Publications by authors named "Isaac Canals"

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Generation of iPSC Lines with Tagged α-Synuclein for Visualization of Endogenous Protein in Human Cellular Models of Neurodegenerative Disorders.
Oskar G Zetterdahl, James A Crowe, Samira Reyhani, Miriam A Güra, Ot Labastida-Botey, Isaac Canals

eNeuro· June 2025

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Aberrant neurodevelopment in human iPS cell-derived models of Alexander disease.
Zuzana Matusova, Werner Dykstra, Yolanda de Pablo, Oskar G Zetterdahl, Isaac Canals

Glia· January 2025

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Astrocyte dysfunction and neuronal network hyperactivity in a CRISPR engineered pluripotent stem cell model of frontotemporal dementia.
Isaac Canals, Andrea Comella-Bolla, Efrain Cepeda-Prado, Natalia Avaliani, James A Crowe

Brain Commun· May 2023

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Transcription Factor-Forced Astrocytic Differentiation Impairs Human Glioblastoma Growth In Vitro and In Vivo.
Francesco Trovato, Francesca Romana Stefani, Jiaxin Li, Oskar G Zetterdahl, Isaac Canals

Mol Cancer Ther· February 2023

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FOXO1 regulates pentose phosphate pathway-mediated induction of developmental erythropoiesis.
Anuntxi Monsalve, Isaac Canals, Leal Oburoglu

Front Cell Dev Biol· October 2022

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Genome Editing Using Cas9-gRNA Ribonucleoprotein in Human Pluripotent Stem Cells for Disease Modeling.
Noelia Benetó, Daniel Grinberg, Lluïsa Vilageliu, Isaac Canals

Methods Mol Biol· July 2022

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Transcription factor-based direct conversion of human fibroblasts to functional astrocytes.
Ella Quist, Francesco Trovato, Natalia Avaliani, Oskar G Zetterdahl, Ana Gonzalez-Ramos, Isaac Canals

Stem Cell Reports· July 2022

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Pyruvate metabolism guides definitive lineage specification during hematopoietic emergence.
Leal Oburoglu, Els Mansell, Isaac Canals, Valgardur Sigurdsson, Carolina Guibentif

EMBO Rep· February 2022

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Transcription Factor Programming of Human Pluripotent Stem Cells to Functionally Mature Astrocytes for Monocultures and Cocultures with Neurons.
Ella Quist, Henrik Ahlenius, Isaac Canals

Methods Mol Biol· August 2021

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CRISPR/Cas9 Genome Engineering in Human Pluripotent Stem Cells for Modeling of Neurological Disorders.
Isaac Canals, Henrik Ahlenius

Methods Mol Biol· August 2021

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Transcription Factor-Based Strategies to Generate Neural Cell Types from Human Pluripotent Stem Cells.
Isaac Canals, Ella Quist, Henrik Ahlenius

Cell Reprogram· August 2021

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mmRNA-Based Transcriptional Programming in Microfluidic Guides hiPSCs Toward Neural Fate With Multiple Identities.
Anna Maria Tolomeo, Cecilia Laterza, Eleonora Grespan, Federica Michielin, Isaac Canals

Front Cell Neurosci· February 2021

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Sanfilippo Syndrome: Molecular Basis, Disease Models and Therapeutic Approaches.
Noelia Benetó, Lluïsa Vilageliu, Daniel Grinberg, Isaac Canals

Int J Mol Sci· October 2020

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Mitochondrial Dysfunction and Calcium Dysregulation in Leigh Syndrome Induced Pluripotent Stem Cell Derived Neurons.
Teresa Galera-Monge, Francisco Zurita-Díaz, Isaac Canals, Marita Grønning Hansen, Laura Rufián-Vázquez

Int J Mol Sci· April 2020

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Neuronal and Astrocytic Differentiation from Sanfilippo C Syndrome iPSCs for Disease Modeling and Drug Development.
Noelia Benetó, Monica Cozar, Laura Castilla-Vallmanya, Oskar G Zetterdahl, Madalina Sacultanu, Isaac Canals

J Clin Med· February 2020

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Generation of two NAGLU-mutated homozygous cell lines from healthy induced pluripotent stem cells using CRISPR/Cas9 to model Sanfilippo B syndrome.
Noelia Benetó, Monica Cozar, Laura Gort, Laura Pacheco, Lluïsa Vilageliu, Isaac Canals

Stem Cell Res· January 2020

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Generation of two compound heterozygous HGSNAT-mutated lines from healthy induced pluripotent stem cells using CRISPR/Cas9 to model Sanfilippo C syndrome.
Noelia Benetó, Monica Cozar, María García-Morant, Edgar Creus-Bachiller, Lluïsa Vilageliu, Isaac Canals

Stem Cell Res· December 2019

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In Vitro Functional Characterization of Human Neurons and Astrocytes Using Calcium Imaging and Electrophysiology.
Marita Grønning Hansen, Daniel Tornero, Isaac Canals, Henrik Ahlenius, Zaal Kokaia

Methods Mol Biol· June 2019

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Author Correction: Rapid and efficient induction of functional astrocytes from human pluripotent stem cells.
Isaac Canals, Aurélie Ginisty, Ella Quist, Raissa Timmerman, Jonas Fritze

Nat Methods· January 2019

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Rapid and efficient induction of functional astrocytes from human pluripotent stem cells.
Isaac Canals, Aurélie Ginisty, Ella Quist, Raissa Timmerman, Jonas Fritze

Nat Methods· September 2018

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Activity and High-Order Effective Connectivity Alterations in Sanfilippo C Patient-Specific Neuronal Networks.
Isaac Canals, Jordi Soriano, Javier G Orlandi, Roger Torrent, Yvonne Richaud-Patin

Stem Cell Reports· October 2015

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EXTL2 and EXTL3 inhibition with siRNAs as a promising substrate reduction therapy for Sanfilippo C syndrome.
Isaac Canals, Noelia Benetó, Mónica Cozar, Lluïsa Vilageliu, Daniel Grinberg

Sci Rep· September 2015

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Therapeutic strategies based on modified U1 snRNAs and chaperones for Sanfilippo C splicing mutations.
Liliana Matos, Isaac Canals, Larbi Dridi, Yoo Choi, Maria João Prata

Orphanet J Rare Dis· December 2014

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