Publications by authors named "Jacob Mitchell"

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Advancing biological understanding of cellular senescence with computational multiomics.
Sheng Li, Paula A Agudelo Garcia, Constantin Aliferis, Michael J Becich, Jazmin Calyeca, Jacob T Mitchell

Nat Genet· October 2025

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Spatial profiling of human pancreatic ductal adenocarcinoma reveals molecular alterations associated with venous invasion.
Alexander T F Bell, Peter Chianchiano, Katsuya Hirose, Daniel Salas-Escabillas, Doreen M Zucha, Jacob T Mitchell

Sci Transl Med· September 2025

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Spatial proteomics and transcriptomics reveal early immune cell organization in pancreatic intraepithelial neoplasia.
Melissa R Lyman, Jacob T Mitchell, Sidharth Raghavan, Luciane T Kagohara, Amanda L Huff

JCI Insight· August 2025

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Human interpretable grammar encodes multicellular systems biology models to democratize virtual cell laboratories.
Jeanette A I Johnson, Daniel R Bergman, Heber L Rocha, David L Zhou, Eric Cramer, Jacob T Mitchell

Cell· August 2025

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Novel stereo DIC characterisation of microneedle and hypodermic needle insertion.
Megan McNamee, Thomas Pritchard, Jacob Mitchell, Chris Bolton, Kerry Roberts

Front Bioeng Biotechnol· June 2025

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Differential cell signaling testing for cell-cell communication inference from single-cell data by dominoSignal.
Jacob T Mitchell, Orian Stapleton, Kavita Krishnan, Sushma Nagaraj, Dmitrijs Lvovs

bioRxiv· May 2025

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COVID-19 knowledge, attitudes, and behaviors of STEM vs. non-STEM college students in Central Appalachia in 2021, a student-led project.
Ahauve Orusa, Amy Wahlquist, Delaney Lawson, Ossama Riaz, Jacob Mitchell

J Am Coll Health· April 2025

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Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially control regulatory T cell phenotype and function via CXCL9 and CCL22.
Saumya Y Maru, Meredith Wetzel, Jacob T Mitchell, Nicole E Gross, Lalitya Andaloori

bioRxiv· April 2025

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Human Pancreatic Cancer Single-Cell Atlas Reveals Association of CXCL10+ Fibroblasts and Basal Subtype Tumor Cells.
Ian M Loveless, Samantha B Kemp, Kailee M Hartway, Jacob T Mitchell, Yuesong Wu

Clin Cancer Res· February 2025

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CD137 agonism enhances anti-PD1 induced activation of expanded CD8 T cell clones in a neoadjuvant pancreatic cancer clinical trial.
Janelle M Montagne, Jacob T Mitchell, Joseph A Tandurella, Eric S Christenson, Ludmila V Danilova, Sarah Mitchell

iScience· January 2025

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Cancer associated fibroblasts drive epithelial to mesenchymal transition and classical to basal change in pancreatic ductal adenocarcinoma cells with loss of IL-8 expression.
Samantha Guinn, Brayan Perez, Joseph A Tandurella, Mili Ramani, Jae W Lee, Jacob Mitchell

bioRxiv· January 2025

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Dobutamine-Induced Myoclonus in a Patient With Acute Decompensated Heart Failure and Acute Kidney Injury: A Case Report and Literature Review.
Saeed K Alzghari, Markus D Moore, Jacob C Mitchell

Cureus· January 2025

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Intrinsic GATA4 expression sensitizes the aortic root to dilation in a Loeys-Dietz syndrome mouse model.
Emily E Bramel, Wendy A Espinoza Camejo, Tyler J Creamer, Leda Restrepo, Muzna Saqib, Jacob T Mitchell

Nat Cardiovasc Res· December 2024

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Phosphodiesterase-5 inhibition collaborates with vaccine-based immunotherapy to reprogram myeloid cells in pancreatic ductal adenocarcinoma.
Nicole E Gross, Zhehao Zhang, Jacob T Mitchell, Soren Charmsaz, Alexei G Hernandez

JCI Insight· August 2024

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PanIN and CAF transitions in pancreatic carcinogenesis revealed with spatial data integration.
Alexander T F Bell, Jacob T Mitchell, Ashley L Kiemen, Melissa Lyman, Kohei Fujikura

Cell Syst· August 2024

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Intrinsic expression sensitizes the aortic root to dilation in a Loeys-Dietz syndrome mouse model.
Emily E Bramel, Wendy A Espinoza Camejo, Tyler J Creamer, Leda Restrepo, Muzna Saqib, Jacob T Mitchell

Res Sq· June 2024

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Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial-Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Adenocarcinoma.
Samantha Guinn, Benedict Kinny-Köster, Joseph A Tandurella, Jacob T Mitchell, Dimitrios N Sidiropoulos

Cancer Res· May 2024

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Inferring cellular and molecular processes in single-cell data with non-negative matrix factorization using Python, R and GenePattern Notebook implementations of CoGAPS.
Jeanette A I Johnson, Ashley P Tsang, Jacob T Mitchell, David L Zhou, Julia Bowden

Nat Protoc· December 2023

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CD4 T cell-activating neoantigens enhance personalized cancer vaccine efficacy.
Amanda L Huff, Gabriella Longway, Jacob T Mitchell, Lalitya Andaloori, Emily Davis-Marcisak

JCI Insight· December 2023

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Digitize your Biology! Modeling multicellular systems through interpretable cell behavior.
Jeanette A I Johnson, Genevieve L Stein-O'Brien, Max Booth, Randy Heiland, Furkan Kurtoglu, Jacob Mitchell

bioRxiv· November 2023

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MR Imaging of Germ Cell and Sex Cord Stromal Tumors.
Jacob R Mitchell, Evan S Siegelman, Karthik M Sundaram

Magn Reson Imaging Clin N Am· February 2023

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Multi-omic analyses of changes in the tumor microenvironment of pancreatic adenocarcinoma following neoadjuvant treatment with anti-PD-1 therapy.
Keyu Li, Joseph A Tandurella, Jessica Gai, Qingfeng Zhu, Su Jin Lim, Jacob T Mitchell

Cancer Cell· November 2022

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Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24.
Sophia Davidson, Chien-Hsiung Yu, Annemarie Steiner, Frédéric Ebstein, Paul J Baker, Jacob Mitchell

Sci Immunol· February 2022

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Relapsing polychondritis: state-of-the-art review with three case presentations.
Bogna Grygiel-Górniak, Hamza Tariq, Jacob Mitchell, Azad Mohammed, Włodzimierz Samborski

Postgrad Med· November 2021

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Application of Molecular Vapour Deposited AlO for Graphene-Based Biosensor Passivation and Improvements in Graphene Device Homogeneity.
Muhammad Munem Ali, Jacob John Mitchell, Gregory Burwell, Klaudia Rejnhard, Cerys Anne Jenkins

Nanomaterials (Basel)· August 2021

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