Publications by authors named "Ian Sipula"

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Mutation in IR or IGF1R produces features of long-lived mice while maintaining metabolic health.
Ulalume Hernández-Arciga, Jun Kyoung Kim, Jacob L Fisher, Alexander Tyshkovskiy, Alibek Moldakozhayev, Ian J Sipula

JCI Insight· December 2025

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ZC3H4, a novel regulator of mitochondrial complex I, impacts prostate stromal cell senescence, attachment, adhesion and anoikis resistance.
Teresa T Liu, Mia J Carrarini, Livianna K Myklebust, Kegan O Skalitzky, Nathalie El-Khoury, Ian J Sipula

Cell Death Dis· October 2025

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The SET1/COMPASS subunit RBBP5 orchestrates epigenetic control of global proteostasis and the 12h oscillator to safeguard metabolic and cellular homeostasis.
Syeda Kubra, Michelle Sun, William Dion, Ahmet Catak, Hannah Luong, Ian Sipula

bioRxiv· April 2025

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Dietary methionine restriction started late in life promotes healthy aging in a sex-specific manner.
Ulalume Hernández-Arciga, Ceda Stamenkovic, Shweta Yadav, Chiara Nicoletti, Wafaa N Albalawy, Ian J Sipula

Sci Adv· April 2025

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Role of Cardiorespiratory Fitness and Mitochondrial Oxidative Capacity in Reduced Walk Speed of Older Adults With Diabetes.
Sofhia V Ramos, Giovanna Distefano, Li-Yung Lui, Peggy M Cawthon, Philip Kramer, Ian J Sipula

Diabetes· July 2024

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Megalin Knockout Reduces SGLT2 Expression and Sensitizes to Western Diet-induced Kidney Injury.
Elynna B Youm, Katherine E Shipman, Wafaa N Albalawy, Amber M Vandevender, Ian J Sipula

Function (Oxf)· July 2024

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Inhibitory protein-protein interactions of the SIRT1 deacetylase are choreographed by post-translational modification.
Troy C Krzysiak, You-Jin Choi, Yong Joon Kim, Yunhan Yang, Christopher DeHaven, Ian Sipula

Protein Sci· April 2024

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Role of Cardiorespiratory Fitness and Mitochondrial Energetics in Reduced Walk Speed of Older Adults with Diabetes in the Study of Muscle, Mobility and Aging (SOMMA).
Sofhia V Ramos, Giovanna Distefano, Li-Yung Lui, Peggy M Cawthon, Philip Kramer, Ian J Sipula

medRxiv· November 2023

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Mitochondrial Energetics in Skeletal Muscle Are Associated With Leg Power and Cardiorespiratory Fitness in the Study of Muscle, Mobility and Aging.
Theresa Mau, Li-Yung Lui, Giovanna Distefano, Philip A Kramer, Sofhia V Ramos, Ian Sipula

J Gerontol A Biol Sci Med Sci· August 2023

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G-protein coupled receptor 19 (GPR19) knockout mice display sex-dependent metabolic dysfunction.
Bellina A S Mushala, Bingxian Xie, Ian J Sipula, Michael W Stoner, Dharendra Thapa

Sci Rep· April 2023

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Reduced hepatocyte mitophagy is an early feature of NAFLD pathogenesis and hastens the onset of steatosis, inflammation and fibrosis.
Ramya Undamatla, Olayemi G Fagunloye, Jeffrey Chen, Lia R Edmunds, Anjana Murali, Ian Sipula

Res Sq· January 2023

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Hepatocyte-derived GDF15 suppresses feeding and improves insulin sensitivity in obese mice.
Bingxian Xie, Anjana Murali, Amber M Vandevender, Jeffrey Chen, Agustin Gil Silva, Ian Sipula

iScience· December 2022

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Empagliflozin restores cardiac metabolic flexibility in diet-induced obese C57BL6/J mice.
Bingxian Xie, Wesley Ramirez, Amanda M Mills, Brydie R Huckestein, Moira Anderson, Ian Sipula

Curr Res Physiol· May 2022

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Intestinal HIF-2α Regulates GLP-1 Secretion via Lipid Sensing in L-Cells.
Raja Gopal Reddy Mooli, Dhanunjay Mukhi, Anil K Pasupulati, Simon S Evers, Ian J Sipula

Cell Mol Gastroenterol Hepatol· April 2022

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Tregs facilitate obesity and insulin resistance via a Blimp-1/IL-10 axis.
Lisa Y Beppu, Raja Gopal Reddy Mooli, Xiaoyao Qu, Giovanni J Marrero, Christopher A Finley, Ian Sipula

JCI Insight· February 2021

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Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance.
Lia R Edmunds, Bingxian Xie, Amanda M Mills, Brydie R Huckestein, Ramya Undamatla, Ian Sipula

Mol Metab· November 2020

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Petite Integration Factor 1 (PIF1) helicase deficiency increases weight gain in Western diet-fed female mice without increased inflammatory markers or decreased glucose clearance.
Frances R Belmonte, Nikolaos Dedousis, Ian Sipula, Nikita A Desai, Aatur D Singhi

PLoS One· January 2020

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Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities.
Daniel B Harmon, W Kyle Mandler, Ian J Sipula, Nikolaos Dedousis, Sara E Lewis

Diabetes· June 2019

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Adipose tissue-derived free fatty acids initiate myeloid cell accumulation in mouse liver in states of lipid oversupply.
Daniel B Harmon, Chao Wu, Nikolaos Dedousis, Ian J Sipula, Maja Stefanovic-Racic

Am J Physiol Endocrinol Metab· November 2018

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Elevated metabolic rate and skeletal muscle oxidative metabolism contribute to the reduced susceptibility of NF-κB p50 null mice to obesity.
Bankim A Bhatt, Nikolaos Dedousis, Ian J Sipula, Robert M O'Doherty

Physiol Rep· September 2018

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Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice.
Dionysios V Chartoumpekis, Dushani L Palliyaguru, Nobunao Wakabayashi, Marco Fazzari, Nicholas K H Khoo, Ian Sipula

Am J Physiol Endocrinol Metab· August 2018

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Nrf2 prevents Notch-induced insulin resistance and tumorigenesis in mice.
Dionysios V Chartoumpekis, Yoko Yagishita, Marco Fazzari, Dushani L Palliyaguru, Uma Nm Rao, Ian Sipula

JCI Insight· March 2018

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DNA methylation alters transcriptional rates of differentially expressed genes and contributes to pathophysiology in mice fed a high fat diet.
Pili Zhang, Tianjiao Chu, N Dedousis, Benjamin S Mantell, Ian Sipula

Mol Metab· April 2017

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Kupffer cells facilitate the acute effects of leptin on hepatic lipid metabolism.
Anantha Metlakunta, Wan Huang, Maja Stefanovic-Racic, Nikolaos Dedousis, Ian Sipula

Am J Physiol Endocrinol Metab· January 2017

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Abnormal lipid processing but normal long-term repopulation potential of myc-/- hepatocytes.
Lia R Edmunds, P Anthony Otero, Lokendra Sharma, Sonia D'Souza, James M Dolezal, Ian J Sipula

Oncotarget· May 2016

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