Publications by authors named "Ishwar Radhakrishnan"

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Per-ARNT-Sim (PAS) Domains in Basic Helix-Loop-Helix (bHLH)-PAS Transcription Factors and Coactivators: Structures and Mechanisms.
Nicolas Daffern, Ishwar Radhakrishnan

J Mol Biol· February 2024

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Histone acetylation and deacetylation - Mechanistic insights from structural biology.
Avinash B Patel, Yuan He, Ishwar Radhakrishnan

Gene· January 2024

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Prostaglandins as Candidate Ligands for a Per-ARNT-Sim (PAS) Domain of Steroid Receptor Coactivator 1 (SRC1).
Nicolas Daffern, Kade Kelley, José A Villegas, Ishwar Radhakrishnan

bioRxiv· July 2023

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Cryo-EM structure of the Saccharomyces cerevisiae Rpd3L histone deacetylase complex.
Avinash B Patel, Jinkang Qing, Kelly H Tam, Sara Zaman, Maria Luiso, Ishwar Radhakrishnan

Nat Commun· May 2023

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A Novel Mechanism of Coactivator Recruitment by the Nurr1 Nuclear Receptor.
Nicolas Daffern, Ishwar Radhakrishnan

J Mol Biol· August 2022

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A capped Tudor domain within a core subunit of the Sin3L/Rpd3L histone deacetylase complex binds to nucleic acid G-quadruplexes.
Ryan Dale Marcum, Joseph Hsieh, Maksim Giljen, Emily Justice, Nicolas Daffern, Ishwar Radhakrishnan

J Biol Chem· February 2022

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The neuronal transcription factor Myt1L interacts via a conserved motif with the PAH1 domain of Sin3 to recruit the Sin3L/Rpd3L histone deacetylase complex.
Ryan Dale Marcum, Ishwar Radhakrishnan

FEBS Lett· July 2020

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Inositol phosphates and core subunits of the Sin3L/Rpd3L histone deacetylase (HDAC) complex up-regulate deacetylase activity.
Ryan Dale Marcum, Ishwar Radhakrishnan

J Biol Chem· September 2019

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Solution Nuclear Magnetic Resonance Studies of the Ligand-Binding Domain of an Orphan Nuclear Receptor Reveal a Dynamic Helix in the Ligand-Binding Pocket.
Nicolas Daffern, Zhonglei Chen, Yongbo Zhang, Leslie Pick, Ishwar Radhakrishnan

Biochemistry· April 2018

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Solution NMR Studies of an Alternative Mode of Sin3 Engagement by the Sds3 Subunit in the Histone Deacetylase-Associated Sin3L/Rpd3L Corepressor Complex.
Michael David Clark, Yongbo Zhang, Ishwar Radhakrishnan

J Mol Biol· December 2015

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Molecular Basis for the Mechanism of Constitutive CBP/p300 Coactivator Recruitment by CRTC1-MAML2 and Its Implications in cAMP Signaling.
Michael David Clark, Ganesan Senthil Kumar, Ryan Marcum, Qianyi Luo, Yongbo Zhang, Ishwar Radhakrishnan

Biochemistry· September 2015

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Structural insights into the assembly of the histone deacetylase-associated Sin3L/Rpd3L corepressor complex.
Michael D Clark, Ryan Marcum, Richard Graveline, Clarence W Chan, Tao Xie, Ishwar Radhakrishnan

Proc Natl Acad Sci U S A· July 2015

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Structural Basis for Multi-specificity of MRG Domains.
Tao Xie, Adam M Zmyslowski, Yongbo Zhang, Ishwar Radhakrishnan

Structure· June 2015

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A role for WDR5 in integrating threonine 11 phosphorylation to lysine 4 methylation on histone H3 during androgen signaling and in prostate cancer.
Ji-Young Kim, Taraswi Banerjee, Aurimas Vinckevicius, Qianyi Luo, J Brandon Parker, Ishwar Radhakrishnan

Mol Cell· May 2014

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Mechanism of CREB recognition and coactivation by the CREB-regulated transcriptional coactivator CRTC2.
Qianyi Luo, Kristin Viste, Janny Concha Urday-Zaa, Ganesan Senthil Kumar, Wen-Wei Tsai, Ishwar Radhakrishnan

Proc Natl Acad Sci U S A· December 2012

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Sequence requirements for combinatorial recognition of histone H3 by the MRG15 and Pf1 subunits of the Rpd3S/Sin3S corepressor complex.
Ganesan Senthil Kumar, William Chang, Tao Xie, Anand Patel, Yongbo Zhang, Ishwar Radhakrishnan

J Mol Biol· September 2012

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Structural basis for molecular interactions involving MRG domains: implications in chromatin biology.
Tao Xie, Richard Graveline, Ganesan Senthil Kumar, Yongbo Zhang, Arvind Krishnan, Ishwar Radhakrishnan

Structure· January 2012

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Structure of the 30-kDa Sin3-associated protein (SAP30) in complex with the mammalian Sin3A corepressor and its role in nucleic acid binding.
Tao Xie, Yuan He, Hanna Korkeamaki, Yongbo Zhang, Rebecca Imhoff, Ishwar Radhakrishnan

J Biol Chem· August 2011

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Solution structure of the mSin3A PAH2-Pf1 SID1 complex: a Mad1/Mxd1-like interaction disrupted by MRG15 in the Rpd3S/Sin3S complex.
Ganesan Senthil Kumar, Tao Xie, Yongbo Zhang, Ishwar Radhakrishnan

J Mol Biol· May 2011

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Solution structure of a novel zinc finger motif in the SAP30 polypeptide of the Sin3 corepressor complex and its potential role in nucleic acid recognition.
Yuan He, Rebecca Imhoff, Anirban Sahu, Ishwar Radhakrishnan

Nucleic Acids Res· April 2009

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Program review. Challenges and opportunities for training the next generation of biophysicists: perspectives of the directors of the Molecular Biophysics Training Program at Northwestern University.
Francis Neuhaus, Jonathan Widom, Robert MacDonald, Theodore Jardetzky, Ishwar Radhakrishnan

Biopolymers· April 2008

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Conserved themes in target recognition by the PAH1 and PAH2 domains of the Sin3 transcriptional corepressor.
Sarata C Sahu, Kurt A Swanson, Richard S Kang, Kai Huang, Kurt Brubaker, Ishwar Radhakrishnan

J Mol Biol· February 2008

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Solution NMR studies of apo-mSin3A and -mSin3B reveal that the PAH1 and PAH2 domains are structurally independent.
Yuan He, Ishwar Radhakrishnan

Protein Sci· January 2008

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Structural basis for ubiquitin recognition by SH3 domains.
Yuan He, Linda Hicke, Ishwar Radhakrishnan

J Mol Biol· October 2007

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The structures that underlie normal reproductive function.
Thomas F Lerch, Min Xu, Theodore S Jardetzky, Kelly E Mayo, Ishwar Radhakrishnan

Mol Cell Endocrinol· March 2007

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