Publications by authors named "Jacob W Freimer"

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FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry.
Jennifer M Umhoefer, Maya M Arce, Sivakanthan Kasinathan, Sean Whalen, Rama Dajani, Jacob W Freimer

Immunity· November 2025

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Cis-Regulatory Element and Transcription Factor Circuitry Required for Cell-Type Specific Expression of FOXP3.
Jennifer M Umhoefer, Maya M Arce, Sean Whalen, Rama Dajani, Laine Goudy, Jacob W Freimer

bioRxiv· January 2025

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Central control of dynamic gene circuits governs T cell rest and activation.
Maya M Arce, Jennifer M Umhoefer, Nadia Arang, Sivakanthan Kasinathan, Jacob W Freimer

Nature· January 2025

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Gene regulatory network inference from CRISPR perturbations in primary CD4 T cells elucidates the genomic basis of immune disease.
Joshua S Weinstock, Maya M Arce, Jacob W Freimer, Mineto Ota, Alexander Marson

Cell Genom· November 2024

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Systematic decoding of cis gene regulation defines context-dependent control of the multi-gene costimulatory receptor locus in human T cells.
Cody T Mowery, Jacob W Freimer, Zeyu Chen, Salvador Casaní-Galdón, Jennifer M Umhoefer

Nat Genet· June 2024

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A model for accurate quantification of CRISPR effects in pooled FACS screens.
Harold Pimentel, Jacob W Freimer, Maya M Arce, Christian M Garrido, Alexander Marson

bioRxiv· June 2024

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Gene regulatory network inference from CRISPR perturbations in primary CD4+ T cells elucidates the genomic basis of immune disease.
Joshua S Weinstock, Maya M Arce, Jacob W Freimer, Mineto Ota, Alexander Marson

bioRxiv· October 2023

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CRISPR screens decode cancer cell pathways that trigger γδ T cell detection.
Murad R Mamedov, Shane Vedova, Jacob W Freimer, Avinash Das Sahu, Amrita Ramesh

Nature· September 2023

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Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture of immune networks.
Jacob W Freimer, Oren Shaked, Sahin Naqvi, Nasa Sinnott-Armstrong, Arwa Kathiria

Nat Genet· August 2022

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Cell-cell adhesions in embryonic stem cells regulate the stability and transcriptional activity of β-catenin.
Sinjini Bhattacharyya, Ridim D Mote, Jacob W Freimer, Mahak Tiwari, Surya Bansi Singh

FEBS Lett· July 2022

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G1/S restriction point coordinates phasic gene expression and cell differentiation.
Brian DeVeale, Leqian Liu, Ryan Boileau, Jennifer Swindlehurst-Chan, Bryan Marsh, Jacob W Freimer

Nat Commun· June 2022

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CRISPR activation and interference screens decode stimulation responses in primary human T cells.
Ralf Schmidt, Zachary Steinhart, Madeline Layeghi, Jacob W Freimer, Raymund Bueno

Science· February 2022

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High-throughput, Efficient, and Unbiased Capture of Small RNAs from Low-input Samples for Sequencing.
Cassandra D Belair, Tianyi Hu, Brandon Chu, Jacob W Freimer, Matthew R Cooperberg

Sci Rep· February 2019

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GRHL2-Dependent Enhancer Switching Maintains a Pluripotent Stem Cell Transcriptional Subnetwork after Exit from Naive Pluripotency.
Amy F Chen, Arthur J Liu, Raga Krishnakumar, Jacob W Freimer, Brian DeVeale

Cell Stem Cell· August 2018

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Decoupling the impact of microRNAs on translational repression versus RNA degradation in embryonic stem cells.
Jacob W Freimer, T J Hu, Robert Blelloch

Elife· July 2018

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Expression of Alternative Ago2 Isoform Associated with Loss of microRNA-Driven Translational Repression in Mouse Oocytes.
Jacob W Freimer, Raga Krishnakumar, Matthew S Cook, Robert Blelloch

Curr Biol· January 2018

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