Publications by authors named "Ina Kramer"

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Discovery and Characterization of Zilurgisertib, a Potent and Selective Inhibitor of Activin Receptor-like Kinase‑2 (ALK2) for the Treatment of Fibrodysplasia Ossificans Progressiva.
Thomas Ullrich, Sabine Guth, Luca Arista, Sven Weiler, Nikolaus Stiefl, Ina Kramer

ACS Med Chem Lett· November 2025

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An Additional Lrp4 High Bone Mass Mutation Mitigates the Sost-Knockout Phenotype in Mice by Increasing Bone Remodeling.
Gretl Hendrickx, Eveline Boudin, Ligia Mateiu, Timur A Yorgan, Ellen Steenackers, Ina Kramer

Calcif Tissue Int· February 2024

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Surface modified cationic PLGA microparticles as long-acting injectable carriers for intra-articular small molecule drug delivery.
Niranjan G Kotla, Jean-Baptiste Langlois, Andreas Fisch, Ina Kramer, Christine Halleux

Eur J Pharm Biopharm· October 2023

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Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5.
Cassandra R Diegel, Ina Kramer, Charles Moes, Gabrielle E Foxa, Mitchell J McDonald

Bone Res· August 2023

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Specific preadaptations of Rhodococcus equi cooperate with its Virulence-associated protein A during macrophage infection.
Thomas Haubenthal, Philipp Hansen, Ina Krämer, Mélanie Gindt, Alexandra Jünger-Leif

Mol Microbiol· March 2023

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Angiopoietin-like 3-derivative LNA043 for cartilage regeneration in osteoarthritis: a randomized phase 1 trial.
Nicole Gerwin, Celeste Scotti, Christine Halleux, Mara Fornaro, Jimmy Elliott, Ina Kramer

Nat Med· December 2022

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Discovery of a novel 2-aminopyrazine-3-carboxamide as a potent and selective inhibitor of Activin Receptor-Like Kinase-2 (ALK2) for the treatment of fibrodysplasia ossificans progressiva.
Thomas Ullrich, Luca Arista, Sven Weiler, Sylvie Teixeira-Fouchard, Valérie Broennimann, Ina Kramer

Bioorg Med Chem Lett· May 2022

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Blockage of bone morphogenetic protein signalling counteracts hypertrophy in a human osteoarthritic micro-cartilage model.
Shikha Chawla, Majoska H M Berkelaar, Boris Dasen, Christine Halleux, Sabine Guth-Gundel, Ina Kramer

J Cell Sci· December 2020

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Cortical bone adaptation to a moderate level of mechanical loading in male Sost deficient mice.
Haisheng Yang, Alexander Büttner, Laia Albiol, Catherine Julien, Tobias Thiele, Ina Kramer

Sci Rep· December 2020

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Effects of Long-Term Sclerostin Deficiency on Trabecular Bone Mass and Adaption to Limb Loading Differ in Male and Female Mice.
Laia Albiol, Alexander Büttner, David Pflanz, Nicholas Mikolajewicz, Annette I Birkhold, Ina Kramer

Calcif Tissue Int· April 2020

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Interleukin-17A Inhibition Diminishes Inflammation and New Bone Formation in Experimental Spondyloarthritis.
Melissa N van Tok, Leonie M van Duivenvoorde, Ina Kramer, Peter Ingold, Sabina Pfister

Arthritis Rheumatol· April 2019

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Virulence-associated protein A from Rhodococcus equi is an intercompartmental pH-neutralising virulence factor.
Kristine von Bargen, Mirella Scraba, Ina Krämer, Maren Ketterer, Christian Nehls

Cell Microbiol· January 2019

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Dkk1 KO Mice Treated with Sclerostin Antibody Have Additional Increases in Bone Volume.
Alyson Morse, Tegan L Cheng, Aaron Schindeler, Michelle M McDonald, Sindhu T Mohanty, Ina Kramer

Calcif Tissue Int· September 2018

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Developmentally inspired programming of adult human mesenchymal stromal cells toward stable chondrogenesis.
Paola Occhetta, Sebastien Pigeot, Marco Rasponi, Boris Dasen, Arne Mehrkens, Ina Kramer

Proc Natl Acad Sci U S A· May 2018

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deficiency leads to reduced mechanical strains at the tibia midshaft in strain-matched loading experiments in mice.
Laia Albiol, Myriam Cilla, David Pflanz, Ina Kramer, Michaela Kneissel

J R Soc Interface· April 2018

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Sclerostin Antibody Augments the Anabolic Bone Formation Response in a Mouse Model of Mechanical Tibial Loading.
Alyson Morse, Aaron Schindeler, Michelle M McDonald, Michaela Kneissel, Ina Kramer

J Bone Miner Res· March 2018

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The skeletal cell-derived molecule sclerostin drives bone marrow adipogenesis.
Heather Fairfield, Carolyne Falank, Elizabeth Harris, Victoria Demambro, Michelle McDonald, Ina Kramer

J Cell Physiol· February 2018

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Loading-Induced Reduction in Sclerostin as a Mechanism of Subchondral Bone Plate Sclerosis in Mouse Knee Joints During Late-Stage Osteoarthritis.
Haoruo Jia, Xiaoyuan Ma, Yulong Wei, Wei Tong, Robert J Tower, Ina Kramer

Arthritis Rheumatol· February 2018

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Sclerostin deficiency modifies the development of CKD-MBD in mice.
Nadine Kaesler, Anja Verhulst, Annelies De Maré, Annika Deck, Geert J Behets, Ina Kramer

Bone· February 2018

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Combination sclerostin antibody and zoledronic acid treatment outperforms either treatment alone in a mouse model of osteogenesis imperfecta.
David G Little, Lauren Peacock, Kathy Mikulec, Michaela Kneissel, Ina Kramer

Bone· August 2017

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Sost deficiency led to a greater cortical bone formation response to mechanical loading and altered gene expression.
David Pflanz, Annette I Birkhold, Laia Albiol, Tobias Thiele, Catherine Julien, Ina Kramer

Sci Rep· August 2017

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Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma.
Michelle M McDonald, Michaela R Reagan, Scott E Youlten, Sindhu T Mohanty, Anja Seckinger, Ina Kramer

Blood· June 2017

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Suppression of Sclerostin Alleviates Radiation-Induced Bone Loss by Protecting Bone-Forming Cells and Their Progenitors Through Distinct Mechanisms.
Abhishek Chandra, Tiao Lin, Tiffany Young, Wei Tong, Xiaoyuan Ma, Ina Kramer

J Bone Miner Res· February 2017

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Only minor differences in renal osteodystrophy features between wild-type and sclerostin knockout mice with chronic kidney disease.
Daniel Cejka, Diego Parada-Rodriguez, Stefanie Pichler, Rodrig Marculescu, Ina Kramer

Kidney Int· October 2016

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Meckel's and condylar cartilages anomalies in achondroplasia result in defective development and growth of the mandible.
Martin Biosse Duplan, Davide Komla-Ebri, Yann Heuzé, Valentin Estibals, Emilie Gaudas, Ina Kramer

Hum Mol Genet· July 2016

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