Publications by authors named "Issam Awad"

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Guidelines for the Diagnosis and Clinical Management of Cavernous Malformations of the Brain and Spinal Cord: Consensus Recommendations Based on a Systematic Literature Review by the Alliance to Cure Cavernous Malformation Clinical Advisory Board Experts Panel.
Amy L Akers, John Albanese, Roberto J Alcazar-Felix, Rustam Al-Shahi Salman, Issam A Awad

Neurosurgery· January 2026

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Identifying features of prior hemorrhage in cerebral cavernous malformations on quantitative susceptibility maps: a machine learning pilot study.
Serena Kinkade, Hui Li, Stephanie Hage, Janne Koskimäki, Agnieszka Stadnik, Issam A Awad

J Neurosurg· December 2025

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Recurrent somatic copy number alterations in resected cerebral cavernous malformations.
Andrew K Ressler, Evon Debose-Scarlett, Amanda Fuenzalida, Rhonda Lightle, Shantel Weinsheimer, Issam Awad

Hum Genomics· December 2025

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The Infundibulum-Aneurysm Conundrum: A Longitudinal Single-Center Analysis.
Sammy Allaw, Abhinav Srinath, Dominic M Montas, Fidel Haro, Roberto Alcazar-Felix, Issam A Awad

AJNR Am J Neuroradiol· December 2025

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Integration of artificial intelligence and high-content screening enabled identification of drugs for long-term treatment of cerebral cavernous malformation disease.
Eduardo Frias-Anaya, Helios Gallego-Gutierrez, Cassandra Bui, Janeth Ochoa Birrueta, Jeffrey Steinberg, Issam A Awad

bioRxiv· December 2025

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Hematoma Evacuation and Risk of Subsequent Ischemic Stroke and Coronary Ischemic Events: MISTIE III and ATACH-2 Analysis.
Wendy C Ziai, William Harris, Adnan I Qureshi, Issam Awad, Daniel F Hanley

medRxiv· November 2025

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Relevance of Lesion Volume as an Outcome in Cerebral Cavernous Malformation Drug Trial: Exploratory Analyses in Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept.
Roberto J Alcazar-Felix, Richard E Thompson, Agnieszka Stadnik, Serena Kinkade, Georgio Sader, Issam A Awad

Neurosurgery· October 2025

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Safety, Tolerability, and Pharmacokinetics of NRL-1049, a Rho-Associated Kinase Inhibitor, in Healthy Volunteers: A Phase 1, First-in-Human, Single-Ascending Dose, Randomized, Placebo-Controlled Trial.
Stuart Madden, Issam Awad, Miguel A Lopez-Toledano, Leslie Morrison, Juan Gutierrez

CNS Drugs· September 2025

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Common and distinct circulating microRNAs in four neurovascular disorders.
Janne Koskimäki, Aditya Jhaveri, Abhinav Srinath, Akash Bindal, Diana Vera Cruz, Issam A Awad

Biochem Biophys Rep· September 2025

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Association of Quality of Life Domains and Clinical Symptoms in Patients With Familial Cerebral Cavernous Malformation.
Cynthia Tsang, Jeffrey Nelson, Rachel Vassar, Nerissa U Ko, Charles McCulloch, Issam A Awad

J Am Heart Assoc· September 2025

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Impact of Minimally Invasive Surgery on Midline Shift and Outcomes in Large Supratentorial Spontaneous Intracerebral Hemorrhage: Post Hoc Analysis of MISTIE III.
Wendy C Ziai, Anusha Yarava, Joshua B Gruber, Yunke Li, Nathan Walborn, Issam Awad

Neurocrit Care· September 2025

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A mouse model of stereotactic radiosurgery-induced neuroinflammation and blood-brain barrier compromise.
Roberto J Alcazar-Felix, Lin Cheng, Abhinav Srinath, Akash Bindal, David Tieri, Issam A Awad

Acta Neuropathol Commun· September 2025

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Except for Robust Outliers, Rapamycin Increases Lesion Burden in a Murine Model of Cerebral Cavernous Malformations.
Roberto J Alcazar-Felix, Robert Shenkar, Christian R Benavides, Akash Bindal, Abhinav Srinath, Issam A Awad

Transl Stroke Res· June 2025

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Circulating molecules reflect imaging biomarkers of hemorrhage in cerebral cavernous malformations.
Stephanie F Hage, Dehua E Bi, Serena Kinkade, Diana Vera Cruz, Abhinav Srinath, Issam A Awad

J Cereb Blood Flow Metab· June 2025

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Code ICH: reorganising stroke care for intracerebral haemorrhage.
Wendy Ziai, Issam Awad, Daniel Hanley

J Neurol Neurosurg Psychiatry· April 2025

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Safety and efficacy of atorvastatin for rebleeding in cerebral cavernous malformations (AT CASH EPOC): a phase 1/2a, randomised placebo-controlled trial.
Issam A Awad, Roberto J Alcazar-Felix, Agnieszka Stadnik, Serena Kinkade, Aditya Jhaveri

Lancet Neurol· April 2025

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Intracerebral haemorrhage laterality and associations with mood and pain: a MISTIE III substudy.
Dawson C Cooper, Efrat Abramson, Wendy C Ziai, Matthew L Flaherty, Vishank A Shah, Issam Awad

Stroke Vasc Neurol· April 2025

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A Systematic Review of MicroRNAs in Hemorrhagic Neurovascular Disease: Cerebral Cavernous Malformations as a Paradigm.
Roberto J Alcazar-Felix, Aditya Jhaveri, Javed Iqbal, Abhinav Srinath, Carolyn Bennett, Issam A Awad

Int J Mol Sci· April 2025

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Intracerebral Hemorrhage: Keep It Simple.
Daniel F Hanley, Wendy C Ziai, Farhaan S Vahidy, Sean Polster, Nichol A McBee, Issam A Awad

Stroke· December 2024

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Fourth-generation Pipeline Vantage flow diversion: First reported US experience of safety and feasibility.
Ahmad Sweid, Ahmad Chahine, Stephanie Hage, Rami Z Morsi, Sonam Thind, Issam Awad

Interv Neuroradiol· December 2024

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Epigenetic regulation by polycomb repressive complex 1 promotes cerebral cavernous malformations.
Van-Cuong Pham, Claudia Jasmin Rödel, Mariaelena Valentino, Matteo Malinverno, Alessio Paolini, Issam A Awad

EMBO Mol Med· November 2024

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Does stereotactic thrombolysis with alteplase for intracerebral haemorrhage alter intraventricular haematoma volume? A secondary analysis of the MISTIE-III trial.
Philip Sun, Shervin Badihian, Radhika Avadhani, Nathan Walborn, Anusha Yarava, Issam Awad

J Neurol Neurosurg Psychiatry· September 2024

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Pathologic features of brain hemorrhage after radiation treatment: case series with somatic mutation analysis.
Roberto J Alcazar-Felix, Abhinav Srinath, Stephanie Hage, Akash Bindal, Andrew Ressler, Issam A Awad

J Stroke Cerebrovasc Dis· July 2024

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Mild Hypoxia Accelerates Cerebral Cavernous Malformation Disease Through CX3CR1-CX3CL1 Signaling.
Eduardo Frias-Anaya, Helios Gallego-Gutierrez, Brendan Gongol, Shantel Weinsheimer, Catherine Chinhchu Lai, Issam A Awad

Arterioscler Thromb Vasc Biol· June 2024

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Antithrombotic Therapy in Cerebral Cavernous Malformations: A Systematic Review, Meta-Analysis, and Network Meta-Analysis.
Basel Musmar, Hamza Salim, Jihad Abdelgadir, Samantha Spellicy, Nimer Adeeb, Issam Awad

J Am Heart Assoc· March 2024

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