Publications by authors named "Jacob Mahoney"

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1-Hydroxy-1,8-napthyridinone (DHN) Analogs Potently Inhibit Monkeypox Virus Resolvase (Mpr).
Samuel Offei, Jacob P Mahoney, Ziyue Wang, Anil Pant, Won Hee Ryu

J Med Chem· January 2026

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Discovery and Characterization of a Hydroxypyridone-3-carboxamide Analog as an Antiviral Lead against Orthopoxviruses.
Anil Pant, Ajit Jagtap, Jiashu Xie, Djamal Brahim Belhaouari, Wei Xie, Jacob P Mahoney

bioRxiv· December 2025

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Discovery of Small-Molecule Orthopoxvirus Resolvase Inhibitors with Antiviral Activity.
Jacob P Mahoney, Samuel Offei, Anil Pant, Ziyue Wang, Benjamin Weiner

J Med Chem· July 2025

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The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling.
Elise S Bruguera, Jacob P Mahoney, William I Weis

Elife· January 2025

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The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling.
Elise S Bruguera, Jacob P Mahoney, William I Weis

bioRxiv· November 2024

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PI(4,5)P-stimulated positive feedback drives the recruitment of Dishevelled to Frizzled in Wnt-β-catenin signaling.
Jacob P Mahoney, Elise S Bruguera, Mansi Vasishtha, Lauren B Killingsworth, Saw Kyaw

Sci Signal· August 2022

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Reconstitution of purified membrane protein dimers in lipid nanodiscs with defined stoichiometry and orientation using a split GFP tether.
Elise S Bruguera, Jacob P Mahoney, William I Weis

J Biol Chem· April 2022

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Structure of an endosomal signaling GPCR-G protein-β-arrestin megacomplex.
Anthony H Nguyen, Alex R B Thomsen, Thomas J Cahill, Rick Huang, Li-Yin Huang, Jacob P Mahoney

Nat Struct Mol Biol· December 2019

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Publisher Correction: Structural insights into binding specificity, efficacy and bias of a βAR partial agonist.
Matthieu Masureel, Yaozhong Zou, Louis-Philippe Picard, Emma van der Westhuizen, Jacob P Mahoney

Nat Chem Biol· February 2019

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Structural insights into binding specificity, efficacy and bias of a βAR partial agonist.
Matthieu Masureel, Yaozhong Zou, Louis-Philippe Picard, Emma van der Westhuizen, Jacob P Mahoney

Nat Chem Biol· November 2018

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Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor.
Kathryn E Livingston, Jacob P Mahoney, Aashish Manglik, Roger K Sunahara, John R Traynor

Elife· June 2018

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Mechanistic insights into GPCR-G protein interactions.
Jacob P Mahoney, Roger K Sunahara

Curr Opin Struct Biol· December 2016

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GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling.
Alex R B Thomsen, Bianca Plouffe, Thomas J Cahill, Arun K Shukla, Jeffrey T Tarrasch, Jacob P Mahoney

Cell· August 2016

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Allosteric coupling from G protein to the agonist-binding pocket in GPCRs.
Brian T DeVree, Jacob P Mahoney, Gisselle A Vélez-Ruiz, Soren G F Rasmussen, Adam J Kuszak

Nature· July 2016

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Electron Microscopic Visualization of Protein Assemblies on Flattened DNA Origami.
Leena Mallik, Soma Dhakal, Joseph Nichols, Jacob Mahoney, Anne M Dosey

ACS Nano· July 2015

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Conformational biosensors reveal GPCR signalling from endosomes.
Roshanak Irannejad, Jin C Tomshine, Jon R Tomshine, Michael Chevalier, Jacob P Mahoney

Nature· March 2013

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