Publications by authors named "Hugo Horlings"

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Fasting boosts breast cancer therapy efficacy via glucocorticoid activation.
Nuno Padrão, Tesa M Severson, Sebastian Gregoricchio, Ana Guijarro, Catrin Lutz, Hugo Horlings

Nature· December 2025

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Performance Assessment of a Deep Learning-based Algorithm for Ovarian Cancer Histotyping in an Independent Data Set.
Hein S Zelisse, Maryam Asadi-Aghbolaghi, Hossein Farahani, Malou L H Snijders, Gerrit K J Hooijer, Hugo M Horlings

Am J Surg Pathol· November 2025

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Label-efficient computational tumour infiltrating lymphocyte assessment in breast cancer (ECTIL): multicentre validation in 2340 patients with breast cancer.
Yoni Schirris, Rosie Voorthuis, Mark Opdam, Marte Liefaard, Gabe S Sonke, Hugo M Horlings

Lancet Digit Health· November 2025

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Beyond BRCA deficiency: Clinical and molecular predictors of survival in patients with BRCA-deficient tubo-ovarian high-grade serous carcinoma.
Dale Garsed, Tibor Zwimpfer, Sian Fereday, Ahwan Pandey, Dinuka Ariyaratne, Hugo Horlings

Res Sq· October 2025

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Beyond deficiency: Clinical and molecular predictors of survival in patients with -deficient tubo-ovarian high-grade serous carcinoma.
Tibor A Zwimpfer, Sian Fereday, Ahwan Pandey, Dinuka Ariyaratne, Madawa W Jayawardana, Hugo M Horlings

medRxiv· September 2025

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H&E to IHC virtual staining methods in breast cancer: an overview and benchmarking.
Pascal Klöckner, José Teixeira, Diana Montezuma, João Fraga, Hugo M Horlings

NPJ Digit Med· July 2025

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Evaluation of the recently established Dutch nationwide Archipelago of Ovarian Cancer Research biobank.
Hein S Zelisse, Mignon D J M van Gent, Constantijne H Mom, Sander de Ridder, Malou L H Snijders, Hugo M Horlings

Ann Diagn Pathol· February 2025

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Temporal and spatial composition of the tumor microenvironment predicts response to immune checkpoint inhibition.
Noah F Greenwald, Iris Nederlof, Cameron Sowers, Daisy Yi Ding, Seongyeol Park, Hugo M Horlings

bioRxiv· January 2025

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The Information Technology (IT) Infrastructure of the Multicenter Archipelago of Ovarian Cancer Research Biobank: A Potential Blueprint for Other Biobanks.
Hein S Zelisse, Sander de Ridder, Mignon D J M van Gent, Constantijne H Mom, G Bea A Wisman, Hugo M Horlings

Biopreserv Biobank· December 2024

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Neoadjuvant nivolumab or nivolumab plus ipilimumab in early-stage triple-negative breast cancer: a phase 2 adaptive trial.
Iris Nederlof, Olga I Isaeva, Manon de Graaf, Robbert C A M Gielen, Noor A M Bakker, Hugo M Horlings

Nat Med· November 2024

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An explainable longitudinal multi-modal fusion model for predicting neoadjuvant therapy response in women with breast cancer.
Yuan Gao, Sofia Ventura-Diaz, Xin Wang, Muzhen He, Zeyan Xu, Hugo M Horlings

Nat Commun· November 2024

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Does "One Size Fits All"? Rethinking FIGO Depth of Invasion Measurements in Vulvar Cancer.
Maaike C G Bleeker, Tjalling Bosse, Koen K van de Vijver, Joost Bart, Hugo Horlings

Int J Gynecol Pathol· September 2024

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High expression of phosphoglycerate dehydrogenase predicts poor outcome in patients with high-grade serous ovarian cancer.
Lilian van Wagensveld, Tom Van Nyen, Daniela Annibali, Gabe S Sonke, Roy F P M Kruitwagen, Hugo M Horlings

Oncologist· September 2024

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Tumour microenvironment characterisation to stratify patients for hyperthermic intraperitoneal chemotherapy in high-grade serous ovarian cancer (OVHIPEC-1).
S Lot Aronson, Cédric Walker, Bram Thijssen, Koen K van de Vijver, Hugo M Horlings

Br J Cancer· August 2024

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Tumor-Infiltrating Lymphocytes in Patients With Stage I Triple-Negative Breast Cancer Untreated With Chemotherapy.
Veerle C M Geurts, Sara Balduzzi, Tessa G Steenbruggen, Sabine C Linn, Sabine Siesling, Hugo M Horlings

JAMA Oncol· August 2024

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Predictive gene expression profile for adjuvant taxane benefit in breast cancer in the MATADOR trial.
Mark Opdam, Annelot G J van Rossum, Marlous Hoogstraat, Gergana Bounova, Hugo M Horlings

iScience· August 2024

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PatchSorter: a high throughput deep learning digital pathology tool for object labeling.
Cédric Walker, Tasneem Talawalla, Robert Toth, Akhil Ambekar, Kien Rea, Hugo Mark Horlings

NPJ Digit Med· June 2024

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Evaluating the effectiveness of pre-operative diagnosis of ovarian cancer using minimally invasive liquid biopsies by combining serum human epididymis protein 4 and cell-free DNA in patients with an ovarian mass.
Duco H K Gaillard, Pien Lof, Erik A Sistermans, Tom Mokveld, Hugo Mark Horlings

Int J Gynecol Cancer· May 2024

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Image-based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast Cancer.
Chowdhury Arif Jahangir, David B Page, Glenn Broeckx, Claudia A Gonzalez, Caoimbhe Burke, Hugo M Horlings

J Pathol· March 2024

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PROACTING: predicting pathological complete response to neoadjuvant chemotherapy in breast cancer from routine diagnostic histopathology biopsies with deep learning.
Witali Aswolinskiy, Enrico Munari, Hugo M Horlings, Lennart Mulder, Giuseppe Bogina

Breast Cancer Res· November 2023

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The prognostic value of tumor-stroma ratio and a newly developed computer-aided quantitative analysis of routine H&E slides in high-grade serous ovarian cancer.
Lilian van Wagensveld, Cedric Walker, Kerstin Hahn, Joyce Sanders, Roy Kruitwagen, Hugo Horlings

Res Sq· November 2023

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CMTM6 shapes antitumor T cell response through modulating protein expression of CD58 and PD-L1.
Beiping Miao, Zhaoqing Hu, Riccardo Mezzadra, Lotte Hoeijmakers, Astrid Fauster, Hugo M Horlings

Cancer Cell· October 2023

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B-cells and regulatory T-cells in the microenvironment of HER2+ breast cancer are associated with decreased survival: a real-world analysis of women with HER2+ metastatic breast cancer.
Tessa G Steenbruggen, Denise M Wolf, Michael J Campbell, Joyce Sanders, Sten Cornelissen, Hugo M Horlings

Breast Cancer Res· October 2023

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Characterization of the Tumor Microenvironment of De Novo Oligometastatic Breast Cancer in a Nationwide Cohort.
Tessa G Steenbruggen, Denise M Wolf, Bram Thijssen, Joyce Sanders, Sten Cornelissen, Hugo M Horlings

JCO Precis Oncol· September 2023

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Pitfalls in machine learning-based assessment of tumor-infiltrating lymphocytes in breast cancer: A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer.
Jeppe Thagaard, Glenn Broeckx, David B Page, Chowdhury Arif Jahangir, Sara Verbandt, Hugo M Horlings

J Pathol· August 2023

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