Publications by authors named "Ignacio Brouard"

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Structure-activity relationships reveal a 4-(2-pyridyl)chalcone as a potent cell death inducer.
Juan Perdomo, Henoc Del Rosario, Ester Saavedra, Mercedes Said, Celina García, Ignacio Brouard

Chem Biol Interact· December 2025

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Guanidine Derivatives Containing the Chalcone Skeleton Are Potent Antiproliferative Compounds against Human Leukemia Cells.
Francisco Estévez-Sarmiento, Ester Saavedra, Ignacio Brouard, Jesús Peyrac, Judith Hernández-Garcés

Int J Mol Sci· December 2022

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Structure-activity relationships reveal a 2-furoyloxychalcone as a potent cytotoxic and apoptosis inducer for human U-937 and HL-60 leukaemia cells.
Henoc Del Rosario, Ester Saavedra, Ignacio Brouard, Daniel González-Santana, Celina García

Bioorg Chem· October 2022

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Chlorinated Guaiane-Type Sesquiterpene Lactones as Cytotoxic Agents against Human Tumor Cells.
Francisco Estévez-Sarmiento, Ester Saavedra, Mercedes Ruiz-Estévez, Francisco León, José Quintana, Ignacio Brouard

Int J Mol Sci· December 2020

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The synthetic flavanone 6-methoxy-2-(naphthalen-1-yl)chroman-4-one induces apoptosis and activation of the MAPK pathway in human U-937 leukaemia cells.
Ester Saavedra, Henoc Del Rosario, Ignacio Brouard, Judith Hernández-Garcés, Celina García

Bioorg Chem· January 2020

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Coss. & Dur. (Asteraceae) extracts: New cyanogenic glucoside and other constituents.
Samia Baatouche, Thamere Cheriet, Djamel Sarri, Ratiba Mekkiou, Ouahiba Boumaza, Ignacio Brouard

Nat Prod Res· November 2019

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6'-Benzyloxy-4-bromo-2'-hydroxychalcone is cytotoxic against human leukaemia cells and induces caspase-8- and reactive oxygen species-dependent apoptosis.
Ester Saavedra, Henoc Del Rosario, Ignacio Brouard, José Quintana, Francisco Estévez

Chem Biol Interact· January 2019

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3'-Hydroxy-3,4'-dimethoxyflavone-induced cell death in human leukaemia cells is dependent on caspases and reactive oxygen species and attenuated by the inhibition of JNK/SAPK.
Francisco Estévez-Sarmiento, Elisa Hernández, Ignacio Brouard, Francisco León, Celina García

Chem Biol Interact· May 2018

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3'-Hydroxy-3,4'-dimethoxyflavone blocks tubulin polymerization and is a potent apoptotic inducer in human SK-MEL-1 melanoma cells.
Francisco Estévez-Sarmiento, Mercedes Said, Ignacio Brouard, Francisco León, Celina García

Bioorg Med Chem· November 2017

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Antiproliferative activity and apoptosis induction by 3',4'-dibenzyloxyflavonol on human leukemia cells.
Mercedes Said, Ignacio Brouard, José Quintana, Francisco Estévez

Chem Biol Interact· April 2017

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Sesquiterpenoids Isolated from Two Species of the Asteriscus Alliance.
Jorge Triana, José Luis Eiroa, Manuel Morales, Francisco J Perez, Ignacio Brouard

J Nat Prod· May 2016

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New quinoline alkaloid from Ruta graveolens aerial parts and evaluation of the antifertility activity.
Josline Y Salib, Sayed A El-Toumy, Emad M Hassan, Nabila H Shafik, Sally M Abdel-Latif, Ignacio Brouard

Nat Prod Res· December 2014

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Synthesis and effects on cell viability of flavonols and 3-methyl ether derivatives on human leukemia cells.
Olga Burmistrova, María Teresa Marrero, Sara Estévez, Isabel Welsch, Ignacio Brouard

Eur J Med Chem· September 2014

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A chemotaxonomic study of endemic species of genus Tanacetum from the Canary Islands.
Jorge Triana, José Luis Eiroa, Manuel Morales, Francisco J Pérez, Ignacio Brouard

Phytochemistry· August 2013

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Multicomponent ligation of steroids: creating diversity at the linkage moiety of bis-spirostanic conjugates by Ugi reactions.
Karell Pérez-Labrada, Yanira Méndez, Ignacio Brouard, Daniel G Rivera

ACS Comb Sci· June 2013

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Secondary metabolites from two species of Tolpis and their biological activities.
Jorge Triana, Mariana López, Francisco Javier Pérez, Milagros Rico, Aroa López, Ignacio Brouard

Molecules· November 2012

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Effect of C-ring modifications on the cytotoxicity of spirostan saponins and related glycosides.
Karell Pérez-Labrada, Ignacio Brouard, Sara Estévez, María Teresa Marrero, Francisco Estévez

Bioorg Med Chem· July 2012

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Multicomponent synthesis of Ugi-type ceramide analogues and neoglycolipids from lipidic isocyanides.
Karell Pérez-Labrada, Ignacio Brouard, Inmaculada Méndez, Daniel G Rivera

J Org Chem· May 2012

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A new flavonoid and other constituents from Centaurea nicaeensis All. var. walliana M.
Leila Hammoud, Ramdane Seghiri, Samir Benayache, Paul Mosset, Annelise Lobstein, Ignacio Brouard

Nat Prod Res· April 2012

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New insights into the structure-cytotoxicity relationship of spirostan saponins and related glycosides.
Karell Pérez-Labrada, Ignacio Brouard, Sara Estévez, María Teresa Marrero, Francisco Estévez

Bioorg Med Chem· April 2012

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Secondary metabolites from two species of Pulicaria and their cytotoxic activity.
Jorge Triana, Mariana López, Francisco Javier Pérez, Francisco León, José Quintana, Ignacio Brouard

Chem Biodivers· November 2011

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Chemotaxonomy of Gonospermum and related genera.
Jorge Triana, José Luis Eiroa, Juan José Ortega, Francisco León, Ignacio Brouard

Phytochemistry· April 2010

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Chemical constituents of Tolpis species.
Jorge Triana, Mariana López, Francisco Javier Pérez, Javier González Platas, Francisco Estévez, Ignacio Brouard

Fitoterapia· October 2009

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Sesquiterpene lactones from Gonospermum gomerae and G. fruticosum and their cytotoxic activities.
Jorge Triana, José Luis Eiroa, Juan José Ortega, Francisco León, Ignacio Brouard

J Nat Prod· December 2008

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A new ceramide from Suillus luteus and its cytotoxic activity against human melanoma cells.
Francisco León, Ignacio Brouard, Fernando Torres, José Quintana, Augusto Rivera

Chem Biodivers· January 2008

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