Publications by authors named "Isabelle Heit"

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Optimisation of ITK inhibitors through successive iterative design cycles.
Matthias Herdemann, Alexander Weber, Jérôme Jonveaux, Frank Schwoebel, Michael Stoeck, Isabelle Heit

Bioorg Med Chem Lett· March 2011

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Identification of potent ITK inhibitors through focused compound library design including structural information.
Matthias Herdemann, Isabelle Heit, Frank-Uwe Bosch, Gianluca Quintini, Claudia Scheipers

Bioorg Med Chem Lett· December 2010

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Synthesis and biological evaluation of novel (4 or 5-aryl)pyrazolyl-indoles as inhibitors of interleukin-2 inducible T-cell kinase (ITK).
Avdhoot D Velankar, Gianluca Quintini, Arati Prabhu, Alexander Weber, Gundula Hunaeus, Isabelle Heit

Bioorg Med Chem· June 2010

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PKCtheta and Itk functionally interact during primary mouse CD3+ T cell activation.
Nikolaus Thuille, Christina Lutz-Nicoladoni, Thomas Letschka, Natascha Hermann-Kleiter, Isabelle Heit

Immunol Lett· September 2009

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Comment on "PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation".
Thomas Gruber, Michael Freeley, Nikolaus Thuille, Isabelle Heit, Stephen Shaw

Science· April 2006

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Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCtheta in T lymphocytes.
Nikolaus Thuille, Isabelle Heit, Friedrich Fresser, Nina Krumböck, Birgit Bauer

EMBO J· November 2005

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