Publications by authors named "Issam Hmila"

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Enhanced Cellular Uptake of Compact Cas Proteins: A Comparative Study of Cas12f and Cas9 in Human Cells.
Karim E Shalaby, Issam Hmila, S M Nasir Uddin, Nasser H Zawia, Omar M A El-Agnaf

Eng Life Sci· September 2025

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Perinatal exposure to PFOS and sustained high-fat diet promote neurodevelopmental disorders via genomic reprogramming of pathways associated with neuromotor development.
Issam Hmila, Jaunetta Hill, Karim E Shalaby, Khalid Ouararhni, Houari Abedsselem

Ecotoxicol Environ Saf· March 2024

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Structural insights into the unique recognition module between α-synuclein peptide and nanobody.
Zeyaul Islam, Nishant N Vaikath, Issam Hmila, Omar M A El-Agnaf, Prasanna R Kolatkar

Protein Sci· February 2024

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Aptamer-Assisted Proximity Ligation Assay for Sensitive Detection of Infectious Bronchitis Coronavirus.
Issam Hmila, Boutheina Marnissi, Masood Kamali-Moghaddam, Abdeljelil Ghram

Microbiol Spectr· February 2023

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Production of α-Synuclein Fibrillar-Specific scFv from Inclusion Bodies.
Vijay Gupta, Issam Hmila, Nishant N Vaikath, Indulekha P Sudhakaran, Omar M A El-Agnaf

Methods Mol Biol· January 2023

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Inhibition of α-Synuclein Seeding-Dependent Aggregation by ssDNA Aptamers Specific to C-Terminally Truncated α-Synuclein Fibrils.
Issam Hmila, Indulekha P Sudhakaran, Simona S Ghanem, Nishant N Vaikath, Ilaria Poggiolini

ACS Chem Neurosci· December 2022

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Novel engineered nanobodies specific for N-terminal region of alpha-synuclein recognize Lewy-body pathology and inhibit in-vitro seeded aggregation and toxicity.
Issam Hmila, Nishant N Vaikath, Nour K Majbour, Daniel Erskine, Indulekha P Sudhakaran

FEBS J· August 2022

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Accurate detection of Newcastle disease virus using proximity-dependent DNA aptamer ligation assays.
Boutheina Marnissi, Khouloud Khalfaoui, Tonge Ebai, Felipe Marques Souza de Oliveira, Abdeljelil Ghram, Issam Hmila

FEBS Open Bio· April 2021

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Expression, purification and characterization of α-synuclein fibrillar specific scFv from inclusion bodies.
Vijay Gupta, Indulekha P Sudhakaran, Zeyaul Islam, Nishant N Vaikath, Issam Hmila

PLoS One· January 2021

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Generation of ssDNA aptamers as diagnostic tool for Newcastle avian virus.
Boutheina Marnissi, Masood Kamali-Moghaddam, Abdeljelil Ghram, Issam Hmila

PLoS One· October 2020

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Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity.
Vijay Gupta, Safa Salim, Issam Hmila, Nishant N Vaikath, Indulekha P Sudhakaran

Sci Rep· May 2020

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Antibodies against alpha-synuclein: tools and therapies.
Nishant N Vaikath, Issam Hmila, Vijay Gupta, Daniel Erskine, Martin Ingelsson

J Neurochem· September 2019

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A multiplex real-time RT-PCR for simultaneous detection of four most common avian respiratory viruses.
Nacira Laamiri, Rim Aouini, Boutheina Marnissi, Abdeljelil Ghram, Issam Hmila

Virology· February 2018

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Hyalomma dromedarii (Acari: Ixodidae) Salivary Gland Extract Inhibits Angiogenesis and Exhibits In Vitro Antitumor Effects.
Chaima Bensaoud, Zaineb Abdelkafi-Koubaa, Hazem Ben Mabrouk, Maram Morjen, Issam Hmila

J Med Entomol· November 2017

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A novel method for detection of H9N2 influenza viruses by an aptamer-real time-PCR.
Issam Hmila, Manoosak Wongphatcharachai, Nacira Laamiri, Rim Aouini, Boutheina Marnissi

J Virol Methods· May 2017

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Accurate Detection of Avian Respiratory Viruses by Use of Multiplex PCR-Based Luminex Suspension Microarray Assay.
Nacira Laamiri, Pia Fällgren, Siamak Zohari, Jaouher Ben Ali, Abdeljelil Ghram, Issam Hmila

J Clin Microbiol· November 2016

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Efficient expression of the anti-AahI' scorpion toxin nanobody under a new functional form in a Pichia pastoris system.
Aymen Ezzine, Sonia M'hirsi El Adab, Balkiss Bouhaouala-Zahar, Issam Hmila, Laura Baciou

Biotechnol Appl Biochem· October 2012

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Pre-clinical studies of toxin-specific nanobodies: evidence of in vivo efficacy to prevent fatal disturbances provoked by scorpion envenoming.
Issam Hmila, Bernard Cosyns, Hayfa Tounsi, Bram Roosens, Vicky Caveliers

Toxicol Appl Pharmacol· October 2012

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Immunological aspects of scorpion toxins: current status and perspectives.
Balkiss Bouhaouala-Zahar, Rahma Ben Abderrazek, Issam Hmila, Naima Abidi, Serge Muyldermans

Inflamm Allergy Drug Targets· October 2011

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Development of Cys38 knock-out and humanized version of NbAahII10 nanobody with improved neutralization of AahII scorpion toxin.
Rahma Ben Abderrazek, Cécile Vincke, Issam Hmila, Dirk Saerens, Naima Abidi

Protein Eng Des Sel· September 2011

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A bispecific nanobody to provide full protection against lethal scorpion envenoming.
Issam Hmila, Dirk Saerens, Rahma Ben Abderrazek, Cécile Vincke, Naima Abidi

FASEB J· September 2010

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Identification of potent nanobodies to neutralize the most poisonous polypeptide from scorpion venom.
Rahma Ben Abderrazek, Issam Hmila, Cécile Vincke, Zakaria Benlasfar, Mireille Pellis

Biochem J· November 2009

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VHH, bivalent domains and chimeric Heavy chain-only antibodies with high neutralizing efficacy for scorpion toxin AahI'.
Issam Hmila, Ben Abderrazek-Ben Abdallah R, Dirk Saerens, Zakaria Benlasfar, Katja Conrath

Mol Immunol· August 2008

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