Publications by authors named "Ibrahim F Benter"

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The cardiac toxicity of PAMAM dendrimer drug delivery systems can be attenuated with the adjunct use of cardioprotective agents.
Saghir Akhtar, Fawzi Babiker, Aisha Al-Kouh, Ibrahim F Benter

Biomol Biomed· March 2025

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Targeting the epidermal growth factor receptor (EGFR/ErbB) for the potential treatment of renal pathologies.
Mohamed Tawengi, Yazan Al-Dali, Abdelaziz Tawengi, Ibrahim F Benter, Saghir Akhtar

Front Pharmacol· August 2024

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Mitigating Cardiotoxicity of Dendrimers: Angiotensin-(1-7) via Its Mas Receptor Ameliorates PAMAM-Induced Cardiac Dysfunction in the Isolated Mammalian Heart.
Saghir Akhtar, Fawzi Babiker, Usman A Akhtar, Ibrahim F Benter

Pharmaceutics· December 2022

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Emerging innate biological properties of nano-drug delivery systems: A focus on PAMAM dendrimers and their clinical potential.
Hadeel Kheraldine, Ousama Rachid, Abdella M Habib, Ala-Eddin Al Moustafa, Ibrahim F Benter

Adv Drug Deliv Rev· November 2021

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The Role of Epidermal Growth Factor Receptor Family of Receptor Tyrosine Kinases in Mediating Diabetes-Induced Cardiovascular Complications.
Bara A Shraim, Moaz O Moursi, Ibrahim F Benter, Abdella M Habib, Saghir Akhtar

Front Pharmacol· August 2021

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Pharmacotherapy in COVID-19 patients: a review of ACE2-raising drugs and their clinical safety.
Saghir Akhtar, Ibrahim F Benter, Mohammed I Danjuma, Suhail A R Doi, Syed S Hasan

J Drug Target· September 2020

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Nanotoxicology of Dendrimers in the Mammalian Heart: ex vivo and in vivo Administration of G6 PAMAM Nanoparticles Impairs Recovery of Cardiac Function Following Ischemia-Reperfusion Injury.
Fawzi Babiker, Ibrahim F Benter, Saghir Akhtar

Int J Nanomedicine· August 2020

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Ang-(1-7)/ MAS1 receptor axis inhibits allergic airway inflammation via blockade of Src-mediated EGFR transactivation in a murine model of asthma.
Ahmed Z El-Hashim, Maitham A Khajah, Rhema S Babyson, Waleed M Renno, Charles I Ezeamuzie, Ibrahim F Benter

PLoS One· March 2020

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Chronic administration of nano-sized PAMAM dendrimers in vivo inhibits EGFR-ERK1/2-ROCK signaling pathway and attenuates diabetes-induced vascular remodeling and dysfunction.
Saghir Akhtar, Bindu Chandrasekhar, Mariam Hm Yousif, Waleed Renno, Ibrahim F Benter

Nanomedicine· June 2019

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Activation of ErbB2 and Downstream Signalling via Rho Kinases and ERK1/2 Contributes to Diabetes-Induced Vascular Dysfunction.
Saghir Akhtar, Mariam H M Yousif, Gursev S Dhaunsi, Fatma Sarkhouh, Bindu Chandrasekhar, Ibrahim F Benter

PLoS One· October 2017

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Src-dependent EGFR transactivation regulates lung inflammation via downstream signaling involving ERK1/2, PI3Kδ/Akt and NFκB induction in a murine asthma model.
Ahmed Z El-Hashim, Maitham A Khajah, Waleed M Renno, Rhema S Babyson, Mohib Uddin, Ibrahim F Benter

Sci Rep· August 2017

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Angiotensin-(1-7)-dependent vasorelaxation of the renal artery exhibits unique angiotensin and bradykinin receptor selectivity.
Mariam H M Yousif, Ibrahim F Benter, Debra I Diz, Mark C Chappell

Peptides· April 2017

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Angiotensin-(1-7) Downregulates Diabetes-Induced cGMP Phosphodiesterase Activation in Rat Corpus Cavernosum.
Gursev S Dhaunsi, Mariam Yousif, Batoul Makki, Saghir Akhtar, Ibrahim F Benter

Biomed Res Int· April 2017

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Impact of PAMAM delivery systems on signal transduction pathways in vivo: Modulation of ERK1/2 and p38 MAP kinase signaling in the normal and diabetic kidney.
Saghir Akhtar, Bashayer Al-Zaid, Ahmed Z El-Hashim, Bindu Chandrasekhar, Sreeja Attur, Ibrahim F Benter

Int J Pharm· December 2016

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Transactivation of ErbB Family of Receptor Tyrosine Kinases Is Inhibited by Angiotensin-(1-7) via Its Mas Receptor.
Saghir Akhtar, Bindu Chandrasekhar, Sreeja Attur, Gursev S Dhaunsi, Mariam H M Yousif, Ibrahim F Benter

PLoS One· June 2016

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Naked Polyamidoamine Polymers Intrinsically Inhibit Angiotensin II-Mediated EGFR and ErbB2 Transactivation in a Dendrimer Generation- and Surface Chemistry-Dependent Manner.
Saghir Akhtar, Ahmed Z El-Hashim, Bindu Chandrasekhar, Sreeja Attur, Ibrahim F Benter

Mol Pharm· May 2016

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The dual targeting of EGFR and ErbB2 with the inhibitor Lapatinib corrects high glucose-induced apoptosis and vascular dysfunction by opposing multiple diabetes-induced signaling changes.
Ibrahim F Benter, Fatima Sarkhou, Abeer T Al-Khaldi, Bindu Chandrasekhar, Sreeja Attur

J Drug Target· April 2016

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Cationic Polyamidoamine Dendrimers as Modulators of EGFR Signaling In Vitro and In Vivo.
Saghir Akhtar, Bashayer Al-Zaid, Ahmed Z El-Hashim, Bindu Chandrasekhar, Sreeja Attur, Ibrahim F Benter

PLoS One· April 2016

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Endogenous angiotensin-(1-7)/Mas receptor/NO pathway mediates the cardioprotective effects of pacing postconditioning.
Ala'a Abwainy, Fawzi Babiker, Saghir Akhtar, Ibrahim F Benter

Am J Physiol Heart Circ Physiol· January 2016

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Chronic treatment with Ang-(1-7) reverses abnormal reactivity in the corpus cavernosum and normalizes diabetes-induced changes in the protein levels of ACE, ACE2, ROCK1, ROCK2 and omega-hydroxylase in a rat model of type 1 diabetes.
Mariam H M Yousif, Batoul Makki, Ahmed Z El-Hashim, Saghir Akhtar, Ibrahim F Benter

J Diabetes Res· February 2015

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RU28318, an aldosterone antagonist, in combination with an ACE inhibitor and angiotensin receptor blocker attenuates cardiac dysfunction in diabetes.
Ibrahim F Benter, Fawzi Babiker, Ibrahim Al-Rashdan, Mariam Yousif, Saghir Akhtar

J Diabetes Res· January 2014

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Role of angiotensin II and angiotensin-(1-7) in diabetes-induced oxidative DNA damage in the corpus cavernosum.
Narayana Kilarkaje, Mariam H M Yousif, Ahmed Z El-Hashim, Batoul Makki, Saghir Akhtar, Ibrahim F Benter

Fertil Steril· July 2013

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On the nanotoxicity of PAMAM dendrimers: Superfect® stimulates the EGFR-ERK1/2 signal transduction pathway via an oxidative stress-dependent mechanism in HEK 293 cells.
Saghir Akhtar, Bindu Chandrasekhar, Sreeja Attur, Mariam H M Yousif, Ibrahim F Benter

Int J Pharm· May 2013

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The role of epidermal growth factor receptor in diabetes-induced cardiac dysfunction.
Saghir Akhtar, Ibrahim Fadil Benter

Bioimpacts· May 2013

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Chronic treatment with LY294002, an inhibitor of phosphatidylinositol 3-kinase, attenuates ischemia/reperfusion-induced cardiac dysfunction in normotensive and hypertensive diabetic animals.
Ibrahim F Benter, Ibrahim Al-Rashdan, Jasbir S Juggi, Mariam H M Yousif, Saghir Akhtar

Mol Cell Biochem· January 2013

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