Publications by authors named "Isao Tsuboi"

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Macrophage depletion using clodronate liposomes reveals latent dysfunction of the hematopoietic microenvironment associated with persistently imbalanced M1/M2 macrophage polarization in a mouse model of hemophagocytic lymphohistiocytosis.
Takashi Koike, Katsuhiro Miura, Yoshihiro Hatta, Hideki Nakamura, Yoko Hirabayashi, Isao Tsuboi

Ann Hematol· December 2023

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Imbalanced M1 and M2 Macrophage Polarization in Bone Marrow Provokes Impairment of the Hematopoietic Microenvironment in a Mouse Model of Hemophagocytic Lymphohistiocytosis.
Miyuki Yuda, Shin Aizawa, Isao Tsuboi, Yoko Hirabayashi, Tomonori Harada

Biol Pharm Bull· November 2022

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Age-related exacerbation of hematopoietic organ damage induced by systemic hyper-inflammation in senescence-accelerated mice.
Tomonori Harada, Isao Tsuboi, Hirotsugu Hino, Miyuki Yuda, Yoko Hirabayashi

Sci Rep· December 2021

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Kinetics of leukemic cells in 3D culture with stromal cells and with arginine deprivation stress.
Tomonori Harada, Isao Tsuboi, Mizuki Utsunomiya, Masahiro Yasuda, Shin Aizawa

J Biosci Bioeng· December 2020

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Dynamics of hematopoiesis is disrupted by impaired hematopoietic microenvironment in a mouse model of hemophagocytic lymphohistiocytosis.
Isao Tsuboi, Tomonori Harada, Yoko Hirabayashi, Shin Aizawa

Ann Hematol· July 2020

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Senescence-accelerated mice (SAMP1/TA-1) treated repeatedly with lipopolysaccharide develop a condition that resembles hemophagocytic lymphohistiocytosis.
Isao Tsuboi, Tomonori Harada, Yoko Hirabayashi, Shin Aizawa

Haematologica· October 2019

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Combined treatment with benzo[a]pyrene and 1α,25-dihydroxyvitamin D induces expression of plasminogen activator inhibitor 1 in monocyte/macrophage-derived cells.
Masaru Nakagawa, Shigeyuki Uno, Noriyoshi Iriyama, Manabu Matsunawa, Makoto Makishima, Isao Tsuboi

Toxicol Appl Pharmacol· April 2018

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Long-Term Hypoxic Tolerance in Murine Cornea.
Kazuhiro Kosaku, Tomonori Harada, Toyoharu Jike, Isao Tsuboi, Shin Aizawa

High Alt Med Biol· March 2018

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Differential Regulation of Lympho-Myelopoiesis by Stromal Cells in the Early and Late Phases in BALB/c Mice Repeatedly Exposed to Lipopolysaccharide.
Isao Tsuboi, Tomonori Harada, Yoko Hirabayashi, Jun Kanno, Shin Aizawa

Biol Pharm Bull· January 2017

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Kinetics of hematopoietic stem cells and supportive activities of stromal cells in a three-dimensional bone marrow culture system.
Tomonori Harada, Yukio Hirabayashi, Yoshihiro Hatta, Isao Tsuboi, Wilhelm Robert Glomm

Growth Factors· October 2016

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A case of a quadricuspid pulmonary valve in a Japanese female.
Tomonori Harada, Isao Tsuboi, Hiroyuki Hara, Michiko Naito, Kazuyuki Shimada

Anat Sci Int· September 2016

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Quantitative Analysis of Formaldehyde-induced Fluorescence in Paraffin-embedded Specimens of Malignant Melanomas and Other Melanocytic Lesions.
Hiroyuki Hara, Michiko Naito, Tomonori Harada, Isao Tsuboi, Tadashi Terui

Acta Derm Venereol· March 2016

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Cell cycle of primitive hematopoietic progenitors decelerated in senescent mice is reactively accelerated after 2-Gy whole-body irradiation.
Yoko Hirabayashi, Isao Tsuboi, Kazunao Kuramoto, Yoichiro Kusunoki, Tohru Inoue

Exp Biol Med (Maywood)· March 2016

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Lipopolysaccharide reciprocally alters the stromal cell-regulated positive and negative balance between myelopoiesis and B lymphopoiesis in C57BL/6 mice.
Masafumi Taki, Isao Tsuboi, Tomonori Harada, Michiko Naito, Hiroyuki Hara

Biol Pharm Bull· August 2015

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Decreased "ineffective erythropoiesis" preserves polycythemia in mice under long-term hypoxia.
Tomonori Harada, Isao Tsuboi, Yukio Hirabayashi, Kazuhiro Kosaku, Michiko Naito

Clin Exp Med· May 2015

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Experimentally induced, synergistic late effects of a single dose of radiation and aging: significance in LKS fraction as compared with mature blood cells.
Yoko Hirabayashi, Isao Tsuboi, Kei Nakachi, Yoichiro Kusunoki, Tohru Inoue

J Appl Toxicol· March 2015

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Age-related decline of mast cell regeneration in senescence-accelerated mice (SAMP1) after chemical myeloablation due to senescent stromal cell impairment.
Isao Tsuboi, Tomonori Harada, Yoko Hirabayashi, Jun Kanno, Tohru Inoue

Exp Biol Med (Maywood)· November 2012

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Mast cell development and biostresses: different stromal responses in bone marrow and spleen after treatment of myeloablater, 5-fluorouracil, and inflammatory stressor, lipopolysaccharide.
Takeo Hokari, Isao Tsuboi, Tomonori Harada, Hideki Oshima, Yoko Hirabayashi

Biol Pharm Bull· June 2012

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Neopterin, inflammation-associated product, prolongs erythropoiesis suppression in aged SAMP1 mice due to senescent stromal-cell impairment.
Kazuo Aisaki, Isao Tsuboi, Tomonori Harada, Hideki Oshima, Akiko Yamashita

Exp Biol Med (Maywood)· March 2012

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Asymmetric uptake of sepiapterin and 7,8-dihydrobiopterin as a gateway of the salvage pathway of tetrahydrobiopterin biosynthesis from the lumenal surface of rat endothelial cells.
Akiko Ohashi, Kaori Mamada, Isao Tsuboi, Shin Aizawa, Hiroyuki Hasegawa

Mol Genet Metab· November 2011

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Novel three-dimensional long-term bone marrow culture system using polymer particles with grafted epoxy-polymer-chains supports the proliferation and differentiation of hematopoietic stem cells.
Yukio Hirabayashi, Yoshihiro Hatta, Jin Takeuchi, Isao Tsuboi, Tomonori Harada

Exp Biol Med (Maywood)· November 2011

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Inflammatory biomarker, neopterin, predominantly enhances myelopoiesis, which suppresses erythropoiesis via activated stromal cells.
Isao Tsuboi, Tomonori Harada, Yoko Hirabayashi, Jun Kanno, Tohru Inoue

Immunobiology· May 2010

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Regeneration capability of Lin-/c-Kit+/Sca-1+ cells with or without radiation exposure for repopulation of peripheral blood in lethally irradiated mice monitored using Ly5.1 isotype on days 35, 90, and 270 after transplantation.
Kensuke Otsuka, Yoko Hirabayashi, Isao Tsuboi, Tohru Inoue

Exp Hematol· May 2010

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Comparison of murine gene expression profiles between spontaneous and radiation-induced myelogenous leukemias: stochastic and probabilistic expression variances in the former vs radiation-specific expression commonalities in the latter.
Yoko Hirabayashi, Isao Tsuboi, Kunio Kitada, Katsuhide Igarashi, Yukio Kodama

Exp Hematol· February 2009

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Predominant regeneration of B-cell lineage, instead of myeloid lineage, of the bone marrow after 1 Gy whole-body irradiation in mice: role of differential cytokine expression between B-cell stimulation by IL10, Flt3 ligand and IL7 and myeloid suppression by GM-CSF and SCF.
Isao Tsuboi, Yoko Hirabayashi, Tomonori Harada, Masaki Hiramoto, Jun Kanno

Radiat Res· July 2008

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