Publications by authors named "Jacob D McDonald"

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Preclinical assessment of pharmacokinetics and anticonvulsant activity of CBDTech, a novel orally administered cannabidiol (CBD) formulation for seizure and epilepsy.
Jacob D McDonald, Feng Zhou, Justyna Kulpa, Philip J Kuehl

J Cannabis Res· September 2025

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Effect of TRPV4 Antagonist GSK2798745 on Chlorine Gas-Induced Acute Lung Injury in a Swine Model.
Meghan S Vermillion, Nathan Saari, Mathieu Bray, Andrew M Nelson, Robert L Bullard, Jacob D McDonald

Int J Mol Sci· April 2024

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Inhalation delivery of nucleic acid gene therapies in preclinical drug development.
Conor A Ruzycki, Derek Montoya, Hammad Irshad, Jason Cox, Yue Zhou, Jacob D McDonald

Expert Opin Drug Deliv· November 2023

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Pharmacokinetics of Oral Minor Cannabinoids in Blood and Brain.
Catherine F Moore, Elise M Weerts, Justyna Kulpa, Daniela Schwotzer, Wendy Dye, Jacob D McDonald

Cannabis Cannabinoid Res· September 2023

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Evaluating Potential Anxiolytic Effects of Minor Cannabinoids and Terpenes After Acute and Chronic Oral Administration in Rats.
Bryan W Jenkins, Catherine F Moore, Dan Covey, Jacob D McDonald, Timothy W Lefever

Cannabis Cannabinoid Res· September 2023

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Prenatal airborne polycyclic aromatic hydrocarbon exposure, altered regulation of peroxisome proliferator-activated receptor gamma (Ppar)γ, and links with mammary cancer.
Lydia Lichtiger, Jacqueline Jezioro, Janelle Rivera, Jacob D McDonald, Mary Beth Terry

Environ Res· August 2023

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HS-GC-FID method for quantification of HFA-152a in cell culture media, and plasma from a range of species and regulatory compliant validations.
Philip J Kuehl, Stuart Corr, Jabari Farrar, Jacob D McDonald, Tim Wermer

J Pharmacol Toxicol Methods· July 2023

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Characterization of aerosols from hemp-derived pre-roll joints.
Hammad Irshad, Justyna Kulpa, Philip J Kuehl, Tim Lefever, Jacob D McDonald

Inhal Toxicol· May 2023

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Composition of aerosols from thermal degradation of flavors used in ENDS and tobacco products.
Philip J Kuehl, Jacob D McDonald, Derek T Weber, Andrey Khlystov, Matthew A Nystoriak

Inhal Toxicol· November 2022

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Traffic-generated air pollution - Exposure mediated expression of factors associated with demyelination in a female apolipoprotein E mouse model.
Anna Adivi, JoAnn Lucero, Nicholas Simpson, Jacob D McDonald, Amie K Lund

Neurotoxicol Teratol· April 2022

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Disposition and metabolism of ethylene glycol 2-ethylhexyl ether in Sprague Dawley rats, B6C3F1/N mice, and in rat hepatocytes.
AtLee T D Watson, Benjamin C Moeller, Melanie Doyle-Eisele, Edwin Garner, Chad R Blystone, Jacob D McDonald

Xenobiotica· June 2021

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Prenatal polycyclic aromatic hydrocarbons, altered ERα pathway-related methylation and expression, and mammary epithelial cell proliferation in offspring and grandoffspring adult mice.
Debashish Sahay, Susan E Lloyd, Janelle A Rivera, Jacqueline Jezioro, Jacob D McDonald

Environ Res· May 2021

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Exposure to traffic-generated air pollution promotes alterations in the integrity of the brain microvasculature and inflammation in female ApoE mice.
Anna Adivi, JoAnn Lucero, Nicholas Simpson, Jacob D McDonald, Amie K Lund

Toxicol Lett· March 2021

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Disposition and metabolism of 2,2'-dimorpholinodiethyl ether in sprague dawley rats and B6C3F1/N mice after oral, intravenous administration, and dermal application.
Suramya Waidyanatha, Jacob D McDonald, J Michael Sanders, Melanie Doyle-Eisele, Benjamin C Moeller

Xenobiotica· November 2020

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Disposition and metabolism of 2',2'"-Dithiobisbenzanilide in rodents following intravenous and oral administration and dermal application.
C Edwin Garner, Christopher J Wegerski, Melanie Doyle-Eisele, Jacob D McDonald, J Michael Sanders

Toxicol Rep· July 2020

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Vehicular Particulate Matter (PM) Characteristics Impact Vascular Outcomes Following Inhalation.
Katherine E Zychowski, Christina R Steadman Tyler, Bethany Sanchez, Molly Harmon, June Liu, Jacob D McDonald

Cardiovasc Toxicol· June 2020

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Metabolism and disposition of 2-hydroxy-4-methoxybenzophenone, a sunscreen ingredient, in Harlan Sprague Dawley rats and B6C3F1/N mice; a species and route comparison.
Esra Mutlu, C Edwin Garner, Christopher J Wegerski, Jacob D McDonald, Barry S McIntyre

Xenobiotica· June 2020

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Effects of inhaled air pollution on markers of integrity, inflammation, and microbiota profiles of the intestines in Apolipoprotein E knockout mice.
Megan N Fitch, Danielle Phillippi, Yan Zhang, JoAnn Lucero, Ravi S Pandey, Jacob D McDonald

Environ Res· February 2020

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Mixed Vehicle Emissions Induces Angiotensin II and Cerebral Microvascular Angiotensin Receptor Expression in C57Bl/6 Mice and Promotes Alterations in Integrity in a Blood-Brain Barrier Coculture Model.
Usa Suwannasual, JoAnn Lucero, Griffith Davis, Jacob D McDonald, Amie K Lund

Toxicol Sci· August 2019

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Pulmonary and Regional Deposition of Nebulized and Dry Powder Aerosols in Ferrets.
Philip J Kuehl, Ramesh Chand, Jacob D McDonald, David L Hava, Wesley H DeHaan

AAPS PharmSciTech· July 2019

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The pharmacokinetics of ketamine following intramuscular injection to F344 rats.
Benjamin Moeller, Brenna Espelien, Waylon Weber, Philip Kuehl, Melanie Doyle-Eisele, Jacob D McDonald

Drug Test Anal· January 2019

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Addition of ketamine to standard-of-care countermeasures for acute organophosphate poisoning improves neurobiological outcomes.
Jeffrey David Lewine, Waylon Weber, Andrew Gigliotti, Jacob D McDonald, Melanie Doyle-Eisele

Neurotoxicology· December 2018

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The effects of subacute inhaled multi-walled carbon nanotube exposure on signaling pathways associated with cholesterol transport and inflammatory markers in the vasculature of wild-type mice.
Griffith Davis, JoAnn Lucero, Caitlin Fellers, Jacob D McDonald, Amie K Lund

Toxicol Lett· October 2018

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Exposure to traffic-generated air pollutants mediates alterations in brain microvascular integrity in wildtype mice on a high-fat diet.
Usa Suwannasual, JoAnn Lucero, Jacob D McDonald, Amie K Lund

Environ Res· January 2018

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Disposition of β-N-methylamino-l-alanine (L-BMAA), a neurotoxin, in rodents following a single or repeated oral exposure.
Suramya Waidyanatha, Kristen Ryan, J Michael Sanders, Jacob D McDonald, Christopher J Wegerski

Toxicol Appl Pharmacol· January 2018

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