Publications by authors named "Jack D Chan"

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Tumor site-directed A1R expression enhances CAR T cell function and improves efficacy against solid tumors.
Kevin Sek, Amanda X Y Chen, Thomas Cole, Jesse D Armitage, Junming Tong, Cheok Weng Chan, Jack D Chan

Nat Commun· July 2025

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FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy.
Jack D Chan, Christina M Scheffler, Isabelle Munoz, Kevin Sek, Joel N Lee, Cheok Weng Chan

Nature· May 2024

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CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity.
Imran G House, Emily B Derrick, Kevin Sek, Amanda X Y Chen, Jasmine Li, Cheok Weng Chan, Jack D Chan

Cell Rep· February 2024

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CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity.
Imran G House, Emily B Derrick, Kevin Sek, Amanda X Y Chen, Jasmine Li, Cheok Weng Chan, Jack D Chan

Cell Rep· August 2023

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Cellular networks controlling T cell persistence in adoptive cell therapy.
Jack D Chan, Junyun Lai, Clare Y Slaney, Axel Kallies, Paul A Beavis

Nat Rev Immunol· December 2021

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A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer.
Aesha I Ali, Minyu Wang, Bianca von Scheidt, Pilar M Dominguez, Aaron J Harrison, Jack D Chan

Clin Cancer Res· November 2021

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MAIT cells regulate NK cell-mediated tumor immunity.
Emma V Petley, Hui-Fern Koay, Melissa A Henderson, Kevin Sek, Kirsten L Todd, Jack D Chan

Nat Commun· August 2021

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Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity.
Junyun Lai, Sherly Mardiana, Imran G House, Kevin Sek, Melissa A Henderson, Jack D Chan

Nat Immunol· August 2020

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Chimeric antigen receptor T cell therapies for thoracic cancers-challenges and opportunities.
Jack D Chan, Aaron J Harrison, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney

J Thorac Dis· August 2020

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Enhancing chimeric antigen receptor T-cell immunotherapy against cancer using a nanoemulsion-based vaccine targeting cross-presenting dendritic cells.
Jack D Chan, Bianca von Scheidt, Bijun Zeng, Amanda J Oliver, Ashleigh S Davey

Clin Transl Immunology· July 2020

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p38 Kinase: A Key Target for Driving Potent T Cells for Adoptive Immunotherapy.
Jack D Chan, Paul A Beavis, Phillip K Darcy

Cancer Cell· June 2020

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Enterotoxins can support CAR T cells against solid tumors.
Bianca von Scheidt, Minyu Wang, Amanda J Oliver, Jack D Chan, Metta K Jana

Proc Natl Acad Sci U S A· December 2019

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Tissue-specific tumor microenvironments influence responses to immunotherapies.
Amanda J Oliver, Ashleigh S Davey, Simon P Keam, Sherly Mardiana, Jack D Chan

Clin Transl Immunology· November 2019

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Genetic Redirection of T Cells for the Treatment of Pancreatic Cancer.
Aesha I Ali, Amanda J Oliver, Tinaz Samiei, Jack D Chan, Michael H Kershaw

Front Oncol· February 2019

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