Publications by authors named "Isabelle Duplan"

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Insulin-degrading enzyme inhibition increases the unfolded protein response and favours lipid accumulation in the liver.
Marine Andres, Nathalie Hennuyer, Khamis Zibar, Marie Bicharel-Leconte, Isabelle Duplan

Br J Pharmacol· October 2024

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Benzopyran hydrazones with dual PPARα/γ or PPARα/δ agonism and an anti-inflammatory effect on human THP-1 macrophages.
Ainhoa García, Laura Vila, Isabelle Duplan, María Ayelén Schiel, Ricardo D Enriz

Eur J Med Chem· February 2024

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Discovery, Structure-Activity Relationships, and In Vivo Activity of Dihydropyridone Agonists of the Bile Acid Receptor TGR5.
Sylvain Picon, Rajaa Boulahjar, Vanessa Hoguet, Morgane Baron, Isabelle Duplan

J Med Chem· September 2023

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Anti-inflammatory effects and improved metabolic derangements in ob/ob mice by a newly synthesized prenylated benzopyran with pan-PPAR activity.
Patrice Marques, Carlos Villarroel-Vicente, Aida Collado, Ainhoa García, Laura Vila, Isabelle Duplan

Pharmacol Res· January 2023

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Identification of indole-based activators of insulin degrading enzyme.
Nicolas Kraupner, Chau Phi Dinh, Xiaoan Wen, Valérie Landry, Adrien Herledan, Isabelle Duplan

Eur J Med Chem· January 2022

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Beyond the Rule of 5: Impact of PEGylation with Various Polymer Sizes on Pharmacokinetic Properties, Structure-Properties Relationships of mPEGylated Small Agonists of TGR5 Receptor.
Vanessa Hoguet, Manuel Lasalle, Mathieu Maingot, Geoffroy Dequirez, Rajaa Boulahjar, Isabelle Duplan

J Med Chem· February 2021

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Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance.
Manuel Lasalle, Vanessa Hoguet, Nathalie Hennuyer, Florence Leroux, Catherine Piveteau, Isabelle Duplan

J Med Chem· May 2017

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DHA-derived oxylipins, neuroprostanes and protectins, differentially and dose-dependently modulate the inflammatory response in human macrophages: Putative mechanisms through PPAR activation.
Rémy Bosviel, Laurie Joumard-Cubizolles, Giulia Chinetti-Gbaguidi, Dominique Bayle, Corinne Copin, Isabelle Duplan

Free Radic Biol Med· February 2017

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The novel selective PPARα modulator (SPPARMα) pemafibrate improves dyslipidemia, enhances reverse cholesterol transport and decreases inflammation and atherosclerosis.
Nathalie Hennuyer, Isabelle Duplan, Charlotte Paquet, Jonathan Vanhoutte, Eloise Woitrain

Atherosclerosis· June 2016

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Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Rebecca Deprez-Poulain, Nathalie Hennuyer, Damien Bosc, Wenguang G Liang, Emmanuelle Enée, Isabelle Duplan

Nat Commun· September 2015

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The human hepatocyte cell lines IHH and HepaRG: models to study glucose, lipid and lipoprotein metabolism.
Carolina Huaman Samanez, Sandrine Caron, Olivier Briand, Hélène Dehondt, Isabelle Duplan

Arch Physiol Biochem· July 2012

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