Cell Stem Cell October 2019 PMID 31474560

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development.

Cleber A Trujillo, Richard Gao, Priscilla D Negraes, Jing Gu, Justin Buchanan, Sebastian Preissl, Allen Wang, Wei Wu, Gabriel G Haddad, Isaac A Chaim, Alain Domissy, Matthieu Vandenberghe, Anna Devor, Gene W Yeo, Bradley Voytek

Mentions

327
Peak: 39 in Aug 2019
across 6 sources since Aug 2019

Extended reach

1,536,325
potential audience

Total likes

14,261

Video views

1,302,485

Mentions per month

Aug 2019 – Jun 2024

Where it's discussed

  • News194 articles
  • X / Twitter72 posts
  • Blogs42 articles
  • Facebook11 posts
  • YouTube4 videos
  • Reddit4 posts

AI synopsis

What people are saying

The group generally agrees on the importance of the study, with many posts highlighting its focus on electrical activity and neural patterns that resemble preterm babies, using words like 'model,' 'structure,' and 'genetic programming' to emphasize scientific relevance. Interest is driven by the innovative use of organoids to mimic brain development, and posts showing detailed references to the oscillatory waves and genetic factors demonstrate active engagement and anticipation of future impact.

AgreementNeither agree nor disagree

Most discussions acknowledge the significance of the research, but some question the direct applicability or caution over the interpretation of findings.

InterestModerate interest

Participants show curiosity about the topic, especially regarding the development of neural networks in organoids and their implications.

EngagementModerate engagement

Several posts reference specific aspects like the oscillatory activity, genetic programming, and methodological details, indicating moderate to deep engagement.

ImpactModerate impact

Discussions suggest that the research could influence future studies in neurodevelopment, with some users noting its potential for understanding early human brain development.

Abstract in brief

  • The study used human cortical organoids to model early human brain development, showing that these brain-like tissues develop electrical activity over several months, with oscillatory waves dependent on specific neurotransmitters like glutamate and GABA.
  • The oscillatory brain activity in these organoids evolves from regular, periodic patterns to more irregular and synchronized events, similar to what is seen in preterm babies' brain activity.
  • The findings suggest that the development of these complex neural network activities might be governed primarily by genetic programming, providing a new way to study and potentially influence early human brain development.]

Top posts

Most liked on X and Bluesky
Cell Stem Cell
@CellStemCell · X

New Paper from Alysson Muotri's Lab @UCSDHealth: "Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development." Interpret w/caution; Organoids are NOT brains, they resemble some features useful for modeling https://t.co/ibJUVMWXVb https://t.co/feJoIN3sDU

Aug 29, 2019 · 26 likes · 13 shares · 58,415 followers View post →
Guillaume Dumas
@introspection · X

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development https://t.co/YksCvXb5Qv cc @DDinWonder https://t.co/w02ZtwSUv9

Aug 31, 2019 · 17 likes · 5 shares · 8,555 followers View post →
Organoid News
@organoidscience · X

*NEW* in @CellStemCell from Dr. Alysson Muotri's lab at @UCSDMedSchool!

Aug 29, 2019 · 13 likes · 7 shares · 13,795 followers View post →
Laurent Nguyen
@neuroliege · X

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development: Cell Stem… https://t.co/HDj2Qm9seN

Aug 29, 2019 · 13 likes · 4 shares · 3,008 followers View post →
Neuroscience and Beyond
@neuro_beyond · X

Our next episode with Dr. @MariaPatapia (Application Specialist at @MBExC_de ) is out!

Apr 24, 2023 · 13 likes · 3 shares · 962 followers View post →
SweetDee
@RealUnsweetDee · X

“The oscillatory activity… resembled features similar to those observed in preterm human electroencephalography. These results show that the development of structured network activity in a human neocortex model may follow stable genetic programming.” https://t.co/3zpn5Cu6Gg

May 29, 2024 · 8 likes · 8,760 followers View post →

All mentions

Immune Support News
@ImmuneHealthNow · X

World's first bioprocessor uses 16 human brain organoids for ‘a million times less power’ consumption than a digital chip https://t.co/7z2dli2v9n Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development https://t.co/cU0WePUMDf

Jun 4, 2024 · 6 followers View post →
Trinity RedorBluePill HiHoKermitTheFrogHere
@TrinityUtube · X

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development https://t.co/jlETLJ069n

May 29, 2024 · 410 followers View post →
SweetDee
@RealUnsweetDee · X

“The oscillatory activity… resembled features similar to those observed in preterm human electroencephalography. These results show that the development of structured network activity in a human neocortex model may follow stable genetic programming.” https://t.co/3zpn5Cu6Gg

May 29, 2024 · 8 likes · 8,760 followers View post →
Carmelo Ferrai
@CarmeloFerrai · X

RT @neuro_beyond: Our next episode with Dr. @MariaPatapia (Application Specialist at @MBExC_de ) is out!

Apr 26, 2023 · 3 shares · 2,486 followers View post →
MBExC
@MBExC_de · X

RT @neuro_beyond: Our next episode with Dr. @MariaPatapia (Application Specialist at @MBExC_de ) is out!

Apr 25, 2023 · 3 shares · 409 followers View post →
Felipe Opazo
@FelipeOpaz_o · X

RT @neuro_beyond: Our next episode with Dr. @MariaPatapia (Application Specialist at @MBExC_de ) is out!

Apr 25, 2023 · 3 shares · 1,912 followers View post →
Neuroscience and Beyond
@neuro_beyond · X

Our next episode with Dr. @MariaPatapia (Application Specialist at @MBExC_de ) is out!

Apr 24, 2023 · 13 likes · 3 shares · 962 followers View post →
Jibran Khokhar
@DrJKhokhar · X

RT @JulioMTNeuro: Good discussion in our JC today presented by @KartikPradeepan on brain organoids and patterns of electrical activity. A t…

Apr 27, 2022 · 1 share · 10,766 followers View post →
Julio Martinez
@JulioMTNeuro · X

Good discussion in our JC today presented by @KartikPradeepan on brain organoids and patterns of electrical activity. A thought provoking work https://t.co/DQHbgUIthJ

Apr 27, 2022 · 8 likes · 1 share · 2,789 followers View post →
Gerold Baier
@GeroldBaier · X

"Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development" https://t.co/hDZEYJ3LBC

Feb 16, 2022 · 566 followers View post →
Simon
@IHearSimon · X

@vickyyyf I'm not sure how the article came up with 'pea-sized'... the study (from 2019) says nothing about that size. https://t.co/moanKr7Te5 This is an example I think of how science is poorly translated in articles meant for general consumption.

Sep 22, 2021 · 2,834 followers View post →
붉은 달의 맹약
@mei_yaku2 · X

결국 만들어진 인공 영혼... 이것이 현대 과학의 힘! 현실판 호문쿨루스가 온다. https://t.co/tlWUdE69ZF 출처 @YouTube

Mar 4, 2021 · 375 followers View post →
omg_toranburu
@omg_toranburu · X

https://t.co/caDSrdsdrH

Feb 24, 2021 · 477 followers View post →
PEMPE
@JG2fCu4jtLU3qLa · X

https://t.co/Yz3rny6WMZ これ

Jan 17, 2021 · 1 like · 142 followers View post →
희원이
@xy212 · X

결국 만들어진 인공 영혼... 이것이 현대 과학의 힘! 현실판 호문쿨루스가 온다. https://t.co/fdPYV9f1ox 출처 @YouTube

Dec 24, 2020 · 244 followers View post →
fitofagos
@fitofagos · X

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development https://t.co/6NPUtTkZ9f #TelegrafíaSinHilos @elotroduarte

Nov 11, 2020 · 1 like · 103 followers View post →
Epigenética
@Epigenetica · X

New in Pubmed: "Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development." https://t.co/VViqPjn5Ex

Sep 22, 2020 · 618 followers View post →
mgl
@mmarland · X

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development | @scoopit https://t.co/S1vUGfVauq

Oct 6, 2019 · 287 followers View post →
Jen Taylor
@jentaylorphd · X

This is cool. Thank you @the_brain_scientist. TLDR: human skin cells >> stem cells >> neurons. Scientist at UCal have grown brains in vitro that developed complex networks over time. Trujillo et al, 2019 Complex Oscillatory ..., Cell Stem Cell Aug 23. 10.1016/j.stem.2019.08.002 https://t.co/I2uGZ9uBLR

Sep 19, 2019 · 1 like · 828 followers View post →
Carolina_Uggenti
@CarolinaUggenti · X

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development https://t.co/Q61yg4YHEA

Sep 10, 2019 · 112 followers View post →
Mustafa Yavuz
@Zuvayafatsum · X

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development https://t.co/19FKXFUaV8

Sep 8, 2019 · 2 likes · 361 followers View post →
mokgadi manabalala
@mokgadimanabala · X

RT @BrianRoemmele: Landmark research paper: In space clusters of nerve cells called mini-brains are developing in ways scientists didn’t t…

Sep 6, 2019 · 1 share · 536 followers View post →
Axion BioSystems
@axionbio1 · X

RT @CellStemCell: New Paper from Alysson Muotri's Lab @UCSDHealth: "Complex Oscillatory Waves Emerging from Cortical Organoids Model Early…

Sep 6, 2019 · 13 shares · 782 followers View post →
STEMCELL Technologies
@STEMCELLTech · X

RT @organoidscience: *NEW* in @CellStemCell from Dr. Alysson Muotri's lab at @UCSDMedSchool!

Sep 3, 2019 · 7 shares · 24,894 followers View post →
NeuroStemCells
@NeuroStemCell · X

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development. https://t.co/6cx97HoeSd @CellStemCell

Sep 3, 2019 · 1 like · 536 followers View post →
Epigenética
@Epigenetica · X

New in Pubmed: "Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development." https://t.co/VViqPjn5Ex

Sep 3, 2019 · 618 followers View post →
Rachel Hale
@rhale18 · X

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development https://t.co/7LyojFJJFv

Sep 3, 2019 · 406 followers View post →
Katherine Fairchild
@kvdmgallagher · X

RT @CellStemCell: New Paper from Alysson Muotri's Lab @UCSDHealth: "Complex Oscillatory Waves Emerging from Cortical Organoids Model Early…

Sep 2, 2019 · 13 shares · 59 followers View post →
Inti De La Rosa Velazquez
@IntiOmics · X

Cultivo de "#minicerebros" humanos, caracterización por #scRNAseq y actividad electrofisiológica en ellos! - Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development https://t.co/bU29vNcGiN

Sep 2, 2019 · 5 likes · 1,401 followers View post →
Raphaël Béné
@neuroraf · X

RT @introspection: Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development https://t.co/YksC…

Sep 2, 2019 · 5 shares · 3,281 followers View post →
lilKay
@kuffmode · X

RT @introspection: Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development https://t.co/YksC…

Sep 1, 2019 · 5 shares · 8,037 followers View post →
Micah G. Allen
@micahgallen · X

RT @introspection: Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development https://t.co/YksC…

Sep 1, 2019 · 5 shares · 23,145 followers View post →
Danilo Bzdok
@danilobzdok · X

RT @introspection: Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development https://t.co/YksC…

Sep 1, 2019 · 5 shares · 6,640 followers View post →
Rosaura Brisuela @roswitta.bsky.social
@Roswitamind · X

RT @introspection: Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development https://t.co/YksC…

Aug 31, 2019 · 5 shares · 1,285 followers View post →
Stefano Berto, PhD
@StefanoBerto83 · X

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development - ScienceDirect https://t.co/ChjPdPWdOy

Aug 31, 2019 · 2 likes · 7,716 followers View post →
Guillaume Dumas
@introspection · X

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development https://t.co/YksCvXb5Qv cc @DDinWonder https://t.co/w02ZtwSUv9

Aug 31, 2019 · 17 likes · 5 shares · 8,555 followers View post →
Yunhyong Kim
@YunhyongKim · X

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development https://t.co/TkwxWGO6Pn

Aug 31, 2019 · 345 followers View post →
Yangfei Xiang
@Yangfei_Lab · X

RT @CellStemCell: New Paper from Alysson Muotri's Lab @UCSDHealth: "Complex Oscillatory Waves Emerging from Cortical Organoids Model Early…

Aug 30, 2019 · 13 shares · 204 followers View post →
Paul Anastasiades
@P_Anastasiades · X

RT @neuroliege: Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development: Cell Stem… https://…

Aug 30, 2019 · 4 shares · 1,572 followers View post →
Firas D
@firasd · X

One of the issues I'm facing with summing up the daily science news is that I don't understand a lot of the items being recapped, lol. How can I even rephrase a paper titled "Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development"?

Aug 30, 2019 · 2,308 followers View post →
謙虚
@kenkyo3 · X

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development https://t.co/LQds9U1L3A

Aug 30, 2019 · 88 followers View post →
Anaclet Lab
@anaclet_lab · X

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development https://t.co/c80qDbqlYp

Aug 30, 2019 · 274 followers View post →
Kursad Turksen
@kursadturksen · X

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development - Scie https://t.co/6eeXaB38ab

Aug 30, 2019 · 1 like · 231 followers View post →
Tiago Fernandes
@TGF_fernandes · X

RT @CellStemCell: New Paper from Alysson Muotri's Lab @UCSDHealth: "Complex Oscillatory Waves Emerging from Cortical Organoids Model Early…

Aug 30, 2019 · 13 shares · 809 followers View post →
えばしゅう
@koburouze845 · X

>rt こりゃすごい Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development /Alysson R. Muotri 他https://t.co/EMpxh5ckoF

Aug 30, 2019 · 2,177 followers View post →
ぱんつ
@Fm7 · X

Cell Stem Cellのこの論文のことですかね・・・ Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development: Cell Stem Cell https://t.co/ySYBRuCxZf

Aug 30, 2019 · 3,035 followers View post →
ただ/だた (pinmarch)
@pinmarch_t · X

元論文これかね / Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development https://t.co/NFnoxbwnCP https://t.co/iiu9DLRp09

Aug 30, 2019 · 830 followers View post →
Matt Dubuc
@mjd1735 · X

RT @markomanka: Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development https://t.co/c6e4C4b…

Aug 29, 2019 · 1 share · 893 followers View post →
bird in sky
@birdinsky2 · X

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development: Cell Stem… https://t.co/GCrGBDxfwN

Aug 29, 2019 · 76 followers View post →
Dr Folu Oyefeso
@neuroenginerd · X

RT @organoidscience: *NEW* in @CellStemCell from Dr. Alysson Muotri's lab at @UCSDMedSchool!

Aug 29, 2019 · 7 shares · 646 followers View post →
Center for Epigenomics @ UC San Diego
@CEpigenomics · X

RT @CellStemCell: New Paper from Alysson Muotri's Lab @UCSDHealth: "Complex Oscillatory Waves Emerging from Cortical Organoids Model Early…

Aug 29, 2019 · 13 shares · 1,787 followers View post →
Angel Lizandro Polanco
@TheOrganoidBoy · X

RT @organoidscience: *NEW* in @CellStemCell from Dr. Alysson Muotri's lab at @UCSDMedSchool!

Aug 29, 2019 · 7 shares · 343 followers View post →
Dehorter Lab
@DehorterLab · X

RT @neuroliege: Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development: Cell Stem… https://…

Aug 29, 2019 · 4 shares · 1,292 followers View post →
Master Lectures On Stem Cells' Molecular Biology
@MastetB · X

RT @CellStemCell: New Paper from Alysson Muotri's Lab @UCSDHealth: "Complex Oscillatory Waves Emerging from Cortical Organoids Model Early…

Aug 29, 2019 · 13 shares · 60 followers View post →
Richard Hoopes
@hoopesrr · X

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development: Cell Stem Cell https://t.co/mSlqLPfJAT

Aug 29, 2019 · 20 followers View post →
Simona Lodato
@LodatoS_Lab · X

RT @neuroliege: Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development: Cell Stem… https://…

Aug 29, 2019 · 4 shares · 983 followers View post →
VirtualMarioArchila
@virtualmario · X

Can organoids exhibit complex oscillatory dynamics?

Aug 29, 2019 · 2 likes · 518 followers View post →
Rolando Lara
@Rol_andola · X

RT @CellStemCell: New Paper from Alysson Muotri's Lab @UCSDHealth: "Complex Oscillatory Waves Emerging from Cortical Organoids Model Early…

Aug 29, 2019 · 13 shares · 113 followers View post →
Laurent Nguyen
@neuroliege · X

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development: Cell Stem… https://t.co/HDj2Qm9seN

Aug 29, 2019 · 13 likes · 4 shares · 3,008 followers View post →
Dr. Aviseka
@aviseka · X

RT @CellStemCell: New Paper from Alysson Muotri's Lab @UCSDHealth: "Complex Oscillatory Waves Emerging from Cortical Organoids Model Early…

Aug 29, 2019 · 13 shares · 2,457 followers View post →
Eduardo Armienta
@eduardoarmienta · X

RT @topbiopapers: Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development https://t.co/Hnn7S…

Aug 29, 2019 · 1 share · 1,207 followers View post →
Trends in Molecular Medicine
@TrendsMolecMed · X

RT @CellStemCell: New Paper from Alysson Muotri's Lab @UCSDHealth: "Complex Oscillatory Waves Emerging from Cortical Organoids Model Early…

Aug 29, 2019 · 13 shares · 5,589 followers View post →
Jia Liu
@ganoopyliujia · X

RT @organoidscience: *NEW* in @CellStemCell from Dr. Alysson Muotri's lab at @UCSDMedSchool!

Aug 29, 2019 · 7 shares · 2,767 followers View post →
BrainOrganoid
@BOrganoid · X

RT @organoidscience: *NEW* in @CellStemCell from Dr. Alysson Muotri's lab at @UCSDMedSchool!

Aug 29, 2019 · 7 shares · 827 followers View post →
Organoid News
@organoidscience · X

*NEW* in @CellStemCell from Dr. Alysson Muotri's lab at @UCSDMedSchool!

Aug 29, 2019 · 13 likes · 7 shares · 13,795 followers View post →
Yossie
@GangFighterKy2 · X

RT @CellStemCell: New Paper from Alysson Muotri's Lab @UCSDHealth: "Complex Oscillatory Waves Emerging from Cortical Organoids Model Early…

Aug 29, 2019 · 13 shares · 156 followers View post →
BrainOrganoid
@BOrganoid · X

RT @CellStemCell: New Paper from Alysson Muotri's Lab @UCSDHealth: "Complex Oscillatory Waves Emerging from Cortical Organoids Model Early…

Aug 29, 2019 · 13 shares · 827 followers View post →
Cleber Trujillo
@trujillo_cleber · X

RT @CellStemCell: New Paper from Alysson Muotri's Lab @UCSDHealth: "Complex Oscillatory Waves Emerging from Cortical Organoids Model Early…

Aug 29, 2019 · 13 shares · 205 followers View post →
Chrystian Junqueira Alves
@SirChrystian · X

RT @CellStemCell: New Paper from Alysson Muotri's Lab @UCSDHealth: "Complex Oscillatory Waves Emerging from Cortical Organoids Model Early…

Aug 29, 2019 · 13 shares · 134 followers View post →
Cell Stem Cell
@CellStemCell · X

New Paper from Alysson Muotri's Lab @UCSDHealth: "Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development." Interpret w/caution; Organoids are NOT brains, they resemble some features useful for modeling https://t.co/ibJUVMWXVb https://t.co/feJoIN3sDU

Aug 29, 2019 · 26 likes · 13 shares · 58,415 followers View post →
Marco Manca
@markomanka · X

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development https://t.co/c6e4C4bVdi

Aug 29, 2019 · 1 like · 1 share · 1,580 followers View post →
topbiopapers
@topbiopapers · X

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development https://t.co/Hnn7SGc3ni

Aug 29, 2019 · 1 share · 354 followers View post →