Publications by authors named "Isak W Tengesdal"

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Clonal Hematopoiesis in Nonmalignant Disease: Functional Consequences of Mutated Immune Cells by Clonal Hematopoiesis in the Diseased Tissue.
Youngil Koh, Isak W Tengesdal, Siddhartha Jaiswal

Annu Rev Pathol· September 2025

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Mutant macrophages CHIP in to help solid tumors.
Isak W Tengesdal, Siddhartha Jaiswal

Cell· May 2025

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Screening NLRP3 drug candidates in clinical development: lessons from existing and emerging technologies.
Isak W Tengesdal, Migachelle Banks, Charles A Dinarello, Carlo Marchetti

Front Immunol· August 2024

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International nomenclature guidelines for the IL-1 family of cytokines and receptors.
Joseph M Gaballa, Jesper Falkesgaard Højen, Dennis M De Graaf, Jesus Amo-Aparicio, Carlo Marchetti, Isak W Tengesdal

Nat Immunol· April 2024

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NLRP3 and cancer: Pathogenesis and therapeutic opportunities.
Isak W Tengesdal, Charles A Dinarello, Carlo Marchetti

Pharmacol Ther· November 2023

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Dexamethasone and OLT1177 Cooperate in the Reduction of Melanoma Growth by Inhibiting STAT3 Functions.
Alberto Dinarello, Taylor S Mills, Isak W Tengesdal, Nicholas E Powers, Tania Azam

Cells· January 2023

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IL-38 Gene Deletion Worsens Murine Colitis.
Dennis M de Graaf, Ruth X Wang, Jesús Amo-Aparicio, J Scott Lee, Alexander S Dowdell, Isak W Tengesdal

Front Immunol· June 2022

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Activation of Host-NLRP3 Inflammasome in Myeloid Cells Dictates Response to Anti-PD-1 Therapy in Metastatic Breast Cancers.
Isak W Tengesdal, Suzhao Li, Nicholas E Powers, Makenna May, Charles P Neff

Pharmaceuticals (Basel)· May 2022

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Oncogene-induced maladaptive activation of trained immunity in the pathogenesis and treatment of Erdheim-Chester disease.
Raffaella Molteni, Riccardo Biavasco, Davide Stefanoni, Travis Nemkov, Jorge Domínguez-Andrés, Isak W Tengesdal

Blood· October 2021

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Tumor NLRP3-Derived IL-1β Drives the IL-6/STAT3 Axis Resulting in Sustained MDSC-Mediated Immunosuppression.
Isak W Tengesdal, Alberto Dinarello, Nicholas E Powers, Matthew A Burchill, Leo A B Joosten

Front Immunol· October 2021

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The anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity.
Giulio Cavalli, Isak W Tengesdal, Mark Gresnigt, Travis Nemkov, Rob J W Arts

Cell Rep· April 2021

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Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion.
Isak W Tengesdal, Dinoop R Menon, Douglas G Osborne, Charles P Neff, Nicholas E Powers

Proc Natl Acad Sci U S A· March 2021

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Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial.
Viola Klück, Tim L Th A Jansen, Matthijs Janssen, Antoaneta Comarniceanu, Monique Efdé, Isak W Tengesdal

Lancet Rheumatol· May 2020

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Role for nuclear interleukin-37 in the suppression of innate immunity.
Suzhao Li, Jesus Amo-Aparicio, Charles P Neff, Isak W Tengesdal, Tania Azam

Proc Natl Acad Sci U S A· March 2019

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The selective ROCK2 inhibitor KD025 reduces IL-17 secretion in human peripheral blood mononuclear cells independent of IL-1 and IL-6.
Isak W Tengesdal, David Kitzenberg, Suzhao Li, Melanie S Nyuydzefe, Wei Chen

Eur J Immunol· October 2018

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Interleukin-37 treatment of mice with metabolic syndrome improves insulin sensitivity and reduces pro-inflammatory cytokine production in adipose tissue.
Dov B Ballak, Suzhao Li, Giulio Cavalli, Jonathan L Stahl, Isak W Tengesdal

J Biol Chem· September 2018

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NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis.
Carlo Marchetti, Benjamin Swartzwelter, Marije I Koenders, Tania Azam, Isak W Tengesdal

Arthritis Res Ther· August 2018

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MHC class II super-enhancer increases surface expression of HLA-DR and HLA-DQ and affects cytokine production in autoimmune vitiligo.
Giulio Cavalli, Masahiro Hayashi, Ying Jin, Daniel Yorgov, Stephanie A Santorico, Isak W Tengesdal

Proc Natl Acad Sci U S A· February 2016

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