Publications by authors named "Jack D Sadowsky"

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Effects of Pretargeting and FcRn Binding Abrogation on the Biodistribution of a One-Armed Antibody-Based T Cell Imaging Agent.
Danielle Mandikian, Lauren Sermeño, Rachana Ohri, Pragya Adhikari, Christopher W Davies, Jack D Sadowsky

Bioconjug Chem· August 2025

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On Demand Bioorthogonal Switching of an Antibody-Conjugated SPECT Probe to a Cytotoxic Payload: from Imaging to Therapy.
Pragya Adhikari, Guangmin Li, MaryAnn Go, Danielle Mandikian, Hanine Rafidi, Jack D Sadowsky

J Am Chem Soc· July 2024

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Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties.
Peter S Dragovich, Thomas H Pillow, Robert A Blake, Jack D Sadowsky, Emel Adaligil

J Med Chem· March 2021

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Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy.
Peter S Dragovich, Thomas H Pillow, Robert A Blake, Jack D Sadowsky, Emel Adaligil

J Med Chem· March 2021

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An Anti-CD22--CBI-Dimer Antibody-Drug Conjugate (ADC) for the Treatment of Non-Hodgkin Lymphoma That Provides a Longer Duration of Response than Auristatin-Based ADCs in Preclinical Models.
Shang-Fan Yu, Donna W Lee, Bing Zheng, Geoffrey Del Rosario, Douglas Leipold, Jack D Sadowsky

Mol Cancer Ther· February 2021

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Effect of Modulating FcRn Binding on Direct and Pretargeted Tumor Uptake of Full-length Antibodies.
Lidia Nazarova, Hanine Rafidi, Danielle Mandikian, Gregory Z Ferl, James T Koerber, Jack D Sadowsky

Mol Cancer Ther· April 2020

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Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα).
Peter S Dragovich, Pragya Adhikari, Robert A Blake, Nicole Blaquiere, Jinhua Chen, Jack D Sadowsky

Bioorg Med Chem Lett· February 2020

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Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity.
Thomas H Pillow, Pragya Adhikari, Robert A Blake, Jinhua Chen, Geoffrey Del Rosario, Jack D Sadowsky

ChemMedChem· January 2020

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Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody-Drug Conjugates.
Donglu Zhang, Aimee Fourie-O'Donohue, Peter S Dragovich, Thomas H Pillow, Jack D Sadowsky

Drug Metab Dispos· October 2019

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Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues.
Donglu Zhang, Peter S Dragovich, Shang-Fan Yu, Yong Ma, Thomas H Pillow, Jack D Sadowsky

Drug Metab Dispos· October 2019

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Intratumoral Payload Concentration Correlates with the Activity of Antibody-Drug Conjugates.
Donglu Zhang, Shang-Fan Yu, S Cyrus Khojasteh, Yong Ma, Thomas H Pillow, Jack D Sadowsky

Mol Cancer Ther· March 2018

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Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads.
Donglu Zhang, Hoa Le, Josefa Dela Cruz-Chuh, Sudheer Bobba, Jun Guo, Jack D Sadowsky

Bioconjug Chem· February 2018

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Development of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein- and Peptide-Payload Conjugates: Application to THIOMAB Antibody-Drug Conjugates.
Jack D Sadowsky, Thomas H Pillow, Jinhua Chen, Fang Fan, Changrong He

Bioconjug Chem· August 2017

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Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates.
Thomas H Pillow, Jack D Sadowsky, Donglu Zhang, Shang-Fan Yu, Geoffrey Del Rosario

Chem Sci· January 2017

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Linker Immolation Determines Cell Killing Activity of Disulfide-Linked Pyrrolobenzodiazepine Antibody-Drug Conjugates.
Donglu Zhang, Thomas H Pillow, Yong Ma, Josefa Dela Cruz-Chuh, Katherine R Kozak, Jack D Sadowsky

ACS Med Chem Lett· November 2016

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Chemical Structure and Concentration of Intratumor Catabolites Determine Efficacy of Antibody Drug Conjugates.
Donglu Zhang, Shang-Fan Yu, Yong Ma, Keyang Xu, Peter S Dragovich, Jack D Sadowsky

Drug Metab Dispos· September 2016

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A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1.
T Justin Rettenmaier, Jack D Sadowsky, Nathan D Thomsen, Steven C Chen, Allison K Doak

Proc Natl Acad Sci U S A· December 2014

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Ordering a dynamic protein via a small-molecule stabilizer.
Ningkun Wang, Chinmay Y Majmudar, William C Pomerantz, Jessica K Gagnon, Jack D Sadowsky

J Am Chem Soc· March 2013

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Turning a protein kinase on or off from a single allosteric site via disulfide trapping.
Jack D Sadowsky, Mark A Burlingame, Dennis W Wolan, Christopher L McClendon, Matthew P Jacobson

Proc Natl Acad Sci U S A· April 2011

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High-resolution structural characterization of a helical alpha/beta-peptide foldamer bound to the anti-apoptotic protein Bcl-xL.
Erinna F Lee, Jack D Sadowsky, Brian J Smith, Peter E Czabotar, Kimberly J Peterson-Kaufman

Angew Chem Int Ed Engl· September 2009

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Exploration of structure--activity relationships among foldamer ligands for a specific protein binding site via parallel and split-and-mix library synthesis.
Justin K Murray, Jack D Sadowsky, Mark Scalf, Lloyd M Smith, York Tomita

J Comb Chem· August 2008

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A fluorescence polarization assay for identifying ligands that bind to vascular endothelial growth factor.
Kimberly J Peterson, Jack D Sadowsky, Elizabeth A Scheef, Soumen Pal, Katerina D Kourentzi

Anal Biochem· July 2008

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Hydrophile scanning as a complement to alanine scanning for exploring and manipulating protein-protein recognition: application to the Bim BH3 domain.
Melissa D Boersma, Jack D Sadowsky, York A Tomita, Samuel H Gellman

Protein Sci· July 2008

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H/D exchange- and mass spectrometry-based strategy for the thermodynamic analysis of protein-ligand binding.
Liangjie Tang, Erin D Hopper, Yan Tong, Jack D Sadowsky, Kimberly J Peterson

Anal Chem· August 2007

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Exploration of backbone space in foldamers containing alpha- and beta-amino acid residues: developing protease-resistant oligomers that bind tightly to the BH3-recognition cleft of Bcl-xL.
Jack D Sadowsky, Justin K Murray, York Tomita, Samuel H Gellman

Chembiochem· May 2007

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