Publications by authors named "Igor Medina"

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Exploring the Cell Biological and Functional Effects of the First Disease Associated KCC1 Genetic Variant.
Meye Bloothooft, Jiahui Huang, Mira Hamze, Marien J C Houtman, Teun P de Boer, Igor Medina

J Cell Physiol· December 2025

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Altered GABAergic signaling and chloride homeostasis in eye movement circuits during late neurodevelopment: implications for Alzheimer's disease therapy.
Christophe Porcher, Claudio Rivera, Igor Medina, Lejla Koric

Front Pharmacol· November 2025

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Editorial: SLC12A5-dependent neurological disorders.
Igor Medina, Amy McTague, Coralie Di Scala, Claudio Rivera

Front Mol Neurosci· May 2025

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Regulation of Neuronal Chloride Homeostasis by Pro- and Mature Brain-Derived Neurotrophic Factor (BDNF) via KCC2 Cation-Chloride Cotransporters in Rat Cortical Neurons.
Mira Hamze, Cathy Brier, Emmanuelle Buhler, Jinwei Zhang, Igor Medina

Int J Mol Sci· June 2024

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A novel pathogenic missense variant in epilepsy of infancy with migrating focal seizures causes impaired KCC2 chloride extrusion.
Viivi Järvelä, Mira Hamze, Jonna Komulainen-Ebrahim, Elisa Rahikkala, Johanna Piispala, Igor Medina

Front Mol Neurosci· April 2024

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K/Cl cotransporter 2 (KCC2) and Na/ cotransporter 1 (NBCe1) interaction modulates profile of KCC2 phosphorylation.
Abhishek Pethe, Mira Hamze, Marina Giannaki, Bernd Heimrich, Igor Medina

Front Cell Neurosci· October 2023

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Oxytocin administration in neonates shapes hippocampal circuitry and restores social behavior in a mouse model of autism.
Alessandra Bertoni, Fabienne Schaller, Roman Tyzio, Stephane Gaillard, Francesca Santini, Igor Medina

Mol Psychiatry· December 2021

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Contribution of Smoothened Receptor Signaling in GABAergic Neurotransmission and Chloride Homeostasis in the Developing Rodent Brain.
Mira Hamze, Igor Medina, Quentin Delmotte, Christophe Porcher

Front Physiol· December 2021

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Leptin increases GABAergic synaptogenesis through the Rho guanine exchange factor β-PIX in developing hippocampal neurons.
Gulcan Semra Sahin, Jose Luis Rodriguez-Llamas, Crystal Dillon, Igor Medina, Suzanne M Appleyard

Sci Signal· May 2021

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Smoothened receptor signaling regulates the developmental shift of GABA polarity in rat somatosensory cortex.
Quentin Delmotte, Mira Hamze, Igor Medina, Emmanuelle Buhler, Jinwei Zhang

J Cell Sci· October 2020

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Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1.
Jinwei Zhang, Antje Cordshagen, Igor Medina, Hans Gerd Nothwang, Jacek R Wisniewski

PLoS One· August 2020

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Impaired regulation of KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathology.
Lucie I Pisella, Jean-Luc Gaiarsa, Diabé Diabira, Jinwei Zhang, Ilgam Khalilov, Igor Medina

Sci Signal· October 2019

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The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice.
Camille Dumon, Diabe Diabira, Ilona Chudotvorova, Francesca Bader, Semra Sahin, Igor Medina

Elife· August 2018

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Mechanism of BDNF Modulation in GABAergic Synaptic Transmission in Healthy and Disease Brains.
Christophe Porcher, Igor Medina, Jean-Luc Gaiarsa

Front Cell Neurosci· August 2018

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A Novel View on the Role of Intracellular Tails in Surface Delivery of the Potassium-Chloride Cotransporter KCC2.
Perrine Friedel, Anastasia Ludwig, Christophe Pellegrino, Morgane Agez, Anass Jawhari, Igor Medina

eNeuro· April 2018

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The small molecule CLP257 does not modify activity of the K-Cl co-transporter KCC2 but does potentiate GABA receptor activity.
Ross A Cardarelli, Karen Jones, Lucie I Pisella, Heike J Wobst, Lisa J McWilliams, Igor Medina

Nat Med· December 2017

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Molecular architecture of potassium chloride co-transporter KCC2.
Morgane Agez, Patrick Schultz, Igor Medina, David J Baker, Matthew P Burnham

Sci Rep· November 2017

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Molecular cloning and biochemical characterization of two cation chloride cotransporter subfamily members of Hydra vulgaris.
Anna-Maria Hartmann, Lucie I Pisella, Igor Medina, Hans Gerd Nothwang

PLoS One· October 2017

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KCC2 regulates actin dynamics in dendritic spines via interaction with β-PIX.
Olaya Llano, Sergey Smirnov, Shetal Soni, Andrey Golubtsov, Isabelle Guillemin, Igor Medina

J Cell Biol· June 2015

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WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons.
Perrine Friedel, Kristopher T Kahle, Jinwei Zhang, Nicholas Hertz, Lucie I Pisella, Igor Medina

Sci Signal· June 2015

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Pro-brain-derived neurotrophic factor inhibits GABAergic neurotransmission by activating endocytosis and repression of GABAA receptors.
Baptiste Riffault, Igor Medina, Camille Dumon, Carine Thalman, Nadine Ferrand

J Neurosci· October 2014

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Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy.
Kristopher T Kahle, Nancy D Merner, Perrine Friedel, Liliya Silayeva, Bo Liang, Igor Medina

EMBO Rep· July 2014

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Current view on the functional regulation of the neuronal K(+)-Cl(-) cotransporter KCC2.
Igor Medina, Perrine Friedel, Claudio Rivera, Kristopher T Kahle, Nazim Kourdougli

Front Cell Neurosci· April 2014

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Improved method for efficient imaging of intracellular Cl(-) with Cl-Sensor using conventional fluorescence setup.
Perrine Friedel, Piotr Bregestovski, Igor Medina

Front Mol Neurosci· April 2013

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Enhanced Synaptic Activity and Epileptiform Events in the Embryonic KCC2 Deficient Hippocampus.
Ilgam Khalilov, Geneviève Chazal, Ilona Chudotvorova, Christophe Pellegrino, Séverine Corby, Igor Medina

Front Cell Neurosci· November 2011

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