Publications by authors named "Ismael Companon"

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Microbial binding module employs sophisticated clustered saccharide patches to selectively adhere to mucins.
Thapakorn Jaroentomeechai, Billy Veloz, Cátia O Soares, Felix Goerdeler, Ana Sofia Grosso

Nat Commun· October 2025

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Balancing Antigen Loading on Gold Nanoparticles: Implications for Future Cancer Vaccine Strategies.
Mattia Ghirardello, Ana Guerreiro, Carmen Bretón, Ismael Compañón, Julio Zabalza

Chemistry· July 2025

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Structure-guided phage display discovery of antibodies for (S)Tn-glycans in protein context.
Ramon Hurtado-Guerrero, Spyridon Gatos, Irene Ginés-Alcober, Javier Macías-León, Andrés Manuel González-Ramírez

Nat Chem Biol· July 2025

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Non-Natural MUC1 Glycopeptide Homogeneous Cancer Vaccine with Enhanced Immunogenicity and Therapeutic Activity.
Ana Guerreiro, Ismael Compañón, Foivos S Lazaris, Carlos Labão-Almeida, Paula Oroz

Angew Chem Int Ed Engl· December 2024

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Rational Design of Dual-Domain Binding Inhibitors for -Acetylgalactosamine Transferase 2 with Improved Selectivity over the T1 and T3 Isoforms.
Ismael Compañón, Collin J Ballard, Erandi Lira-Navarrete, Tanausú Santos, Serena Monaco

JACS Au· September 2024

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Author Correction: Molecular basis for bacterial N-glycosylation by a soluble HMW1C-like N-glycosyltransferase.
Beatriz Piniello, Javier Macías-León, Shun Miyazaki, Ana García-García, Ismael Compañón

Nat Commun· February 2024

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Structure-Guided Approach for the Development of MUC1-Glycopeptide-Based Cancer Vaccines with Predictable Responses.
Iris A Bermejo, Ana Guerreiro, Ander Eguskiza, Nuria Martínez-Sáez, Foivos S Lazaris

JACS Au· January 2024

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Molecular basis for bacterial N-glycosylation by a soluble HMW1C-like N-glycosyltransferase.
Beatriz Piniello, Javier Macías-León, Shun Miyazaki, Ana García-García, Ismael Compañón

Nat Commun· September 2023

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Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut.
Víctor Taleb, Qinghua Liao, Yoshiki Narimatsu, Ana García-García, Ismael Compañón

Nat Commun· July 2022

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Structural basis for the synthesis of the core 1 structure by C1GalT1.
Andrés Manuel González-Ramírez, Ana Sofia Grosso, Zhang Yang, Ismael Compañón, Helena Coelho

Nat Commun· May 2022

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Single Mutation on Trastuzumab Modulates the Stability of Antibody-Drug Conjugates Built Using Acetal-Based Linkers and Thiol-Maleimide Chemistry.
Xhenti Ferhati, Ester Jiménez-Moreno, Emily A Hoyt, Giulia Salluce, Mar Cabeza-Cabrerizo

J Am Chem Soc· March 2022

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Atomic and Specificity Details of Mucin 1 -Glycosylation Process by Multiple Polypeptide GalNAc-Transferase Isoforms Unveiled by NMR and Molecular Modeling.
Helena Coelho, Matilde de Las Rivas, Ana S Grosso, Ana Diniz, Cátia O Soares

JACS Au· March 2022

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Efficient Amino-Sulfhydryl Stapling on Peptides and Proteins Using Bifunctional NHS-Activated Acrylamides.
Maria J S A Silva, Hélio Faustino, Jaime A S Coelho, Maria V Pinto, Adelaide Fernandes

Angew Chem Int Ed Engl· May 2021

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Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody.
Javier Macías-León, Iris A Bermejo, Alicia Asín, Ana García-García, Ismael Compañón

Chem Commun (Camb)· December 2020

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Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3.
Matilde de Las Rivas, Earnest James Paul Daniel, Yoshiki Narimatsu, Ismael Compañón, Kentaro Kato

Nat Chem Biol· March 2020

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Conformational Behavior of d-Lyxose in Gas and Solution Phases by Rotational and NMR Spectroscopies.
Camilla Calabrese, Patricia Écija, Ismael Compañón, Montserrat Vallejo-López, Álvaro Cimas

J Phys Chem Lett· June 2019

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Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine-Selective Protein Modification and Charge Modulation.
Maria J Matos, Claudio D Navo, Tuuli Hakala, Xhenti Ferhati, Ana Guerreiro

Angew Chem Int Ed Engl· May 2019

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Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage.
Ismael Compañón, Ana Guerreiro, Vincenzo Mangini, Jorge Castro-López, Margarita Escudero-Casao

J Am Chem Soc· March 2019

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Efficient and irreversible antibody-cysteine bioconjugation using carbonylacrylic reagents.
Barbara Bernardim, Maria J Matos, Xhenti Ferhati, Ismael Compañón, Ana Guerreiro

Nat Protoc· January 2019

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Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4.
Matilde de Las Rivas, Earnest James Paul Daniel, Helena Coelho, Erandi Lira-Navarrete, Lluis Raich

ACS Cent Sci· September 2018

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Water Sculpts the Distinctive Shapes and Dynamics of the Tumor-Associated Carbohydrate Tn Antigens: Implications for Their Molecular Recognition.
Iris A Bermejo, Imanol Usabiaga, Ismael Compañón, Jorge Castro-López, Aran Insausti

J Am Chem Soc· August 2018

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Structural Analysis of a GalNAc-T2 Mutant Reveals an Induced-Fit Catalytic Mechanism for GalNAc-Ts.
Matilde de Las Rivas, Helena Coelho, Ana Diniz, Erandi Lira-Navarrete, Ismael Compañón

Chemistry· June 2018

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Cell-Penetrating Peptides Containing Fluorescent d-Cysteines.
Claudio D Navo, Alicia Asín, Eva Gómez-Orte, Marta I Gutiérrez-Jiménez, Ismael Compañón

Chemistry· June 2018

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The Use of Fluoroproline in MUC1 Antigen Enables Efficient Detection of Antibodies in Patients with Prostate Cancer.
Víctor J Somovilla, Iris A Bermejo, Inês S Albuquerque, Nuria Martínez-Sáez, Jorge Castro-López

J Am Chem Soc· December 2017

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The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences.
Matilde de Las Rivas, Erandi Lira-Navarrete, Earnest James Paul Daniel, Ismael Compañón, Helena Coelho

Nat Commun· December 2017

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