Publications by authors named "Hui-Lei Yu"

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D
Designing an oxidase toolbox for site-directed oxidation of taxanes.
Mingyuan Lai, Yu Weng, Jian Wei, Xin-Yi Lu, Zhengyu Huang, Hui-Lei Yu

Nat Commun· December 2025

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Flipping of a Non-productive Substrate Binding Conformation Facilitates Hydroxynitrile Lyase Catalyzed Hydrocyanation.
Yu-Cong Zheng, Yong Mao, Qiang Geng, Fu-Long Li, Xu-Dong Kong, Hui-Lei Yu

Angew Chem Int Ed Engl· October 2025

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Computation-driven redesign of an NRPS-like carboxylic acid reductase improves activity and selectivity.
Kun Shi, Ju-Mou Li, Mu-Qiang Wang, Yi-Ke Zhang, Zhi-Jun Zhang, Hui-Lei Yu

Sci Adv· November 2024

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Enhancing the expression of terminal deoxynucleotidyl transferases by N-terminal truncation.
An-Na Li, Kun Shi, Bu-Bing Zeng, Jian-He Xu, Hui-Lei Yu

Biotechnol J· September 2024

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Facilitating secretory expression of apple seed β-glucosidase in Komagataella phaffii for the efficient preparation of salidroside.
Xin-Yi Lu, Ming-Yuan Lai, Peng Qin, Yu-Cong Zheng, Jia-Yi Liao, Hui-Lei Yu

Biotechnol J· August 2024

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Directed evolution of Baeyer-Villiger monooxygenase for highly secretory expressed in Pichia pastoris and efficient preparation of chiral pyrazole sulfoxide.
Peng Qin, Xin-Yi Lu, Jian-He Xu, Hui-Lei Yu

Biotechnol Bioeng· March 2024

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Development of a Thermodynamically Favorable Multi-enzyme Cascade Reaction for Efficient Sustainable Production of ω-Amino Fatty Acids and α,ω-Diamines.
Ju-Mou Li, Kun Shi, Ai-Tao Li, Zhi-Jun Zhang, Hui-Lei Yu

ChemSusChem· March 2024

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D
Development of a Thermodynamically Favorable Multi-enzyme Cascade Reaction for Efficient Sustainable Production of ω-Amino Fatty Acids and α,ω-Diamines.
Ju-Mou Li, Kun Shi, Ai-Tao Li, Zhi-Jun Zhang, Hui-Lei Yu

ChemSusChem· March 2024

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Improving the Enantioselectivity of CHMO for Asymmetric Synthesis of Podophyllotoxin Precursor.
Shou-Cheng Huang, Yi-Ke Zhang, Qiang Geng, Qi-Kang Huang, Jian-He Xu, Hui-Lei Yu

Chembiochem· December 2023

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Enzymatic synthesis of pharmacologically relevant chiral sulfoxides by improved BVMO variants.
Chen Zhao, Feng Liu, Min Zhou, Qiang Geng, Hui-Lei Yu

Chem Commun (Camb)· December 2023

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Rational Design of Taxadiene Hydroxylase by Ancestral Enzyme Construction and the Elucidation of Key Amino Acids.
Zihan Zhang, Longhao Huang, Zhi-Jun Zhang, Jian-He Xu, Hui-Lei Yu

Biochemistry· November 2023

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Engineering a Formate Dehydrogenase for NADPH Regeneration.
Wei Ma, Qiang Geng, Cheng Chen, Yu-Cong Zheng, Hui-Lei Yu

Chembiochem· October 2023

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Prokaryotic expression and characterization of artificial self-sufficient CYP120A monooxygenases.
Ru-Yi Ye, Juan Song, Zhi-Jun Zhang, Hui-Lei Yu

Appl Microbiol Biotechnol· September 2023

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Virtual screening of carboxylic acid reductases for biocatalytic synthesis of 6-aminocaproic acid and 1,6-hexamethylenediamine.
Kun Shi, Ju-Mou Li, Zhi-Jun Zhang, Qi Chen, Jian-He Xu, Hui-Lei Yu

Biotechnol Bioeng· July 2023

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Hydroxylases involved in terpenoid biosynthesis: a review.
Zihan Zhang, Qing-Yang Wu, Yue Ge, Zheng-Yu Huang, Ran Hong, Hui-Lei Yu

Bioresour Bioprocess· July 2023

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Colorimetric High-Throughput Screening Method for Directed Evolution of Prazole Sulfide Monooxygenase.
Feng Liu, Qiang Geng, Chen Zhao, Shi-Miao Ren, Hui-Lei Yu

Chembiochem· August 2022

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Construction of an Escherichia coli cell factory to synthesize taxadien-5α-ol, the key precursor of anti-cancer drug paclitaxel.
Qing-Yang Wu, Zheng-Yu Huang, Jin-Yi Wang, Hui-Lei Yu, Jian-He Xu

Bioresour Bioprocess· August 2022

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Facile Production of (+)-Aristolochene and (+)-Bicyclogermacrene in Using Newly Discovered Sesquiterpene Synthases from .
Zheng-Yu Huang, Qing-Yang Wu, Chun-Xiu Li, Hui-Lei Yu, Jian-He Xu

J Agric Food Chem· May 2022

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Secretory expression of cyclohexanone monooxygenase by methylotrophic yeast for efficient omeprazole sulfide bio-oxidation.
Ya-Jing Li, Yu-Cong Zheng, Qiang Geng, Feng Liu, Zhi-Jun Zhang, Hui-Lei Yu

Bioresour Bioprocess· August 2021

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Mining methods and typical structural mechanisms of terpene cyclases.
Zheng-Yu Huang, Ru-Yi Ye, Hui-Lei Yu, Ai-Tao Li, Jian-He Xu

Bioresour Bioprocess· July 2021

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A High-Throughput Screening Method for the Directed Evolution of Hydroxynitrile Lyase towards Cyanohydrin Synthesis.
Yu-Cong Zheng, Liang-Yi Ding, Qiao Jia, Zuming Lin, Ran Hong, Hui-Lei Yu

Chembiochem· March 2021

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Identification two key residues at the intersection of domains of a thioether monooxygenase for improving its sulfoxidation performance.
Shi-Miao Ren, Feng Liu, Yin-Qi Wu, Qi Chen, Zhi-Jun Zhang, Hui-Lei Yu

Biotechnol Bioeng· February 2021

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Engineering Bacillus subtilis Isoleucine Dioxygenase for Efficient Synthesis of (2,3,4)-4-Hydroxyisoleucine.
Ping Du, Shuai Yan, Xiao-Long Qian, Jiang Pan, Zhi-Jun Zhang, Hui-Lei Yu

J Agric Food Chem· December 2020

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One-pot biocatalytic route from cycloalkanes to α,ω-dicarboxylic acids by designed Escherichia coli consortia.
Fei Wang, Jing Zhao, Qian Li, Jun Yang, Renjie Li, Xiaojuan Yu, Hui-Lei Yu

Nat Commun· October 2020

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Attenuated substrate inhibition of a haloketone reductase via structure-guided loop engineering.
Yue-Peng Shang, Qi Chen, Ai-Tao Li, Shu Quan, Jian-He Xu, Hui-Lei Yu

J Biotechnol· January 2020

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