Publications by authors named "Inna Astapova"

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Genetics-nutrition interactions control diurnal enhancer-promoter dynamics and liver lipid metabolism.
Dishu Zhou, Ying Chen, Panpan Liu, Kun Zhu, Juliet Holder-Haynes, Inna I Astapova

Cell Metab· October 2025

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Integration of metabolomic and transcriptomic analyses reveals regulatory functions of the ChREBP transcription factor in energy metabolism.
Jie An, Inna Astapova, Guofang Zhang, Andrew L Cangelosi, Olga Ilkayeva

Cell Rep· February 2025

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Integration of metabolomic and transcriptomic analyses reveals novel regulatory functions of the ChREBP transcription factor in energy metabolism.
Jie An, Inna Astapova, Guofang Zhang, Andrew L Cangelosi, Olga Ilkayeva

bioRxiv· September 2024

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"Metformin Impairs Intestinal Fructose Metabolism".
Wenxin Tong, Sarah A Hannou, Ashot Sargsyan, Guo-Fang Zhang, Paul A Grimsrud, Inna Astapova

bioRxiv· May 2023

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HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis.
Ashot Sargsyan, Ludivine Doridot, Sarah A Hannou, Wenxin Tong, Harini Srinivasan, Inna Astapova

JCI Insight· January 2023

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The intestine is a major contributor to circulating succinate in mice.
Wenxin Tong, Sarah A Hannou, You Wang, Inna Astapova, Ashot Sargsyan

FASEB J· October 2022

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A Systems Approach Dissociates Fructose-Induced Liver Triglyceride from Hypertriglyceridemia and Hyperinsulinemia in Male Mice.
Ludivine Doridot, Sarah A Hannou, Sarah A Krawczyk, Wenxin Tong, Mi-Sung Kim, Inna I Astapova

Nutrients· October 2021

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The Limited Role of Glucagon for Ketogenesis During Fasting or in Response to SGLT2 Inhibition.
Megan E Capozzi, Reilly W Coch, Jepchumba Koech, Inna I Astapova, Jacob B Wait

Diabetes· May 2020

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Nuclear corepressor SMRT is a strong regulator of body weight independently of its ability to regulate thyroid hormone action.
Hiroaki Shimizu, Yu Lu, Kristen R Vella, Federico Damilano, Inna Astapova

PLoS One· March 2020

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Genetic and Pharmacological Targeting of Transcriptional Repression in Resistance to Thyroid Hormone Alpha.
Bernard Freudenthal, Samiksha Shetty, Natalie C Butterfield, John G Logan, Cho Rong Han, Inna Astapova

Thyroid· May 2019

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Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis.
Pengcheng Bu, Kai-Yuan Chen, Kun Xiang, Christelle Johnson, Scott B Crown, Inna Astapova

Cell Metab· June 2018

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The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.
Phillip J White, Robert W McGarrah, Paul A Grimsrud, Shih-Chia Tso, Wen-Hsuan Yang, Inna Astapova

Cell Metab· June 2018

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Intestinal, but not hepatic, ChREBP is required for fructose tolerance.
MiSung Kim, Inna I Astapova, Sarah N Flier, Sarah A Hannou, Ludivine Doridot

JCI Insight· December 2017

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NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor.
Arturo Mendoza, Inna Astapova, Hiroaki Shimizu, Molly R Gallop, Lujain Al-Sowaimel

Proc Natl Acad Sci U S A· October 2017

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Role of co-regulators in metabolic and transcriptional actions of thyroid hormone.
Inna Astapova

J Mol Endocrinol· April 2016

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Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition.
Brijesh K Singh, Rohit A Sinha, Jin Zhou, Madhulika Tripathi, Kenji Ohba, Inna Astapova

J Biol Chem· January 2016

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Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells.
Anita A Kurmann, Maria Serra, Finn Hawkins, Scott A Rankin, Munemasa Mori, Inna Astapova

Cell Stem Cell· November 2015

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NCoR1 and SMRT play unique roles in thyroid hormone action in vivo.
Hiroaki Shimizu, Inna Astapova, Felix Ye, Martin Bilban, Ronald N Cohen

Mol Cell Biol· February 2015

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Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors.
Kristen R Vella, Preeti Ramadoss, Ricardo H Costa-E-Sousa, Inna Astapova, Felix D Ye

Mol Cell Biol· May 2014

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Fibroblast growth factor 21 and thyroid hormone show mutual regulatory dependency but have independent actions in vivo.
Eleni M Domouzoglou, Ffolliott Martin Fisher, Inna Astapova, Elliott C Fox, Alexei Kharitonenkov

Endocrinology· May 2014

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Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRβ1-governed pathway.
Inna Astapova, Preeti Ramadoss, Ricardo H Costa-e-Sousa, Felix Ye, Kaila A Holtz

J Clin Invest· May 2014

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The in vivo role of nuclear receptor corepressors in thyroid hormone action.
Inna Astapova, Anthony N Hollenberg

Biochim Biophys Acta· July 2013

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The thyroid axis is regulated by NCoR1 via its actions in the pituitary.
Ricardo H Costa-e-Sousa, Inna Astapova, Felix Ye, Fredric E Wondisford, Anthony N Hollenberg

Endocrinology· October 2012

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Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1).
Laura Fozzatti, Changxue Lu, Dong Wook Kim, Jeong Won Park, Inna Astapova

Proc Natl Acad Sci U S A· October 2011

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The nuclear receptor corepressor (NCoR) controls thyroid hormone sensitivity and the set point of the hypothalamic-pituitary-thyroid axis.
Inna Astapova, Kristen R Vella, Preeti Ramadoss, Kaila A Holtz, Benjamin A Rodwin

Mol Endocrinol· February 2011

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