Publications by authors named "Jacob Corn"

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Genome editing with the HDR-enhancing DNA-PKcs inhibitor AZD7648 causes large-scale genomic alterations.
Grégoire Cullot, Eric J Aird, Moritz F Schlapansky, Charles D Yeh, Lilly van de Venn, Jacob E Corn

Nat Biotechnol· November 2025

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Treatment of GATA2 deficiency by allele-specific CRISPR-Cas9-directed gene correction in hematopoietic stem cells.
Thomas Wisbech Skov, Jonas Holst Wolff, Didde Haslund, Anne Louise Revenfeld, Lilly van de Venn, Jacob E Corn

Mol Ther· November 2025

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FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry.
Jennifer M Umhoefer, Maya M Arce, Sivakanthan Kasinathan, Sean Whalen, Rama Dajani, Jacob E Corn

Immunity· November 2025

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A split-site E3 ligase mechanism enables ZNFX1 to ubiquitinate and cluster single-stranded RNA into ubiquitin-coated nucleoprotein particles.
Daniel B Grabarczyk, Eric J Aird, Vanessa Reznikow, Paul C Kirchgatterer, Julian F Ehrmann, Jacob E Corn

Cell· October 2025

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WEE1 inhibitors synergise with mRNA translation defects via activation of the kinase GCN2.
Jordan C J Wilson, JiaYi Zhu, Vanesa Vinciauskaite, Eloise G Lloyd, Simon Lam, Jacob E Corn

Nat Commun· October 2025

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Cell-stereotyped DNA repair outcomes are widespread during genome editing.
Moritz F Schlapansky, Markus S Schröder, Antonio J Santinha, Tanja Rothgangl, Eleonora I Ioannidi, Jacob E Corn

bioRxiv· October 2025

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Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes.
Darshana Gupta, Constantinos Patinios, Harris V Bassett, Anuja Kibe, Scott P Collins, Jacob E Corn

Nat Biotechnol· September 2025

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Removal of TREX1 activity enhances CRISPR-Cas9-mediated homologous recombination.
Mehmet E Karasu, Eléonore Toufektchan, Yanyang Chen, Alessandra Albertelli, Grégoire Cullot, Jacob E Corn

Nat Biotechnol· July 2025

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Single-stranded HDR templates with truncated Cas12a-binding sequences improve knock-in efficiencies in primary human T cells.
Ana-Maria Nitulescu, Weijie Du, Viktor Glaser, Jonas Kath, Eric J Aird, Jacob E Corn

Mol Ther Nucleic Acids· June 2025

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Comprehensive interrogation of synthetic lethality in the DNA damage response.
John Fielden, Sebastian M Siegner, Danielle N Gallagher, Markus S Schröder, Maria Rosaria Dello Stritto, Jacob E Corn

Nature· April 2025

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C-terminal amides mark proteins for degradation via SCF-FBXO31.
Matthias F Muhar, Jakob Farnung, Martina Cernakova, Raphael Hofmann, Lukas T Henneberg, Jacob E Corn

Nature· February 2025

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Cis-Regulatory Element and Transcription Factor Circuitry Required for Cell-Type Specific Expression of FOXP3.
Jennifer M Umhoefer, Maya M Arce, Sean Whalen, Rama Dajani, Laine Goudy, Jacob E Corn

bioRxiv· January 2025

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Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy.
Jeremy G Baldwin, Christoph Heuser-Loy, Tanmoy Saha, Roland C Schelker, Dragana Slavkovic-Lukic, Jacob E Corn

Cell· November 2024

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CCAR1 promotes DNA repair via alternative splicing.
Mehmet E Karasu, Leonard Jahnke, Brian J Joseph, Yerkezhan Amerzhanova, Aleksei Mironov, Jacob E Corn

Mol Cell· July 2024

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Systematic decoding of cis gene regulation defines context-dependent control of the multi-gene costimulatory receptor locus in human T cells.
Cody T Mowery, Jacob W Freimer, Zeyu Chen, Salvador Casaní-Galdón, Jennifer M Umhoefer, Jacob E Corn

Nat Genet· June 2024

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Epitope-engineered human hematopoietic stem cells are shielded from CD123-targeted immunotherapy.
Romina Marone, Emmanuelle Landmann, Anna Devaux, Rosalba Lepore, Denis Seyres, Jacob E Corn, Tatjana I Cornu

J Exp Med· December 2023

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Engineering of the endogenous promoter increases HbA2.
Mandy Y Boontanrart, Elia Mächler, Simone Ponta, Jan C Nelis, Viviana G Preiano, Jacob E Corn

Elife· June 2023

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Semisynthetic LC3 Probes for Autophagy Pathways Reveal a Noncanonical LC3 Interacting Region Motif Crucial for the Enzymatic Activity of Human ATG3.
Jakob Farnung, Matthias Muhar, Jin Rui Liang, Kateryna A Tolmachova, Roger M Benoit, Jacob E Corn

ACS Cent Sci· May 2023

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Quantitative proteomic landscapes of primary and recurrent glioblastoma reveal a protumorigeneic role for FBXO2-dependent glioma-microenvironment interactions.
Marcel Buehler, Xiao Yi, Weigang Ge, Peter Blattmann, Elisabeth Rushing, Jacob E Corn

Neuro Oncol· February 2023

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A CRISPR view on autophagy.
Jin Rui Liang, Jacob E Corn

Trends Cell Biol· December 2022

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Adenine base editing efficiently restores the function of Fanconi anemia hematopoietic stem and progenitor cells.
Sebastian M Siegner, Laura Ugalde, Alexandra Clemens, Laura Garcia-Garcia, Juan A Bueren, Jacob E Corn

Nat Commun· November 2022

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Recursive Editing improves homology-directed repair through retargeting of undesired outcomes.
Lukas Möller, Eric J Aird, Markus S Schröder, Lena Kobel, Lucas Kissling, Jacob E Corn

Nat Commun· August 2022

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High-level correction of the sickle mutation is amplified during erythroid differentiation.
Wendy Magis, Mark A DeWitt, Stacia K Wyman, Jonathan T Vu, Seok-Jin Heo, Jacob E Corn

iScience· June 2022

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Facile Preparation of UFMylation Activity-Based Probes by Chemoselective Installation of Electrophiles at the C-Terminus of Recombinant UFM1.
Kateryna A Tolmachova, Jakob Farnung, Jin Rui Liang, Jacob E Corn, Jeffrey W Bode

ACS Cent Sci· June 2022

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Imaging Unique DNA Sequences in Individual Cells Using a CRISPR-Cas9-Based, Split Luciferase Biosensor.
Nicholas G Heath, Henriette O'Geen, Nicole B Halmai, Jacob E Corn, David J Segal

Front Genome Ed· March 2022

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