Publications by authors named "Ian Zachary"

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Quinoline-Based Neuropilin‑1 Antagonists Exhibit a Pure Antagonist Profile and Block Vascular Endothelial Growth Factor-Induced Pain.
Sara Hestehave, Silvia Dragoni, Philip Fallon, Filipa Mota, Aida Calderon-Rivera, Ian C Zachary

ACS Pharmacol Transl Sci· November 2025

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Maternal PlGF and umbilical Dopplers predict pregnancy outcomes at diagnosis of early-onset fetal growth restriction.
Rebecca Spencer, Kasia Maksym, Kurt Hecher, Karel Maršál, Francesc Figueras, Ian Zachary

J Clin Invest· September 2023

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The E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2D2 regulate VEGFR2 dynamics and endothelial function.
William R Critchley, Gina A Smith, Ian C Zachary, Michael A Harrison, Sreenivasan Ponnambalam

J Cell Sci· May 2023

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Mechanisms of Acquired Resistance to Anti-VEGF Therapy for Neovascular Eye Diseases.
Dhyana Sharma, Ian Zachary, Haiyan Jia

Invest Ophthalmol Vis Sci· May 2023

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Bcar1/p130Cas is essential for ventricular development and neural crest cell remodelling of the cardiac outflow tract.
Marwa Mahmoud, Ian Evans, Laura Wisniewski, Yuen Tam, Claire Walsh, Ian Zachary

Cardiovasc Res· June 2022

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Monitoring VEGF-Stimulated Calcium Ion Flux in Endothelial Cells.
William R Critchley, Gareth W F Fearnley, Izma Abdul-Zani, Carmen Molina-Paris, Claus Bendtsen, Ian C Zachary

Methods Mol Biol· April 2022

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Peptides Derived from Vascular Endothelial Growth Factor B Show Potent Binding to Neuropilin-1.
Filipa Mota, Tamas Yelland, Jennie A Hutton, Jennifer Parker, Anastasia Patsiarika, Ian C Zachary

Chembiochem· January 2022

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Comparison of Efficiency and Function of Vascular Endothelial Growth Factor Adenovirus Vectors in Endothelial Cells for Gene Therapy of Placental Insufficiency.
Carlo Rossi, Mark Lees, Vedanta Mehta, Tommi Heikura, John Martin, Ian Zachary

Hum Gene Ther· November 2020

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Neuropilin 1 mediates epicardial activation and revascularization in the regenerating zebrafish heart.
Vanessa Lowe, Laura Wisniewski, Jacob Sayers, Ian Evans, Paul Frankel, Ian C Zachary

Development· July 2019

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Endothelial C-Type Natriuretic Peptide Is a Critical Regulator of Angiogenesis and Vascular Remodeling.
Kristen J Bubb, Aisah A Aubdool, Amie J Moyes, Sarah Lewis, Jonathan P Drayton, Ian C Zachary

Circulation· March 2019

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Smooth muscle cell-specific knockout of neuropilin-1 impairs postnatal lung development and pathological vascular smooth muscle cell accumulation.
Marwa Mahmoud, Ian M Evans, Vedanta Mehta, Caroline Pellet-Many, Ketevan Paliashvili, Ian Zachary

Am J Physiol Cell Physiol· March 2019

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VEGF (Vascular Endothelial Growth Factor) Induces NRP1 (Neuropilin-1) Cleavage via ADAMs (a Disintegrin and Metalloproteinase) 9 and 10 to Generate Novel Carboxy-Terminal NRP1 Fragments That Regulate Angiogenic Signaling.
Vedanta Mehta, Laura Fields, Ian M Evans, Maiko Yamaji, Caroline Pellet-Many, Ian Zachary

Arterioscler Thromb Vasc Biol· August 2018

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Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells.
Jonathan Powell, Filipa Mota, David Steadman, Christelle Soudy, Jeremy T Miyauchi, Ian C Zachary

J Med Chem· May 2018

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Architecture and hydration of the arginine-binding site of neuropilin-1.
Filipa Mota, Constantina Fotinou, Rohini R Rana, A W Edith Chan, Tamas Yelland, Ian Zachary

FEBS J· April 2018

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Receptor Tyrosine Kinase Ubiquitination and De-Ubiquitination in Signal Transduction and Receptor Trafficking.
William R Critchley, Caroline Pellet-Many, Benjamin Ringham-Terry, Michael A Harrison, Ian C Zachary

Cells· March 2018

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Vascular Endothelial Growth Factor (VEGF) Promotes Assembly of the p130Cas Interactome to Drive Endothelial Chemotactic Signaling and Angiogenesis.
Ian M Evans, Susan A Kennedy, Ketevan Paliashvili, Tapesh Santra, Maiko Yamaji, Ian C Zachary

Mol Cell Proteomics· February 2017

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Maternal Therapy with Ad.VEGF-A Increases Fetal Weight at Term in a Guinea-Pig Model of Fetal Growth Restriction.
Anna M Swanson, Carlo A Rossi, Keren Ofir, Vedanta Mehta, Michael Boyd, Ian Zachary

Hum Gene Ther· December 2016

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Gene Targeting to the Uteroplacental Circulation of Pregnant Guinea Pigs.
Vedanta Mehta, Keren Ofir, Anna Swanson, Ewa Kloczko, Michael Boyd, Ian Zachary

Reprod Sci· August 2016

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Peri- and Postnatal Effects of Prenatal Adenoviral VEGF Gene Therapy in Growth-Restricted Sheep.
David J Carr, Jacqueline M Wallace, Raymond P Aitken, John S Milne, John F Martin, Ian C Zachary

Biol Reprod· June 2016

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Imatinib and Nilotinib increase glioblastoma cell invasion via Abl-independent stimulation of p130Cas and FAK signalling.
Antonina Frolov, Ian M Evans, Ningning Li, Kastytis Sidlauskas, Ketevan Paliashvili, Ian C Zachary

Sci Rep· June 2016

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Structural studies of neuropilin-2 reveal a zinc ion binding site remote from the vascular endothelial growth factor binding pocket.
Yi-Chun Isabella Tsai, Constantina Fotinou, Rohini Rana, Tamas Yelland, Paul Frankel, Ian Zachary

FEBS J· May 2016

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VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis.
Gareth W Fearnley, Gina A Smith, Izma Abdul-Zani, Nadira Yuldasheva, Nadeem A Mughal, Ian C Zachary

Biol Open· May 2016

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Ablation of Neuropilin 1 from glioma-associated microglia and macrophages slows tumor progression.
Jeremy T Miyauchi, Danling Chen, Matthew Choi, Jillian C Nissen, Kenneth R Shroyer, Ian C Zachary

Oncotarget· March 2016

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Neuropilins 1 and 2 mediate neointimal hyperplasia and re-endothelialization following arterial injury.
Caroline Pellet-Many, Vedanta Mehta, Laura Fields, Marwa Mahmoud, Vanessa Lowe, Ian Zachary

Cardiovasc Res· November 2015

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NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells.
Alessandro Fantin, Anastasia Lampropoulou, Gaia Gestri, Claudio Raimondi, Valentina Senatore, Ian Zachary

Cell Rep· June 2015

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