Publications by authors named "Isabel Leung"

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Compromised antigen binding and signaling interfere with bispecific CD19 and CD79a chimeric antigen receptor function.
Isabel Leung, Megan L Templeton, Yun Lo, Anusha Rajan, Sylvia M Stull

Blood Adv· June 2023

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A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy.
Alfredo Quijano-Rubio, Aladdin M Bhuiyan, Huilin Yang, Isabel Leung, Elisa Bello

Nat Biotechnol· April 2023

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NOTCH1 signaling during CD4+ T-cell activation alters transcription factor networks and enhances antigen responsiveness.
Alec B Wilkens, Elena C Fulton, Margot J Pont, Gabriel O Cole, Isabel Leung

Blood· November 2022

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Comparative analysis of TCR and CAR signaling informs CAR designs with superior antigen sensitivity and in vivo function.
Alexander I Salter, Anusha Rajan, Jacob J Kennedy, Richard G Ivey, Sarah A Shelby, Isabel Leung

Sci Signal· August 2021

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De novo design of potent and selective mimics of IL-2 and IL-15.
Daniel-Adriano Silva, Shawn Yu, Umut Y Ulge, Jamie B Spangler, Kevin M Jude, Isabel Leung

Nature· January 2019

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A Highly Diverse and Functional Naïve Ubiquitin Variant Library for Generation of Intracellular Affinity Reagents.
Isabel Leung, Nick Jarvik, Sachdev S Sidhu

J Mol Biol· January 2017

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Saturation scanning of ubiquitin variants reveals a common hot spot for binding to USP2 and USP21.
Isabel Leung, Ayelet Dekel, Julia M Shifman, Sachdev S Sidhu

Proc Natl Acad Sci U S A· August 2016

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