Publications by authors named "Isabelle Landrieu"

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Anti-tau VHH therapy against PHF6: a safe approach to slowing the phenotype of tau pathology.
Raphaelle Caillierez, Clémence Leboullenger, Sarah Leclercq, Mélanie Besegher, Séverine Bégard, Isabelle Landrieu

Alzheimers Res Ther· October 2025

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BIN1 and Alzheimer's disease: the tau connection.
Pierre Dourlen, Devrim Kilinc, Isabelle Landrieu, Julien Chapuis, Jean-Charles Lambert

Trends Neurosci· May 2025

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Conformation-Driven Phase Separation in the Linker Domain of Focal Adhesion Kinases.
Lucy Martin, Daniela P Freitas, Emmanuelle Boll, Alain Brans, Justine Mortelecque, Isabelle Landrieu

Biochemistry· April 2025

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Inhibition of tau neuronal internalization using anti-tau single domain antibodies.
Clément Danis, Elian Dupré, Thomas Bouillet, Marine Denéchaud, Camille Lefebvre, Isabelle Landrieu

Nat Commun· April 2025

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Effect of PHF-1 hyperphosphorylation on the seeding activity of C-terminal Tau fragments.
Léa El Hajjar, Emmanuelle Boll, François-Xavier Cantrelle, Clarisse Bridot, Isabelle Landrieu

Sci Rep· March 2025

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Fragment-Based Interrogation of the 14-3-3/TAZ Protein-Protein Interaction.
Blaž Andlovic, Dario Valenti, Federica Centorrino, Francesca Picarazzi, Stanimira Hristeva, Isabelle Landrieu

Biochemistry· September 2024

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Aggregate-selective removal of pathological tau by clustering-activated degraders.
Jonathan Benn, Shi Cheng, Sophie Keeling, Annabel E Smith, Marina J Vaysburd, Isabelle Landrieu

Science· August 2024

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Regulation of Glycogen Synthase Kinase-3β by Phosphorylation and O-β-Linked N-Acetylglucosaminylation: Implications on Tau Protein Phosphorylation.
Léa El Hajjar, Adeline Page, Clarisse Bridot, François-Xavier Cantrelle, Isabelle Landrieu

Biochemistry· June 2024

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Development of Receptor for Advanced Glycation End Products (RAGE) ligands through target directed dynamic combinatorial chemistry: a novel class of possible antagonists.
Anca-Elena Dascalu, Christophe Furman, Isabelle Landrieu, François-Xavier Cantrelle, Justine Mortelecque

Chemistry· April 2024

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A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the tau intrinsically disordered protein.
Justine Mortelecque, Orgeta Zejneli, Séverine Bégard, Margarida C Simões, Lea ElHajjar, Isabelle Landrieu

J Biol Chem· April 2024

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Precision proteoform design for 4R tau isoform selective templated aggregation.
Andrew P Longhini, Austin DuBose, Samuel Lobo, Vishnu Vijayan, Yeran Bai, Isabelle Landrieu

Proc Natl Acad Sci U S A· April 2024

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Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models.
Neha Basheer, Luc Buee, Jean-Pierre Brion, Tomas Smolek, Muhammad Khalid Muhammadi, Isabelle Landrieu

Acta Neuropathol Commun· April 2024

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Recombinant Production and Characterization of VHHs/Nanobodies Targeting Tau to Block Fibrillar Assembly.
Justine Mortelecque, Clément Danis, Isabelle Landrieu, Elian Dupré

Methods Mol Biol· March 2024

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The O-GlcNAc Modification of Recombinant Tau Protein and Characterization of the O-GlcNAc Pattern for Functional Study.
Léa El Hajjar, Clarisse Bridot, Marine Nguyen, François-Xavier Cantrelle, Isabelle Landrieu

Methods Mol Biol· March 2024

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Phosphorylation of Tau Protein by CDK2/cyclin A and GSK3β Recombinant Kinases: Analysis of Phosphorylation Patterns by Nuclear Magnetic Resonance Spectroscopy.
Léa El Hajjar, Clarisse Bridot, Marine Nguyen, François-Xavier Cantrelle, Isabelle Landrieu

Methods Mol Biol· March 2024

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Magnetic resonance investigation of conformational responses of tau protein to specific phosphorylation.
Alessia Lasorsa, Hamida Merzougui, François-Xavier Cantrelle, Giuseppe Sicoli, Elian Dupré, Isabelle Landrieu

Biophys Chem· February 2024

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Precision Proteoform Design for 4R Tau Isoform Selective Templated Aggregation.
Andrew P Longhini, Austin DuBose, Samuel Lobo, Vishnu Vijayan, Yeran Bai, Isabelle Landrieu

bioRxiv· November 2023

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Conformation and Affinity Modulations by Multiple Phosphorylation Occurring in the BIN1 SH3 Domain Binding Site of the Tau Protein Proline-Rich Region.
Alessia Lasorsa, Krishnendu Bera, Idir Malki, Elian Dupré, François-Xavier Cantrelle, Isabelle Landrieu

Biochemistry· June 2023

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Deciphering the Structure and Formation of Amyloids in Neurodegenerative Diseases With Chemical Biology Tools.
Isabelle Landrieu, Elian Dupré, Davy Sinnaeve, Léa El Hajjar, Caroline Smet-Nocca

Front Chem· May 2022

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Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment.
Clément Danis, Elian Dupré, Orgeta Zejneli, Raphaëlle Caillierez, Alexis Arrial, Isabelle Landrieu

Mol Ther· April 2022

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NMR Spectroscopy of the Main Protease of SARS-CoV-2 and Fragment-Based Screening Identify Three Protein Hotspots and an Antiviral Fragment.
François-Xavier Cantrelle, Emmanuelle Boll, Lucile Brier, Danai Moschidi, Sandrine Belouzard, Isabelle Landrieu

Angew Chem Int Ed Engl· November 2021

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Dynamic interactions and Ca-binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding.
Guilherme G Moreira, François-Xavier Cantrelle, Andrea Quezada, Filipa S Carvalho, Joana S Cristóvão, Isabelle Landrieu

Nat Commun· November 2021

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Phosphorylation and -GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates.
François-Xavier Cantrelle, Anne Loyens, Xavier Trivelli, Oliver Reimann, Clément Despres, Isabelle Landrieu

Front Mol Neurosci· June 2021

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Phosphorylated full-length Tau interacts with 14-3-3 proteins via two short phosphorylated sequences, each occupying a binding groove of 14-3-3 dimer.
João Filipe Neves, Olivia Petrvalská, Francesco Bosica, François-Xavier Cantrelle, Hamida Merzougui, Isabelle Landrieu

FEBS J· March 2021

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Fragment-based Differential Targeting of PPI Stabilizer Interfaces.
Xavier Guillory, Madita Wolter, Seppe Leysen, João Filipe Neves, Ave Kuusk, Isabelle Landrieu

J Med Chem· July 2020

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