Publications by authors named "Isak Im"

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25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome.
Jiho Jang, Sangjun Park, Hye Jin Hur, Hyun-Ju Cho, Inhwa Hwang, Isak Im, Dong-Wook Kim

Nat Commun· October 2016

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Dual small-molecule targeting of procaspase-3 dramatically enhances zymogen activation and anticancer activity.
Rachel C Botham, Timothy M Fan, Isak Im, Luke B Borst, Levent Dirikolu

J Am Chem Soc· January 2014

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FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease.
Tae-In Kam, Sungmin Song, Youngdae Gwon, Hyejin Park, Ji-Jing Yan, Isak Im, Jeongyeon Kim, Yong-Chul Kim, Key-Sun Kim

J Clin Invest· July 2013

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Identification of a novel protein synthesis inhibitor active against gram-positive bacteria.
Nora R Eibergen, Isak Im, Nisha Y Patel, Paul J Hergenrother

Chembiochem· March 2012

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Design, synthesis and X-ray crystallographic study of NAmPRTase inhibitors as anti-cancer agents.
Hyun You, Hyung-Seop Youn, Isak Im, Man-Ho Bae, Sang-Kook Lee, Yong-Chul Kim

Eur J Med Chem· April 2011

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Design and synthesis of 1,4-dihydropyridine derivatives as BACE-1 inhibitors.
Soo-Jeong Choi, Joong-Heui Cho, Isak Im, So-Deok Lee, Ji-Yeon Jang, Yong-Chul Kim

Eur J Med Chem· June 2010

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5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity.
Soo-Jeong Choi, Jung-Eun Lee, Soon-Young Jeong, Isak Im, So-Deok Lee, Jae-Il Kim, Yong-Chul Kim

J Med Chem· May 2010

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Structure-activity relationships of heteroaromatic esters as human rhinovirus 3C protease inhibitors.
Isak Im, Eui Seung Lee, Soo Jeong Choi, Ju-Yeon Lee, Yong-Chul Kim

Bioorg Med Chem Lett· July 2009

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Combinatorial synthesis and biological evaluation of peptide-binding GPCR-targeted library.
Ju Yeon Lee, Isak Im, Thomas R Webb, Douglas McGrath, Mi-Ryoung Song, Yong-Chul Kim

Bioorg Chem· June 2009

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Crystal structure of Rattus norvegicus Visfatin/PBEF/Nampt in complex with an FK866-based inhibitor.
Gil Bu Kang, Man-Ho Bae, Mun-Kyoung Kim, Isak Im, Yong-Chul Kim

Mol Cells· June 2009

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Development of potent inhibitors of the coxsackievirus 3C protease.
Eui Seung Lee, Won Gil Lee, Soo-Hyeon Yun, Seong Hwan Rho, Isak Im, Yong-Chul Kim

Biochem Biophys Res Commun· June 2007

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Benzofuroindole analogues as potent BK(Ca) channel openers.
Ahmet E Gormemis, Tal Soo Ha, Isak Im, Kwan-Young Jung, Ju Yeon Lee, Yong-Chul Kim

Chembiochem· October 2005

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Structure-based virtual screening and biological evaluation of potent and selective ADAM12 inhibitors.
Myungsok Oh, Isak Im, Yong Jae Lee, Young Hoon Kim, Jeong Hyeok Yoon, Yong-Chul Kim

Bioorg Med Chem Lett· December 2004

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Solid-phase synthesis of tetrahydro-1,4-benzodiazepine-2-one derivatives as a beta-turn peptidomimetic library.
Isak Im, Thomas R Webb, Young-Dae Gong, Jae-Il Kim, Yong-Chul Kim

J Comb Chem· May 2004

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