Publications by authors named "Isaac A Chaim"

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Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development.
Cleber A Trujillo, Richard Gao, Priscilla D Negraes, Jing Gu, Justin Buchanan, Sebastian Preissl, Allen Wang, Wei Wu, Gabriel G Haddad, Isaac A Chaim

Cell Stem Cell· October 2019

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Comprehensive Measurement of Inter-Individual Variation in DNA Repair Capacity in Healthy Individuals.
Ting Zhai, Patrizia Mazzucato, Catherine Ricciardi, David C Christiani, Liming Liang, Isaac A Chaim

Adv Sci (Weinh)· December 2025

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Comprehensive Measurement of Inter-Individual Variation in DNA Repair Capacity in Healthy Individuals.
Ting Zhai, Patrizia Mazzucato, Catherine Ricciardi, David C Christiani, Liming Liang, Isaac A Chaim

medRxiv· June 2025

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Mapping the future of oxidative RNA damage in neurodegeneration: Rethinking the status quo with new tools.
Hailey B Wheeler, Assael A Madrigal, Isaac A Chaim

Proc Natl Acad Sci U S A· November 2024

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MECP2-related pathways are dysregulated in a cortical organoid model of myotonic dystrophy.
Kathryn H Morelli, Wenhao Jin, Shashank Shathe, Assael A Madrigal, Krysten L Jones, Isaac A Chaim

Sci Transl Med· June 2022

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CometChip analysis of human primary lymphocytes enables quantification of inter-individual differences in the kinetics of repair of oxidative DNA damage.
Le P Ngo, Simran Kaushal, Isaac A Chaim, Patrizia Mazzucato, Catherine Ricciardi

Free Radic Biol Med· October 2021

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Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer.
Jaclyn M Einstein, Mark Perelis, Isaac A Chaim, Jitendra K Meena, Julia K Nussbacher

Mol Cell· August 2021

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Robust single-cell discovery of RNA targets of RNA-binding proteins and ribosomes.
Kristopher W Brannan, Isaac A Chaim, Ryan J Marina, Brian A Yee, Eric R Kofman

Nat Methods· May 2021

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Reintroduction of the archaic variant of in cortical organoids alters neurodevelopment.
Cleber A Trujillo, Edward S Rice, Nathan K Schaefer, Isaac A Chaim, Emily C Wheeler

Science· February 2021

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Author Correction: Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells.
Tomoyuki Koga, Isaac A Chaim, Jorge A Benitez, Sebastian Markmiller, Alison D Parisian

Nat Commun· April 2020

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Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells.
Tomoyuki Koga, Isaac A Chaim, Jorge A Benitez, Sebastian Markmiller, Alison D Parisian

Nat Commun· January 2020

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Nitric oxide induced S-nitrosation causes base excision repair imbalance.
Marcus C Parrish, Isaac A Chaim, Zachary D Nagel, Steven R Tannenbaum, Leona D Samson

DNA Repair (Amst)· August 2018

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In vivo measurements of interindividual differences in DNA glycosylases and APE1 activities.
Isaac A Chaim, Zachary D Nagel, Jennifer J Jordan, Patrizia Mazzucato, Le P Ngo

Proc Natl Acad Sci U S A· November 2017

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Alkylation induced cerebellar degeneration dependent on Aag and Parp1 does not occur via previously established cell death mechanisms.
Carrie M Margulies, Isaac Alexander Chaim, Aprotim Mazumder, June Criscione, Leona D Samson

PLoS One· October 2017

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Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9.
Ranjan Batra, David A Nelles, Elaine Pirie, Steven M Blue, Ryan J Marina, Isaac A Chaim

Cell· August 2017

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A novel role for transcription-coupled nucleotide excision repair for the in vivo repair of 3,N4-ethenocytosine.
Isaac A Chaim, Alycia Gardner, Jie Wu, Teruaki Iyama, David M Wilson

Nucleic Acids Res· April 2017

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DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme.
Zachary D Nagel, Gaspar J Kitange, Shiv K Gupta, Brian A Joughin, Isaac A Chaim

Cancer Res· January 2017

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Inter-individual variation in DNA repair capacity: a need for multi-pathway functional assays to promote translational DNA repair research.
Zachary D Nagel, Isaac A Chaim, Leona D Samson

DNA Repair (Amst)· July 2014

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Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis.
Zachary D Nagel, Carrie M Margulies, Isaac A Chaim, Siobhan K McRee, Patrizia Mazzucato

Proc Natl Acad Sci U S A· May 2014

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Evaluation of the potential of novel PCL-PPDX biodegradable scaffolds as support materials for cartilage tissue engineering.
Isaac A Chaim, Marcos A Sabino, Mayela Mendt, Alejandro J Müller, Diana Ajami

J Tissue Eng Regen Med· April 2012

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