Publications by authors named "Isabelle Krimm"

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Picomolar bivalent inhibitors of protein kinase CK2 active against β-coronavirus replication.
Dylan Grenier, Dennis Salomon Lopez Molina, Muriel Gelin, Angélique Mularoni, Jean-François Guichou, Isabelle Krimm

Eur J Med Chem· October 2025

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Development of ultra-miniaturized weak affinity chromatography coupled to mass spectrometry as a high throughput fragment screening method against wild-type and purified membrane proteins embedded in biomimetic membranes.
François-Xavier Vidal, Julie Gil, Maud Gregson, Gabrielle Zeder-Lutz, Maria Hideux, Isabelle Krimm

Anal Chim Acta· June 2025

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Rational Design and Synthesis of Highly Stable Haloflavanone DNA Methyltransferase Inhibitors Inducing Tumor Suppressor Gene Re-expression in Cancer Cells.
Francesco Calzaferri, Hiba Daher, Julie Gilbert, Yinshan Yang, Marine Tauziet, Isabelle Krimm

J Med Chem· June 2025

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Discovery of KDX1381, a Bivalent CK2α Inhibitor for the Treatment of Solid Tumors as a Single Agent or in Combination.
Léna Marlhoux, Alexandre Arnaud, Céline Hervieu, Gabriela Makulyte, Charlotte Martinasso, Isabelle Krimm

J Med Chem· June 2025

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Binding-Site Switch for Protein Kinase CK2 Inhibitors.
Dylan Grenier, Muriel Gelin, Yinshan Yang, Angélique Mularoni, Jean-François Guichou, Isabelle Krimm

ChemMedChem· April 2025

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Development of Fragment-Based Inhibitors of the Bacterial Deacetylase LpxC with Low Nanomolar Activity.
Sebastian Mielniczuk, Katharina Hoff, Fady Baselious, Yunqi Li, Jörg Haupenthal, Isabelle Krimm

J Med Chem· October 2024

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Cancer selective cell death induction by a bivalent CK2 inhibitor targeting the ATP site and the allosteric αD pocket.
Alexandre Bancet, Rita Frem, Florian Jeanneret, Angélique Mularoni, Pauline Bazelle, Isabelle Krimm

iScience· February 2024

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Combining nano-differential scanning fluorimetry and microscale thermophoresis to investigate VDAC1 interaction with small molecules.
Hubert Gorny, Angélique Mularoni, Jean-Guy Delcros, Céline Freton, Jordane Preto, Isabelle Krimm

J Enzyme Inhib Med Chem· December 2023

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Linkers in fragment-based drug design: an overview of the literature.
Dylan Grenier, Solène Audebert, Jordane Preto, Jean-François Guichou, Isabelle Krimm

Expert Opin Drug Discov· November 2023

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Preparation of miniaturized hydrophilic affinity monoliths: Towards a reduction of non-specific interactions and an increased target protein density.
Julie Gil, Isabelle Krimm, Vincent Dugas, Claire Demesmay

J Chromatogr A· January 2023

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A fragment-based drug discovery strategy applied to the identification of NDM-1 β-lactamase inhibitors.
Jérémy Caburet, Benjamin Boucherle, Sofiane Bourdillon, Giorgia Simoncelli, Federica Verdirosa, Isabelle Krimm

Eur J Med Chem· October 2022

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A Deep Dive into VDAC1 Conformational Diversity Using All-Atom Simulations Provides New Insights into the Structural Origin of the Closed States.
Jordane Preto, Hubert Gorny, Isabelle Krimm

Int J Mol Sci· January 2022

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The intrinsically disordered N-terminus of the voltage-dependent anion channel.
Jordane Preto, Isabelle Krimm

PLoS Comput Biol· February 2021

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Fragment Linking Strategies for Structure-Based Drug Design.
Alexandre Bancet, Claire Raingeval, Thierry Lomberget, Marc Le Borgne, Jean-François Guichou, Isabelle Krimm

J Med Chem· October 2020

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Synthesis, Optimization, Antifungal Activity, Selectivity, and CYP51 Binding of New 2-Aryl-3-azolyl-1-indolyl-propan-2-ols.
Nicolas Lebouvier, Fabrice Pagniez, Young Min Na, Da Shi, Patricia Pinson, Isabelle Krimm

Pharmaceuticals (Basel)· August 2020

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Miniaturized weak affinity chromatography for ligand identification of nanodiscs-embedded G-protein coupled receptors.
Lucile Lecas, Lucie Hartmann, Lydia Caro, Sarah Mohamed-Bouteben, Claire Raingeval, Isabelle Krimm

Anal Chim Acta· May 2020

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1D NMR WaterLOGSY as an efficient method for fragment-based lead discovery.
Claire Raingeval, Olivier Cala, Béatrice Brion, Marc Le Borgne, Roderick Eliot Hubbard, Isabelle Krimm

J Enzyme Inhib Med Chem· December 2019

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Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors.
Irina Kufareva, Benoit Bestgen, Paul Brear, Renaud Prudent, Béatrice Laudet, Isabelle Krimm

Sci Rep· November 2019

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NMR investigation of protein-ligand interactions for G-protein coupled receptors.
Claire Raingeval, Isabelle Krimm

Future Med Chem· July 2019

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Modification and Biological Evaluation of a Series of 1,5-Diaryl-1,2,4-triazole Compounds as Novel Agents against Pancreatic Cancer Metastasis through Targeting Myoferlin.
Yunqi Li, Yuan He, Ting Shao, Haixiang Pei, Weikai Guo, Isabelle Krimm

J Med Chem· May 2019

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2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 1. Identification of an Allosteric Binding Site.
Benoît Bestgen, Isabelle Krimm, Irina Kufareva, Ahmed Ashraf Moustafa Kamal, Wei-Guang Seetoh

J Med Chem· February 2019

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Enabling STD-NMR fragment screening using stabilized native GPCR: A case study of adenosine receptor.
Sébastien Igonet, Claire Raingeval, Erika Cecon, Maja Pučić-Baković, Gordan Lauc, Isabelle Krimm

Sci Rep· May 2018

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Identifying Protein Allosteric Transitions for Drug Discovery with 1D NMR.
Isabelle Krimm

ChemMedChem· June 2017

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Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities.
Abdelhakim Ahmed-Belkacem, Lionel Colliandre, Nazim Ahnou, Quentin Nevers, Muriel Gelin, Isabelle Krimm

Nat Commun· September 2016

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Identification of Noncompetitive Inhibitors of Cytosolic 5'-Nucleotidase II Using a Fragment-Based Approach.
Zsuzsanna Marton, Rémi Guillon, Isabelle Krimm, Preeti, Rahila Rahimova

J Med Chem· December 2015

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