Publications by authors named "Isabel Ramis"

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The pan-JAK inhibitor LAS194046 reduces neutrophil activation from severe asthma and COPD patients in vitro.
Javier Milara, Beatriz Ballester, Alfredo de Diego, Marta Calbet, Isabel Ramis

Sci Rep· March 2022

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Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases.
Jordi Bach, Paul Eastwood, Jacob González, Elena Gómez, Juan Antonio Alonso, Isabel Ramis

J Med Chem· October 2019

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Novel Inhaled Pan-JAK Inhibitor, LAS194046, Reduces Allergen-Induced Airway Inflammation, Late Asthmatic Response, and pSTAT Activation in Brown Norway Rats.
Marta Calbet, Isabel Ramis, Elena Calama, Cristina Carreño, Stephane Paris

J Pharmacol Exp Ther· August 2019

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PI3K, p38 and JAK/STAT signalling in bronchial tissue from patients with asthma following allergen challenge.
Thomas Southworth, Sarah Mason, Alan Bell, Isabel Ramis, Marta Calbet

Biomark Res· April 2018

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Tofacitinib ameliorates inflammation in a rat model of airway neutrophilia induced by inhaled LPS.
Elena Calama, Isabel Ramis, Anna Domènech, Cristina Carreño, Jorge De Alba

Pulm Pharmacol Ther· April 2017

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Anti-inflammatory potential of PI3Kδ and JAK inhibitors in asthma patients.
Thomas Southworth, Jonathan Plumb, Vandana Gupta, James Pearson, Isabel Ramis

Respir Res· October 2016

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A novel inhaled Syk inhibitor blocks mast cell degranulation and early asthmatic response.
Isabel Ramis, Raquel Otal, Cristina Carreño, Anna Domènech, Peter Eichhorn

Pharmacol Res· September 2015

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Highly potent aminopyridines as Syk kinase inhibitors.
Marcos Castillo, Pilar Forns, Montse Erra, Marta Mir, Manel López, Isabel Ramis

Bioorg Med Chem Lett· September 2012

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Pyrazine-based Syk kinase inhibitors.
Pilar Forns, Cristina Esteve, Lorena Taboada, Juan Antonio Alonso, Adelina Orellana, Isabel Ramis

Bioorg Med Chem Lett· April 2012

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Characterization of a model of tracheal plasma extravasation in passively sensitized rats using anti-allergic and anti-inflammatory drugs by oral and intratracheal route.
Cristina Carreño, Anna Domènech, Neus Prats, Montserrat Miralpeix, Isabel Ramis

Pulm Pharmacol Ther· February 2012

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The new salicylate derivative UR-1505 modulates the Th2/humoral response in a dextran sodium sulphate model of colitis that resembles ulcerative colitis.
Elvira Bailón, Juan Román, Isabel Ramis, Pedro Michelena, Dolors Balsa

J Pharmacol Sci· February 2009

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UR-1505, a salicylate able to selectively block T-cell activation, shows intestinal anti-inflammatory activity in the chronic phase of the DSS model of rat colitis.
Elvira Bailón, Mònica Comalada, Juan Román, Pedro Michelena, Isabel Ramis

Inflamm Bowel Dis· July 2008

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The intestinal anti-inflammatory effects of the novel agent UR-1505 in the TNBS model of rat colitis are mediated by T-lymphocyte inhibition.
Elvira Bailón, Desirée Camuesco, Ana Nieto, Angel Concha, Alberto Fernández de Arriba, Isabel Ramis

Biochem Pharmacol· November 2007

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UR-1505, a new salicylate, blocks T cell activation through nuclear factor of activated T cells.
Juan Román, Alberto Fernández de Arriba, Sonia Barrón, Pedro Michelena, Marta Giral, Isabel Ramis

Mol Pharmacol· August 2007

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New water-soluble sulfonylphosphoramidic acid derivatives of the COX-2 selective inhibitor cimicoxib. A novel approach to sulfonamide prodrugs.
Carmen Almansa, Javier Bartrolí, Jordi Belloc, Fernando L Cavalcanti, Rosa Ferrando, Isabel Ramis

J Med Chem· October 2004

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The intestinal anti-inflammatory activity of UR-12746S on reactivated experimental colitis is mediated through downregulation of cytokine production.
Julio Gálvez, Margarita Garrido, Maria Elena Rodríguez-Cabezas, Isabel Ramis, Fermín Sánchez de Medina

Inflamm Bowel Dis· November 2003

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