Publications by authors named "Isla Mackenzie"

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Bringing Trial Activities to Participants-The Trials@Home RADIAL Proof-of-Concept Trial Investigating Decentralization of Trials.
Mira G P Zuidgeest, Megan Heath, Bart Lagerwaard, Danny R van Weelij, Linda Rutgrink, Isla S Mackenzie

Clin Pharmacol Ther· November 2025

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Why and how do we perform physical examination(s) in clinical trials? A use case of drug intervention trials in type 2 diabetes mellitus.
Julia Kopanz, Amy Rogers, Lina Pérez-Breva, Emily Hall, Prashasthi Devaiah, Isla S Mackenzie

Br J Clin Pharmacol· September 2025

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Ischaemic cardiovascular risk with allopurinol and protective effect of colchicine in gout: a Dutch nationwide pharmaco-epidemiological study.
Iris Rose Peeters, Maike H M Wientjes, Isla S Mackenzie, Merel A A Opdam, Marcel Flendrie

Eur J Prev Cardiol· August 2025

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Clinical trials reimagined: Integrating community engagement and artificial intelligence.
Isla S Mackenzie, LaPrincess C Brewer, Alex Zhavoronkov

Med· June 2025

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Comparative effectiveness and prescribing trends of modified release versus immediate release indapamide in patients with hypertension: cohort study.
Vincent Ka Chun Yan, Chengsheng Ju, Thomas MacLennan MacDonald, Isla S Mackenzie, Robert Flynn

BMJ Med· February 2025

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Use of heart failure medical therapy before and after a cancer diagnosis: A longitudinal study.
Chengsheng Ju, Wallis C Y Lau, Charlotte Manisty, Pinkie Chambers, Ruth Brauer, Isla S Mackenzie

ESC Heart Fail· December 2024

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Vascular and inflammatory biomarkers of cardiovascular events in non-steroidal anti-inflammatory drug users.
Ricky Vaja, Plinio Ferreira, Laura Portas, Blerina Ahmetaj-Shala, Neringa Cypaite, Isla S Mackenzie

Eur Heart J Open· November 2024

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Genotype-Blinded Trial of Ambulatory Blood Pressure Response to Torasemide.
Linsay McCallum, Stefanie Lip, Alex McConnachie, Katriona Brooksbank, Iain M MacIntyre, Isla S Mackenzie

Hypertension· October 2024

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The Digital Platform and Its Emerging Role in Decentralized Clinical Trials.
Rachel R Copland, Sten Hanke, Amy Rogers, Lampros Mpaltadoros, Ioulietta Lazarou, Isla S Mackenzie

J Med Internet Res· September 2024

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Impact of Post Manufacturing Handling of Protein-Based Biologic Drugs on Product Quality and User Centricity.
Elia Cappelletto, Stanley C Kwok, Léa Sorret, Nathalie Fuentes, Annette M Medina, Isla S Mackenzie

J Pharm Sci· August 2024

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Getting our ducks in a row: The need for data utility comparisons of healthcare systems data for clinical trials.
Matthew R Sydes, Macey L Murray, Saiam Ahmed, Sophia Apostolidou, Judith M Bliss, Isla S Mackenzie

Contemp Clin Trials· June 2024

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Effect of timed dosing of usual antihypertensives according to patient chronotype on cardiovascular outcomes: the Chronotype sub-study cohort of the Treatment in Morning versus Evening (TIME) study.
Filippo Pigazzani, Kenneth A Dyar, Steve V Morant, Céline Vetter, Amy Rogers, Isla S Mackenzie

EClinicalMedicine· June 2024

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Effect of statin treatment on the risk of cancer in patients with heart failure: A target trial emulation study.
Chengsheng Ju, Wallis C Y Lau, Pinkie Chambers, Kenneth K C Man, Martin D Forster, Isla S Mackenzie

Pharmacoepidemiol Drug Saf· March 2024

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Allopurinol and cardiovascular outcomes in patients with ischaemic heart disease: the ALL-HEART RCT and economic evaluation.
Isla S Mackenzie, Christopher J Hawkey, Ian Ford, Nicola Greenlaw, Filippo Pigazzani

Health Technol Assess· March 2024

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Impact of beta-blockers on mortality and cardiovascular disease outcomes in patients with obstructive sleep apnoea: a population-based cohort study in target trial emulation framework.
Anthony Chen, Chengsheng Ju, Isla S Mackenzie, Thomas M MacDonald, Allan D Struthers

Lancet Reg Health Eur· October 2023

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The PREPARE study: benefits of pharmacogenetic testing are unclear.
Amy Rogers, Isla S Mackenzie, Thomas M MacDonald, Alexander S F Doney

Lancet· June 2023

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A cross-sectional survey on the early impact of COVID-19 on the uptake of decentralised trial methods in the conduct of clinical trials.
Arnela Suman, Jasmijn van Es, Helga Gardarsdottir, Diederick E Grobbee, Kimberly Hawkins, Isla S Mackenzie

Trials· October 2022

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Allopurinol versus usual care in UK patients with ischaemic heart disease (ALL-HEART): a multicentre, prospective, randomised, open-label, blinded-endpoint trial.
Isla S Mackenzie, Christopher J Hawkey, Ian Ford, Nicola Greenlaw, Filippo Pigazzani

Lancet· October 2022

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Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial.
Isla S Mackenzie, Amy Rogers, Neil R Poulter, Bryan Williams, Morris J Brown

Lancet· October 2022

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Serum uric acid lowering with empagliflozin in heart failure with reduced ejection fraction: a sweet added benefit?
Isla S Mackenzie, Thomas M MacDonald

Eur Heart J· September 2022

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The Prognostic Value of Derivatives-Reactive Oxygen Metabolites (d-ROMs) for Cardiovascular Disease Events and Mortality: A Review.
Filippo Pigazzani, Davide Gorni, Kenneth A Dyar, Matteo Pedrelli, Gwen Kennedy, Isla Mackenzie

Antioxidants (Basel)· August 2022

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A secondary qualitative analysis of stakeholder views about participant recruitment, retention, and adherence in decentralised clinical trials (DCTs).
Joanne Coyle, Amy Rogers, Rachel Copland, Giorgia De Paoli, Thomas M MacDonald, Isla S Mackenzie

Trials· July 2022

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A systematic review of methods used to conduct decentralised clinical trials.
Amy Rogers, Giorgia De Paoli, Selvarani Subbarayan, Rachel Copland, Kate Harwood, Isla S Mackenzie

Br J Clin Pharmacol· June 2022

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Adverse events and overall health and well-being after COVID-19 vaccination: interim results from the VAC4COVID cohort safety study.
Amy Rogers, Evelien Rooke, Steve Morant, Greg Guthrie, Alex Doney, Isla Mackenzie

BMJ Open· June 2022

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Evaluating Diuretics in Normal Care (EVIDENCE): a feasibility report of a pilot cluster randomised trial of prescribing policy in primary care to compare the effectiveness of thiazide-type diuretics in hypertension.
Angela Flynn, Amy Rogers, Lewis McConnachie, Rebecca Barr, Robert W V Flynn, Isla S Mackenzie

Pilot Feasibility Stud· March 2022

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