Magnone, Denise Galante, Hugo De Jonge

Mol Metab· November 2021

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A Potential Treatment of Congenital Sodium Diarrhea in Patients With Activating GUCY2C Mutations.
Anke H M van Vugt, Marcel J C Bijvelds, Hugo R de Jonge, Kelly F Meijsen, Tanja Restin

Clin Transl Gastroenterol· November 2021

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Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers.
Claudia Duranti, Jessica Iorio, Tiziano Lottini, Elena Lastraioli, Silvia Crescioli, Hugo De Jonge

Mol Cancer Ther· August 2021

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Uridine attenuates obesity, ameliorates hepatic lipid accumulation and modifies the gut microbiota composition in mice fed with a high-fat diet.
Yilin Liu, Chunyan Xie, Zhenya Zhai, Ze-Yuan Deng, Hugo R De Jonge

Food Funct· March 2021

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A multimodal molecular imaging approach targeting urokinase plasminogen activator receptor for the diagnosis, resection and surveillance of urothelial cell carcinoma.
Victor M Baart, Geertje van der Horst, Marion M Deken, Shadhvi S Bhairosingh, Timo Schomann, Hugo de Jonge

Eur J Cancer· March 2021

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Anti-Cancer Auto-Antibodies: Roles, Applications and Open Issues.
Hugo de Jonge, Luisa Iamele, Maristella Maggi, Greta Pessino, Claudia Scotti

Cancers (Basel)· February 2021

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Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease.
Monique M A Verstegen, Floris J M Roos, Ksenia Burka, Helmuth Gehart, Myrthe Jager, Hugo R de Jonge, Jeroen de Jonge

Sci Rep· December 2020

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