Publications by authors named "Hugo Sepulveda"

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High interferon response signatures in SLE patient leukocytes are associated with increased transposable element expression in gene introns and intergenic regions.
Leo J Arteaga-Vazquez, Hugo Sepulveda, Bruno Villalobos Reveles, Kazumasa Suzuki, Kenneth C Kalunian

Mob DNA· November 2025

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Returning home: building a scientific future in Chile.
Hugo Sepulveda

Nat Struct Mol Biol· October 2025

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Loss of TET function in T regulatory cells yields ex-Treg cells biased toward T follicular helper cells, causing autoimmune diseases through autoantibody production.
Kazumasa Suzuki, Leo J Arteaga-Vazquez, Bruno Villalobos Reveles, Lot Hernández-Espinosa, Isaac F López-Moyado, Hugo Sepulveda

bioRxiv· September 2025

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Distinct interferon response patterns link to increased transposable element expression in leukocytes of systemic lupus erythematosus patients.
Leo J Arteaga-Vazquez, Hugo Sepulveda, Bruno Villalobos Reveles, Kazumasa Suzuki, Kenneth C Kalunian

bioRxiv· August 2025

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OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide.
Hugo Sepulveda, Xiang Li, Leo J Arteaga-Vazquez, Isaac F López-Moyado, Melina Brunelli

Nat Struct Mol Biol· July 2025

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A mutant ASXL1-BAP1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia.
Zhen Dong, Hugo Sepulveda, Leo J Arteaga-Vazquez, Chad Blouin, Jenna Fernandez

Proc Natl Acad Sci U S A· January 2025

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A mutant ASXL1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia.
Zhen Dong, Hugo Sepulveda, Leo J Arteaga-Vazquez, Chad Blouin, Jenna Fernandez

bioRxiv· January 2025

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The Role of Fatty Acid Synthase in the Vascular Smooth Muscle Cell to Foam Cell Transition.
Bethany J Bogan, Holly C Williams, Claire M Holden, Vraj Patel, Giji Joseph, Hugo Sepulveda

Cells· April 2024

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OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide.
Hugo Sepulveda, Xiang Li, Xiaojing Yue, J Carlos Angel, Leo J Arteaga-Vazquez

bioRxiv· January 2024

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OGT controls mammalian cell viability by regulating the proteasome/mTOR/ mitochondrial axis.
Xiang Li, Xiaojing Yue, Hugo Sepulveda, Rajan A Burt, David A Scott

Proc Natl Acad Sci U S A· January 2023

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Acute deletion of TET enzymes results in aneuploidy in mouse embryonic stem cells through decreased expression of Khdc3.
Romain O Georges, Hugo Sepulveda, J Carlos Angel, Eric Johnson, Susan Palomino

Nat Commun· October 2022

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The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells.
Solange Rivas, Patricio Silva, Montserrat Reyes, Hugo Sepúlveda, Luis Solano

Sci Rep· December 2020

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Ski Is Required for Tri-Methylation of H3K9 in Major Satellite and for Repression of Pericentromeric Genes: Mmp3, Mmp10 and Mmp13, in Mouse Fibroblasts.
Claudio Cappelli, Hugo Sepulveda, Solange Rivas, Víctor Pola, Ulises Urzúa

J Mol Biol· May 2020

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Mll-COMPASS complexes mediate H3K4me3 enrichment and transcription of the osteoblast master gene Runx2/p57 in osteoblasts.
Adriana Rojas, Hugo Sepulveda, Berta Henriquez, Rodrigo Aguilar, Tatiana Opazo

J Cell Physiol· May 2019

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Expression of the ectodomain-releasing protease ADAM17 is directly regulated by the osteosarcoma and bone-related transcription factor RUNX2.
Héctor F Araya, Hugo Sepulveda, Carlos O Lizama, Oscar A Vega, Sofia Jerez

J Cell Biochem· November 2018

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Variable transcriptional responsiveness of the P2X3 receptor gene during CFA-induced inflammatory hyperalgesia.
Paulina Nuñez-Badinez, Hugo Sepúlveda, Emilio Diaz, Wolfgang Greffrath, Rolf-Detlef Treede

J Cell Biochem· May 2018

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Runt-Related Transcription Factor 2 Induction During Differentiation of Wharton's Jelly Mesenchymal Stem Cells to Osteoblasts Is Regulated by Jumonji AT-Rich Interactive Domain 1B Histone Demethylase.
Francisco Bustos, Hugo Sepúlveda, Catalina P Prieto, Margarita Carrasco, Lorena Díaz

Stem Cells· December 2017

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Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells.
Natalia I Díaz-Valdivia, Claudia C Calderón, Jorge E Díaz, Lorena Lobos-González, Hugo Sepulveda

Oncotarget· December 2017

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Tet-Mediated DNA Demethylation Is Required for SWI/SNF-Dependent Chromatin Remodeling and Histone-Modifying Activities That Trigger Expression of the Sp7 Osteoblast Master Gene during Mesenchymal Lineage Commitment.
Hugo Sepulveda, Alejandro Villagra, Martin Montecino

Mol Cell Biol· October 2017

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Epigenetic Signatures at the RUNX2-P1 and Sp7 Gene Promoters Control Osteogenic Lineage Commitment of Umbilical Cord-Derived Mesenchymal Stem Cells.
Hugo Sepulveda, Rodrigo Aguilar, Catalina P Prieto, Francisco Bustos, Sócrates Aedo

J Cell Physiol· September 2017

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A functional IL1RL1 variant regulates corticosteroid-induced sST2 expression in ulcerative colitis.
David Díaz-Jiménez, Lucía Núñez, Marjorie De la Fuente, Karen Dubois-Camacho, Hugo Sepúlveda

Sci Rep· August 2017

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Mitotic Inheritance of mRNA Facilitates Translational Activation of the Osteogenic-Lineage Commitment Factor Runx2 in Progeny of Osteoblastic Cells.
Nelson Varela, Alejandra Aranguiz, Carlos Lizama, Hugo Sepulveda, Marcelo Antonelli

J Cell Physiol· May 2016

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Prenatal stress down-regulates Reelin expression by methylation of its promoter and induces adult behavioral impairments in rats.
Ismael Palacios-García, Ariel Lara-Vásquez, Juan F Montiel, Gabriela F Díaz-Véliz, Hugo Sepúlveda

PLoS One· April 2016

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The Specification of Cortical Subcerebral Projection Neurons Depends on the Direct Repression of TBR1 by CTIP1/BCL11a.
José Cánovas, F Andrés Berndt, Hugo Sepúlveda, Rodrigo Aguilar, Felipe A Veloso

J Neurosci· May 2015

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A functional N-terminal domain in C/EBPβ-LAP* is required for interacting with SWI/SNF and to repress Ric-8B gene transcription in osteoblasts.
Rodrigo Aguilar, Rodrigo Grandy, Daniel Meza, Hugo Sepulveda, Philippe Pihan

J Cell Physiol· October 2014

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