Publications by authors named "Jacob LaStant"

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Selective Btk inhibition by PRN1008/PRN473 blocks human CLEC-2, and PRN473 reduces venous thrombosis formation in mice.
Christopher W Smith, Joana Campos, Helena C Brown, Natalie J Jooss, Vanesa-Sindi Ivanova, Jacob LaStant

Blood Adv· November 2024

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Discovery of Reversible Covalent Bruton's Tyrosine Kinase Inhibitors PRN473 and PRN1008 (Rilzabrutinib).
Timothy D Owens, Ken A Brameld, Erik J Verner, Tony Ton, Xiaoyan Li, Jacob LaStant

J Med Chem· April 2022

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Preclinical Efficacy and Anti-Inflammatory Mechanisms of Action of the Bruton Tyrosine Kinase Inhibitor Rilzabrutinib for Immune-Mediated Disease.
Claire L Langrish, J Michael Bradshaw, Michelle R Francesco, Timothy D Owens, Yan Xing, Jacob LaStant

J Immunol· April 2021

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Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity.
Michael Basler, Michelle M Lindstrom, Jacob J LaStant, J Michael Bradshaw, Timothy D Owens

EMBO Rep· December 2018

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The Irreversible Covalent Fibroblast Growth Factor Receptor Inhibitor PRN1371 Exhibits Sustained Inhibition of FGFR after Drug Clearance.
Eleni Venetsanakos, Ken A Brameld, Vernon T Phan, Erik Verner, Timothy D Owens, Jacob LaStant

Mol Cancer Ther· December 2017

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Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors.
Ken A Brameld, Timothy D Owens, Erik Verner, Eleni Venetsanakos, J Michael Bradshaw, Jacob LaStant

J Med Chem· August 2017

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Suppression of glomerulonephritis in lupus-prone NZB × NZW mice by RN486, a selective inhibitor of Bruton's tyrosine kinase.
Paola Mina-Osorio, Jacob LaStant, Natalie Keirstead, Toni Whittard, Julia Ayala

Arthritis Rheum· September 2013

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