Publications by authors named "Istvan Greiner"

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Discovery of an In Vitro and In Vivo Potent Nicotinic α7 Positive Allosteric Modulator Clinical Candidate Molecule (RGH-857).
István Ledneczki, Pál Tapolcsányi, Eszter Gábor, István Vágó, Áron Szigetvári, István Greiner

J Med Chem· December 2025

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Continuous-flow synthesis of 1,4,6,7-tetrahydro-5-[1,2,3]triazolo[4,5-]pyridines towards key intermediates of clinical candidates JNJ-54175446 and zanvipixant (JNJ-55308942) with antidepressant activity.
Zsolt Fülöp, Péter Bana, István Greiner, János Éles

RSC Adv· July 2025

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Harnessing dual-mode RIPK1 ligands for cross-species anti-necroptosis inhibitor compounds.
József Levente Petró, Péter Bana, Nikolett Linke, Judit Eszter Szabó, Krisztina Katalin Szalai, István Greiner

Bioorg Med Chem Lett· November 2024

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Design, synthesis and biological evaluation of novel cyclic malonamide derivatives as selective RIPK1 inhibitors.
József Levente Petró, Gyula Bényei, Péter Bana, Nikolett Linke, Ferenc Horti, István Greiner

Bioorg Med Chem Lett· March 2024

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Discovery of Novel Steroid-Based Histamine H Receptor Antagonists/Inverse Agonists.
István Ledneczki, Pál Tapolcsányi, Eszter Gábor, János Éles, Júlia Barabás, István Greiner

J Med Chem· March 2024

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Novel-Type GABA PAMs: Structure-Activity Relationship in Light of the Protein Structure.
Balázs Krámos, Zsuzsa Hadady, Attila Makó, Gábor Szántó, Nóra Felföldi, István Greiner

ACS Med Chem Lett· March 2024

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Discovery and Characterization of RGH-122, a Potent, Selective, and Orally Bioavailable V1a Receptor Antagonist.
Ferenc Baska, Éva Bozó, Zsolt Szeleczky, Gábor Szántó, Krisztina Vukics, István Greiner

J Med Chem· January 2024

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Optimization of Novel α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators and the Discovery of a Preclinical Development Candidate Molecule (RGH-560).
István Ledneczki, Zsolt Némethy, Katalin Dudásné Molnár, Pál Tapolcsányi, Viktor Ilkei, István Greiner

J Med Chem· December 2023

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6-Aryl-quinazolines as novel GABA receptor positive allosteric modulators.
József Huszár, József Levente Petró, Zsuzsa Hadady, Amrita Ágnes Bobok, Katalin Sághy, István Greiner

Bioorg Med Chem Lett· July 2022

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Multiparameter Optimization of Naphthyridine Derivatives as Selective α5-GABA Receptor Negative Allosteric Modulators.
György Szabó, Olivér Éliás, Péter Erdélyi, Attila Potor, György I Túrós, István Greiner

J Med Chem· June 2022

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hERG Optimization of Benzofuro-Pyridine and Pyrazino-Indole Derivatives as MCHR1 Antagonists.
József Huszár, Éva Bozó, Gyula Beke, Krisztina Katalin Szalai, Péter Kardos, István Greiner

ChemMedChem· April 2022

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A Mechanistic Study on the Formation of Dronic Acids.
Péter Ábrányi-Balogh, István Greiner, György Keglevich

Molecules· December 2021

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HTS-based discovery and optimization of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor.
István Ledneczki, Anita Horváth, Pál Tapolcsányi, János Éles, Katalin Dudás Molnár, István Greiner

Eur J Med Chem· October 2021

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Synthesis and Characterization of New V Antagonist Compounds: The Separation of Four Atropisomeric Stereoisomers.
Zsolt Szeleczky, Zoltán Szakács, Éva Bozó, Ferenc Baska, Krisztina Vukics, István Greiner

J Med Chem· July 2021

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Fragment-Based Optimization of Dihydropyrazino-Benzimidazolones as Metabotropic Glutamate Receptor-2 Positive Allosteric Modulators against Migraine.
György Szabó, Péter Erdélyi, Sándor Kolok, Mónika Vastag, Attila S Halász, István Greiner

J Med Chem· June 2021

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C-N Bond Formation by Consecutive Continuous-Flow Reductions towards A Medicinally Relevant Piperazine Derivative.
Zsolt Fülöp, Péter Bana, István Greiner, János Éles

Molecules· April 2021

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Discovery of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor: Scaffold hopping approach.
István Ledneczki, Pál Tapolcsányi, Eszter Gábor, András Visegrády, Márton Vass, István Greiner

Eur J Med Chem· March 2021

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Controlling receptor function from the extracellular vestibule of G-protein coupled receptors.
Attila Egyed, Katalin Domány-Kovács, Bence Koványi, Ferenc Horti, Dalma Kurkó, István Greiner

Chem Commun (Camb)· November 2020

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Discovery of dihydropyrazino-benzimidazole derivatives as metabotropic glutamate receptor-2 (mGluR2) positive allosteric modulators (PAMs).
György Szabó, Sándor Kolok, Zoltán Orgován, Mónika Vastag, Zoltán Béni, István Greiner

Eur J Med Chem· January 2020

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Discovery of novel steroidal histamine H receptor antagonists/inverse agonists. Part 2. Versatile steroidal carboxamide derivatives.
István Ledneczki, Zsolt Némethy, Pál Tapolcsányi, János Éles, István Greiner

Bioorg Med Chem Lett· October 2019

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Fragment Based Optimization of Metabotropic Glutamate Receptor 2 (mGluR2) Positive Allosteric Modulators in the Absence of Structural Information.
György Szabó, György I Túrós, Sándor Kolok, Mónika Vastag, Zsuzsanna Sánta, István Greiner

J Med Chem· January 2019

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Biomimetic Synthesis of Drug Metabolites in Batch and Continuous-Flow Reactors.
Tamás Fődi, Gergő Ignácz, Balázs Decsi, Zoltán Béni, György I Túrós, István Greiner

Chemistry· July 2018

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Discovery of novel steroidal histamine H receptor antagonists/inverse agonists.
Istvan Ledneczki, Pál Tapolcsányi, Eszter Gábor, János Éles, István Greiner

Bioorg Med Chem Lett· October 2017

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Continuous Synthesis and Purification by Coupling a Multistep Flow Reaction with Centrifugal Partition Chromatography.
Róbert Örkényi, János Éles, Ferenc Faigl, Péter Vincze, Anita Prechl, István Greiner

Angew Chem Int Ed Engl· July 2017

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Discovery of 4-amino-3-arylsulfoquinolines, a novel non-acetylenic chemotype of metabotropic glutamate 5 (mGlu) receptor negative allosteric modulators.
János Galambos, Attila Bielik, Gábor Wágner, György Domány, János Kóti, István Greiner

Eur J Med Chem· June 2017

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