Publications by authors named "Ian A Simpson"

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Apo- and holo-transferrin differentially interact with hephaestin and ferroportin in a novel mechanism of cellular iron release regulation.
Stephanie L Baringer, Kondaiah Palsa, Vladimir S Spiegelman, Ian A Simpson, James R Connor

J Biomed Sci· June 2023

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Embracing Scientific Debate in Brain Metabolism.
Jens V Andersen, Blanca I Aldana, Lasse K Bak, Kevin L Behar, Karin Borges, Ian A Simpson

J Neurochem· September 2025

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Brain iron acquisition depends on age and sex in iron-deficient mice.
Kondaiah Palsa, Elizabeth B Neely, Stephanie L Baringer, Timothy B Helmuth, Ian A Simpson

FASEB J· January 2024

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Amyloid-β exposed astrocytes induce iron transport from endothelial cells at the blood-brain barrier by altering the ratio of apo- and holo-transferrin.
Stephanie L Baringer, Avraham S Lukacher, Kondaiah Palsa, Hyosung Kim, Ethan S Lippmann, Ian A Simpson

J Neurochem· October 2023

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Brain iron acquisition: An overview of homeostatic regulation and disease dysregulation.
Stephanie L Baringer, Ian A Simpson, James R Connor

J Neurochem· June 2023

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Amyloid-β exposed astrocytes induce iron transport from endothelial cells at the blood-brain barrier by altering the ratio of apo- and holo-transferrin.
Stephanie L Baringer, Avraham S Lukacher, Kondaiah Palsa, Hyosung Kim, Ethan S Lippmann, Ian A Simpson

bioRxiv· May 2023

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Exosomes are involved in iron transport from human blood-brain barrier endothelial cells and are modified by endothelial cell iron status.
Kondaiah Palsa, Stephanie L Baringer, Ganesh Shenoy, Vladimir S Spiegelman, Ian A Simpson

J Biol Chem· February 2023

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Apo- and holo- transferrin differentially interact with ferroportin and hephaestin to regulate iron release at the blood-brain barrier.
Stephanie Baringer, Kondaiah Palsa, Ian A Simpson, James R Connor

Res Sq· January 2023

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Apo- and holo- transferrin differentially interact with ferroportin and hephaestin to regulate iron release at the blood-brain barrier.
Stephanie L Baringer, Kondaiah Palsa, Ian A Simpson, James R Connor

bioRxiv· January 2023

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The effect of chronic exposure to metformin in a new type-2 diabetic NONcNZO10/LtJ mouse model of stroke.
Rashmi Kumari, Lisa Willing, Scot R Kimball, Ian A Simpson

Pharmacol Rep· August 2022

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Regulation of brain iron uptake by apo- and holo-transferrin is dependent on sex and delivery protein.
Stephanie L Baringer, Elizabeth B Neely, Kondaiah Palsa, Ian A Simpson, James R Connor

Fluids Barriers CNS· June 2022

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The role of neutrophils in mediating stroke injury in the diabetic db/db mouse brain following hypoxia-ischemia.
Rashmi Kumari, Kerstin Bettermann, Lisa Willing, Kusum Sinha, Ian A Simpson

Neurochem Int· October 2020

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Evidence for communication of peripheral iron status to cerebrospinal fluid: clinical implications for therapeutic strategy.
James R Connor, Kari Duck, Stephanie Patton, Ian A Simpson, Lynn Marie Trotti

Fluids Barriers CNS· April 2020

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Transferrin and H-ferritin involvement in brain iron acquisition during postnatal development: impact of sex and genotype.
Brian Chiou, Elizabeth B Neely, Dillon S Mcdevitt, Ian A Simpson, James R Connor

J Neurochem· February 2020

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Endothelial cells are critical regulators of iron transport in a model of the human blood-brain barrier.
Brian Chiou, Emma H Neal, Aaron B Bowman, Ethan S Lippmann, Ian A Simpson

J Cereb Blood Flow Metab· November 2019

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Archaeological assessment reveals Earth's early transformation through land use.
Lucas Stephens, Dorian Fuller, Nicole Boivin, Torben Rick, Nicolas Gauthier, Ian A Simpson

Science· August 2019

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Pharmaceutical iron formulations do not cross a model of the human blood-brain barrier.
Brian Chiou, Emma H Neal, Aaron B Bowman, Ethan S Lippmann, Ian A Simpson

PLoS One· January 2019

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A role for sex and a common HFE gene variant in brain iron uptake.
Kari A Duck, Elizabeth B Neely, Ian A Simpson, James R Connor

J Cereb Blood Flow Metab· March 2018

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The role of HFE genotype in macrophage phenotype.
Anne M Nixon, Elizabeth Neely, Ian A Simpson, James R Connor

J Neuroinflammation· February 2018

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Regulatory mechanisms for iron transport across the blood-brain barrier.
Kari A Duck, Ian A Simpson, James R Connor

Biochem Biophys Res Commun· December 2017

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Climate challenges, vulnerabilities, and food security.
Margaret C Nelson, Scott E Ingram, Andrew J Dugmore, Richard Streeter, Matthew A Peeples, Ian A Simpson

Proc Natl Acad Sci U S A· January 2016

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A novel model for brain iron uptake: introducing the concept of regulation.
Ian A Simpson, Padmavathi Ponnuru, Marianne E Klinger, Roland L Myers, Kavi Devraj

J Cereb Blood Flow Metab· January 2015

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GLUT-1 glucose transporters in the blood-brain barrier: differential phosphorylation.
Kavi Devraj, Marianne E Klinger, Roland L Myers, Ashwini Mokashi, Richard A Hawkins, Ian A Simpson

J Neurosci Res· December 2011

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Increased cerebral matrix metalloprotease-9 activity is associated with compromised recovery in the diabetic db/db mouse following a stroke.
Rashmi Kumari, Lisa B Willing, Shyama D Patel, Karen A Baskerville, Ian A Simpson

J Neurochem· December 2011

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REDD1 (regulated in development and DNA damage response 1) expression in skeletal muscle as a surrogate biomarker of the efficiency of glucocorticoid receptor blockade.
Rashmi Kumari, Lisa B Willing, Leonard S Jefferson, Ian A Simpson, Scot R Kimball

Biochem Biophys Res Commun· September 2011

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