Publications by authors named "Ivo Melo"

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FL/FLT3 signaling enhances mechanical pain hypersensitivity through Interleukin-1 beta (IL-1β) in male mice.
Corinne Sonrier, Chamroen Sar, Ivo Melo, Lucie Dioufoulet, Gabriel V Lucena-Silva

Neurobiol Pain· December 2025

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Nicorandil antiallodynic activity in a model of neuropathic pain is associated with the activation of ATP-dependent potassium channels and opioidergic pathways, and reduced production of cytokines and neutrophils recruitment in paw, sciatic nerve, and dorsal root ganglia.
Alysson V Braga, Marcela Í Morais, Darly G S Delfino, Sarah O A M Costa, Bárbara C M Barbosa, Ivo S F Melo

Pharmacol Rep· October 2024

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Metformin inhibits paclitaxel-induced mechanical allodynia by activating opioidergic pathways and reducing cytokines production in the dorsal root ganglia and thalamus.
Marcela Í Morais, Alysson V Braga, Roger R L Silva, Bárbara C M Barbosa, Sarah O A M Costa, Ivo S F Melo

Cytokine· February 2024

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A clindamycin acetylated derivative with reduced antibacterial activity inhibits articular hyperalgesia and edema by attenuating neutrophil recruitment, NF-κB activation and tumor necrosis factor-α production.
Felipe F Rodrigues, Cleudiomar I Lino, Vívian L S Oliveira, Isabella Zaidan, Ivo S F Melo

Int Immunopharmacol· September 2023

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Synthesis of 2-(2-(4-thioxo-3H-1,2-dithiole-5-yl) phenoxy)ethyl)isoindole-1,3-thione, a novel hydrogen sulfide-releasing phthalimide hybrid, and evaluation of its activity in models of inflammatory pain.
Ivo S F Melo, Victor P Ziviani, Barbara C M Barbosa, Felipe F Rodrigues, Roger R L Silva

Eur J Pharmacol· January 2023

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Chenopodin as an anti-inflammatory compound.
Dávia Guimarães Pompeu, Helon Guimarães Cordeiro, Flávia Cristina Policarpo Tonelli, Adriana Martins Godin, Ivo Souza Ferraz de Melo

Nat Prod Res· September 2022

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RI75, a curcumin analogue, inhibits tumor necrosis factor-α and interleukin-6 production and exhibits antiallodynic and antiedematogenic activities in mice.
Sarah O A M Costa, Ianny B Rodrigues, Alysson V Braga, Bárbara C M Barbosa, Roger R L Silva, Ivo S F Melo

Inflammopharmacology· April 2022

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Metformin effect in models of inflammation is associated with activation of ATP-dependent potassium channels and inhibition of tumor necrosis factor-α production.
Paulo S A Augusto, Tamires C Matsui, Alysson V Braga, Felipe F Rodrigues, Marcela I Morais, Ivo S F Melo

Inflammopharmacology· February 2022

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Electrochemical evidence of nitrate release from the nitrooxy compound 4-((nitrooxy) methyl)-3-nitrobenzoic acid and its antinociceptive and anti-inflammatory activities in mice.
Alysson Vinícius Braga, Roger Ryuler Lisboa da Silva, Ianny Bandeira Rodrigues, Gabriel Vitor de Lima Marques, Andre Felippe de Almeida Xavier, Ivo Souza Ferraz Melo

Biomed Pharmacother· January 2021

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Clindamycin inhibits nociceptive response by reducing tumor necrosis factor-α and CXCL-1 production and activating opioidergic mechanisms.
Felipe F Rodrigues, Marcela I Morais, Ivo S F Melo, Paulo S A Augusto, Marcela M G B Dutra

Inflammopharmacology· April 2020

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Thiamine, riboflavin, and nicotinamide inhibit paclitaxel-induced allodynia by reducing TNF-α and CXCL-1 in dorsal root ganglia and thalamus and activating ATP-sensitive potassium channels.
Alysson V Braga, Sarah O A M Costa, Felipe F Rodrigues, Ivo S F Melo, Marcela I Morais

Inflammopharmacology· February 2020

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The phthalimide analogues N-3-hydroxypropylphthalimide and N-carboxymethyl-3-nitrophthalimide exhibit activity in experimental models of inflammatory and neuropathic pain.
Carla R A Batista, Adriana M Godin, Ivo S F Melo, Giovanna M E Coura, Tamires C Matsui

Pharmacol Rep· December 2019

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Metformin antinociceptive effect in models of nociceptive and neuropathic pain is partially mediated by activation of opioidergic mechanisms.
Paulo S A Augusto, Alysson V Braga, Felipe F Rodrigues, Marcela I Morais, Marcela M G B Dutra, Ivo S F Melo

Eur J Pharmacol· September 2019

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4-Methylbenzenecarbothioamide, a hydrogen sulfide donor, inhibits tumor necrosis factor-α and CXCL1 production and exhibits activity in models of pain and inflammation.
Ivo S F Melo, Felipe F Rodrigues, Sarah O A M Costa, Alysson Vinícius Braga, Marcela Ísis Morais

Eur J Pharmacol· August 2019

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Nicorandil inhibits mechanical allodynia induced by paclitaxel by activating opioidergic and serotonergic mechanisms.
Marcela I Morais, Felipe F Rodrigues, Sarah O A M Costa, Franciele A Goulart, Fábio C Costa, Ivo S F Melo

Eur J Pharmacol· April 2018

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Antiallodynic activity of leflunomide is partially inhibited by naltrexone and glibenclamide and associated with reduced production of TNF-α and CXCL-1.
Ana Mercy S Brito, Adriana M Godin, Paulo Sérgio A Augusto, Raquel R Menezes, Ivo S F Melo

Eur J Pharmacol· January 2018

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Thiamine and riboflavin inhibit production of cytokines and increase the anti-inflammatory activity of a corticosteroid in a chronic model of inflammation induced by complete Freund's adjuvant.
Raquel R Menezes, Adriana M Godin, Felipe Fernandes Rodrigues, Giovanna M E Coura, Ivo S F Melo

Pharmacol Rep· October 2017

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2-Phthalimidethanol and 2-phthalimidethyl nitrate inhibit mechanical allodynia, neutrophil recruitment and cytokine and chemokine production in a murine model of articular inflammation.
Adriana M Godin, Débora P Araújo, Raquel R Menezes, Ana M S de Brito, Ivo S F Melo

Pharmacol Rep· August 2017

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Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease.
Kris Simone T Dias, Cynthia T de Paula, Thiago Dos Santos, Isis N O Souza, Marina S Boni, Ivo Souza F de Melo

Eur J Med Chem· April 2017

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Opioid pathways activation mediates the activity of nicorandil in experimental models of nociceptive and inflammatory pain.
Marcela M G B Dutra, Elias B Nascimento Júnior, Adriana M Godin, Ana Mercy S Brito, Ivo S F Melo

Eur J Pharmacol· December 2015

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Nicorandil inhibits neutrophil recruitment in carrageenan-induced experimental pleurisy in mice.
Tamires C Matsui, Giovanna M E Coura, Ivo S F Melo, Carla R A Batista, Paulo Sérgio A Augusto

Eur J Pharmacol· December 2015

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Activities of 2-phthalimidethyl nitrate and 2-phthalimidethanol in the models of nociceptive response and edema induced by formaldehyde in mice and preliminary investigation of the underlying mechanisms.
Adriana M Godin, Débora P Araújo, Isabela C César, Raquel R Menezes, Ana Mercy S Brito, Ivo S F Melo

Eur J Pharmacol· June 2015

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Activities of 2-phthalimidethanol and 2-phthalimidethyl nitrate, phthalimide analogs devoid of the glutarimide moiety, in experimental models of inflammatory pain and edema.
Adriana M Godin, Débora P Araújo, Raquel R Menezes, Ana Mercy S Brito, Ivo S F Melo

Pharmacol Biochem Behav· July 2014

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Anti-inflammatory and antinociceptive activities of azadirachtin in mice.
Darly G Soares, Adriana M Godin, Raquel R Menezes, Rafaela D Nogueira, Ana Mercy S Brito, Ivo S F Melo

Planta Med· June 2014

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Role of PPAR-gamma in the modulation of CD36 and FcgammaRII induced by LDL with low and high degrees of oxidation during the differentiation of the monocytic THP-1 cell line.
Francisco J O Rios, Sonia Jancar, Ivo B Melo, Daniel F J Ketelhuth, Magnus Gidlund

Cell Physiol Biochem· February 2009

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